ID   PER_DRORO               Reviewed;          86 AA.
AC   Q03296;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-1993, sequence version 1.
DT   25-MAY-2022, entry version 53.
DE   RecName: Full=Period circadian protein;
DE   Flags: Fragment;
GN   Name=per;
OS   Drosophila robusta (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC   Drosophilidae; Drosophila.
OX   NCBI_TaxID=7257;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8450754; DOI=10.1093/oxfordjournals.molbev.a039993;
RA   Peixoto A.A., Campesan S., Costa R.H., Kyriacou C.P.;
RT   "Molecular evolution of a repetitive region within the per gene of
RT   Drosophila.";
RL   Mol. Biol. Evol. 10:127-139(1993).
CC   -!- FUNCTION: Essential for biological clock functions. Determines the
CC       period length of circadian and ultradian rhythms; an increase in PER
CC       dosage leads to shortened circadian rhythms and a decrease leads to
CC       lengthened circadian rhythms. Essential for the circadian rhythmicity
CC       of locomotor activity, eclosion behavior, and for the rhythmic
CC       component of the male courtship song that originates in the thoracic
CC       nervous system. The biological cycle depends on the rhythmic formation
CC       and nuclear localization of the TIM-PER complex. Light induces the
CC       degradation of TIM, which promotes elimination of PER. Nuclear activity
CC       of the heterodimer coordinatively regulates PER and TIM transcription
CC       through a negative feedback loop. Behaves as a negative element in
CC       circadian transcriptional loop. Does not appear to bind DNA, suggesting
CC       indirect transcriptional inhibition (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Forms a heterodimer with timeless (TIM); the complex then
CC       translocates into the nucleus. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm, perinuclear
CC       region {ECO:0000250}. Note=Nuclear at specific periods of the day.
CC       First accumulates in the perinuclear region about one hour before
CC       translocation into the nucleus. Interaction with Tim is required for
CC       nuclear localization (By similarity). {ECO:0000250}.
CC   -!- DOMAIN: The run of Gly-Thr is implicated in the maintenance of
CC       circadian period at different temperatures. Deletion of the repeat
CC       leads to a shortening of the courtship song cycle period, and thus
CC       could be important for determining features of species-specific mating
CC       behavior (By similarity). {ECO:0000250}.
CC   -!- PTM: Phosphorylated with a circadian rhythmicity, probably by the
CC       double-time protein (dbt). Phosphorylation could be implicated in the
CC       stability of per monomer and in the formation of heterodimer per-tim
CC       (By similarity). {ECO:0000250}.
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DR   EMBL; L06340; AAA28763.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q03296; -.
DR   FlyBase; FBgn0012755; Drob\per.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0048511; P:rhythmic process; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Biological rhythms; Cytoplasm; Nucleus; Phosphoprotein; Repeat.
FT   CHAIN           <1..>86
FT                   /note="Period circadian protein"
FT                   /id="PRO_0000162605"
FT   REPEAT          30..31
FT                   /note="1"
FT   REPEAT          32..33
FT                   /note="2"
FT   REPEAT          34..35
FT                   /note="3"
FT   REPEAT          36..37
FT                   /note="4"
FT   REPEAT          38..39
FT                   /note="5"
FT   REPEAT          40..41
FT                   /note="6"
FT   REPEAT          42..43
FT                   /note="7; approximate"
FT   REPEAT          44..45
FT                   /note="8"
FT   REPEAT          46..47
FT                   /note="9"
FT   REPEAT          48..49
FT                   /note="10; approximate"
FT   REPEAT          50..51
FT                   /note="11"
FT   REPEAT          52..53
FT                   /note="12"
FT   REGION          1..86
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          30..53
FT                   /note="12 X 2 AA approximate tandem repeats of G-T"
FT   NON_TER         1
FT   NON_TER         86
SQ   SEQUENCE   86 AA;  7746 MW;  C374AD7D7A06F0CE CRC64;
     EGSGGSGSSG NFTTGSNIRM SSVTNTSNAG TGTGTGTGTG TATGTGTATG TGTSAGGTSA
     GGNASGNSGN PPPAFAITLT ETLLNK