ID   PDZ11_PIG               Reviewed;         140 AA.
AC   Q6QA76;
DT   16-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 94.
DE   RecName: Full=PDZ domain-containing protein 11;
GN   Name=PDZD11; Synonyms=PDZK11;
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Lee H.Y., Cui X.S., Jeong Y.J., Shin M.L., Hwang K.C., Kim N.H.;
RT   "Identification of differentially expressed genes in porcine embryos.";
RL   Submitted (FEB-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Mediates docking of ADAM10 to zonula adherens by interacting
CC       with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10-
CC       binding protein TSPAN33. {ECO:0000250|UniProtKB:Q5EBL8}.
CC   -!- SUBUNIT: Interacts with ATP2B1, ATP2B2, ATP2B3, ATP2B4 and ATP7A (By
CC       similarity). Interacts with PLEKHA7 (via WW domains) at zonula
CC       adherens; this interaction is essential for the interaction between
CC       PLEKHA7 and the ADAM10-binding protein TSPAN33 (By similarity).
CC       Interacts with SLC5A6 (By similarity). {ECO:0000250|UniProtKB:Q5EBL8}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q5EBL8}. Cell
CC       junction, adherens junction {ECO:0000250|UniProtKB:Q9CZG9}. Cell
CC       membrane {ECO:0000250|UniProtKB:Q9CZG9}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AY550924; AAS59062.1; -; mRNA.
DR   RefSeq; NP_001001630.1; NM_001001630.1.
DR   RefSeq; XP_013846370.1; XM_013990916.1.
DR   AlphaFoldDB; Q6QA76; -.
DR   SMR; Q6QA76; -.
DR   STRING; 9823.ENSSSCP00000013173; -.
DR   PaxDb; Q6QA76; -.
DR   PeptideAtlas; Q6QA76; -.
DR   Ensembl; ENSSSCT00000013535; ENSSSCP00000013173; ENSSSCG00000012378.
DR   Ensembl; ENSSSCT00015050930; ENSSSCP00015020329; ENSSSCG00015038016.
DR   Ensembl; ENSSSCT00025091274; ENSSSCP00025040034; ENSSSCG00025066463.
DR   Ensembl; ENSSSCT00030053109; ENSSSCP00030024234; ENSSSCG00030038120.
DR   Ensembl; ENSSSCT00035075080; ENSSSCP00035030518; ENSSSCG00035056247.
DR   Ensembl; ENSSSCT00040023831; ENSSSCP00040010101; ENSSSCG00040017645.
DR   Ensembl; ENSSSCT00045029181; ENSSSCP00045020215; ENSSSCG00045017147.
DR   Ensembl; ENSSSCT00050057215; ENSSSCP00050024423; ENSSSCG00050042119.
DR   Ensembl; ENSSSCT00055035867; ENSSSCP00055028488; ENSSSCG00055018326.
DR   Ensembl; ENSSSCT00060012592; ENSSSCP00060004761; ENSSSCG00060009727.
DR   Ensembl; ENSSSCT00065082626; ENSSSCP00065035992; ENSSSCG00065060313.
DR   Ensembl; ENSSSCT00070054957; ENSSSCP00070046618; ENSSSCG00070027385.
DR   Ensembl; ENSSSCT00070054965; ENSSSCP00070046625; ENSSSCG00070027385.
DR   GeneID; 414386; -.
DR   KEGG; ssc:414386; -.
DR   CTD; 51248; -.
DR   VGNC; VGNC:91294; PDZD11.
DR   eggNOG; KOG3528; Eukaryota.
DR   GeneTree; ENSGT00940000153222; -.
DR   InParanoid; Q6QA76; -.
DR   OMA; ERIYHSD; -.
DR   OrthoDB; 1530562at2759; -.
DR   TreeFam; TF318964; -.
DR   Reactome; R-SSC-196780; Biotin transport and metabolism.
DR   Reactome; R-SSC-199220; Vitamin B5 (pantothenate) metabolism.
DR   Reactome; R-SSC-425397; Transport of vitamins, nucleosides, and related molecules.
DR   Reactome; R-SSC-6803544; Ion influx/efflux at host-pathogen interface.
DR   Reactome; R-SSC-936837; Ion transport by P-type ATPases.
DR   Proteomes; UP000008227; Chromosome X.
DR   Proteomes; UP000314985; Unassembled WGS sequence.
DR   Bgee; ENSSSCG00000012378; Expressed in adult mammalian kidney and 45 other tissues.
DR   ExpressionAtlas; Q6QA76; baseline and differential.
DR   Genevisible; Q6QA76; SS.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0016323; C:basolateral plasma membrane; ISS:UniProtKB.
DR   GO; GO:0005911; C:cell-cell junction; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; ISS:UniProtKB.
DR   GO; GO:0046930; C:pore complex; IEA:Ensembl.
DR   GO; GO:0098793; C:presynapse; IEA:GOC.
DR   GO; GO:0045202; C:synapse; IBA:GO_Central.
DR   GO; GO:0008022; F:protein C-terminus binding; ISS:UniProtKB.
DR   GO; GO:0045199; P:maintenance of epithelial cell apical/basal polarity; IBA:GO_Central.
DR   GO; GO:0007269; P:neurotransmitter secretion; IBA:GO_Central.
DR   GO; GO:0046931; P:pore complex assembly; IEA:Ensembl.
DR   GO; GO:1903361; P:protein localization to basolateral plasma membrane; IBA:GO_Central.
DR   Gene3D; 2.30.42.10; -; 1.
DR   InterPro; IPR001478; PDZ.
DR   InterPro; IPR036034; PDZ_sf.
DR   Pfam; PF00595; PDZ; 1.
DR   SMART; SM00228; PDZ; 1.
DR   SUPFAM; SSF50156; SSF50156; 1.
DR   PROSITE; PS50106; PDZ; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Cell membrane; Cytoplasm; Membrane; Reference proteome.
FT   CHAIN           1..140
FT                   /note="PDZ domain-containing protein 11"
FT                   /id="PRO_0000058275"
FT   DOMAIN          47..129
FT                   /note="PDZ"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00143"
SQ   SEQUENCE   140 AA;  16155 MW;  58299B0DAB01EF66 CRC64;
     MDSRIPYDDY PVVFLPAYEN PPAWIPPHER VYHPDYNNEL TQFLPRIVTL KKPPGAQLGF
     NIRGGKASQL GIFISKVIPD SDAHRAGLQE GDQVLAVNDV DFQDIEHSKA VEILKTAREI
     SMRVRFFPYN YHRQKERTVH