PDYN_PIG
ID PDYN_PIG Reviewed; 256 AA.
AC P01214;
DT 21-JUL-1986, integrated into UniProtKB/Swiss-Prot.
DT 21-JUL-1986, sequence version 1.
DT 25-MAY-2022, entry version 100.
DE RecName: Full=Proenkephalin-B;
DE AltName: Full=Beta-neoendorphin-dynorphin;
DE AltName: Full=Preprodynorphin;
DE Contains:
DE RecName: Full=Alpha-neoendorphin;
DE Contains:
DE RecName: Full=Beta-neoendorphin;
DE Contains:
DE RecName: Full=Big dynorphin;
DE Short=Big Dyn;
DE Contains:
DE RecName: Full=Dynorphin A(1-17);
DE Short=Dyn-A17;
DE Short=Dynorphin A;
DE Contains:
DE RecName: Full=Dynorphin A(1-13);
DE Contains:
DE RecName: Full=Dynorphin A(1-8);
DE Contains:
DE RecName: Full=Leu-enkephalin;
DE Contains:
DE RecName: Full=Rimorphin;
DE AltName: Full=Dynorphin B;
DE Short=Dyn-B;
DE AltName: Full=Dynorphin B(1-13);
DE Contains:
DE RecName: Full=Leumorphin;
DE AltName: Full=Dynorphin B-29;
DE Flags: Precursor;
GN Name=PDYN;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Hypothalamus;
RX PubMed=6123953; DOI=10.1038/298245a0;
RA Kakidani H., Furutani Y., Takahashi H., Noda M., Morimoto Y., Hirose T.,
RA Asai M., Inayama S., Nakanishi S., Numa S.;
RT "Cloning and sequence analysis of cDNA for porcine beta-neo-
RT endorphin/dynorphin precursor.";
RL Nature 298:245-249(1982).
RN [2]
RP PROTEIN SEQUENCE OF 209-221, IDENTIFICATION, AND CHARACTERIZATION OF
RP DYNORPHIN A(1-13).
RX PubMed=230519; DOI=10.1073/pnas.76.12.6666;
RA Goldstein A., Tachibana S., Lowney L.I., Hunkapiller M., Hood L.;
RT "Dynorphin-(1-13), an extraordinarily potent opioid peptide.";
RL Proc. Natl. Acad. Sci. U.S.A. 76:6666-6670(1979).
RN [3]
RP PROTEIN SEQUENCE OF 209-216, AND IDENTIFICATION OF DYNORPHIN A(1-8).
RC TISSUE=Hypothalamus;
RX PubMed=7191256; DOI=10.1016/s0006-291x(80)80063-5;
RA Minamino N., Kangawa K., Fukuda A., Matsuo H., Iagarashi M.;
RT "A new opioid octapeptide related to dynorphin from porcine hypothalamus.";
RL Biochem. Biophys. Res. Commun. 95:1475-1481(1980).
RN [4]
RP IDENTIFICATION OF LEUMORPHIN AND RIMORPHIN.
RX PubMed=6689399; DOI=10.1016/0006-291x(83)91653-4;
RA Nakao K., Suda M., Sakamoto M., Yoshimasa T., Morii N., Ikeda Y.,
RA Yanaihara C., Yanaihara N., Numa S., Imura H.;
RT "Leumorphin is a novel endogenous opioid peptide derived from
RT preproenkephalin B.";
RL Biochem. Biophys. Res. Commun. 117:695-701(1983).
CC -!- FUNCTION: Leu-enkephalins compete with and mimic the effects of opiate
CC drugs. They play a role in a number of physiologic functions, including
CC pain perception and responses to stress (By similarity). {ECO:0000250}.
CC -!- FUNCTION: Dynorphin peptides differentially regulate the kappa opioid
CC receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700
CC times more potent than Leu-enkephalin.
CC -!- FUNCTION: Leumorphin has a typical opiod activity and may have anti-
CC apoptotic effect. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- PTM: The N-terminal domain contains 6 conserved cysteines thought to be
CC involved in disulfide bonding and/or processing.
CC -!- SIMILARITY: Belongs to the opioid neuropeptide precursor family.
CC {ECO:0000305}.
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DR EMBL; V01362; CAA24650.1; -; mRNA.
DR PIR; A93280; DFPG.
DR RefSeq; NP_001004040.1; NM_001004040.1.
DR AlphaFoldDB; P01214; -.
DR BMRB; P01214; -.
DR STRING; 9823.ENSSSCP00000007643; -.
DR PaxDb; P01214; -.
DR PRIDE; P01214; -.
DR GeneID; 445529; -.
DR KEGG; ssc:445529; -.
DR CTD; 5173; -.
DR eggNOG; ENOG502RXT4; Eukaryota.
DR InParanoid; P01214; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR GO; GO:0043679; C:axon terminus; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0043025; C:neuronal cell body; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0001515; F:opioid peptide activity; IEA:UniProtKB-KW.
DR GO; GO:0031628; F:opioid receptor binding; IBA:GO_Central.
DR GO; GO:0007268; P:chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0007218; P:neuropeptide signaling pathway; IBA:GO_Central.
DR GO; GO:0007600; P:sensory perception; IBA:GO_Central.
DR InterPro; IPR006024; Opioid_neupept.
DR InterPro; IPR000750; Proenkphlin_B.
DR PANTHER; PTHR11438; PTHR11438; 1.
DR PANTHER; PTHR11438:SF4; PTHR11438:SF4; 1.
DR Pfam; PF01160; Opiods_neuropep; 1.
DR PRINTS; PR01028; OPIOIDPRCRSR.
DR PRINTS; PR01030; PENKBPRCRSR.
DR PROSITE; PS01252; OPIOIDS_PRECURSOR; 1.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Direct protein sequencing;
KW Disulfide bond; Endorphin; Neuropeptide; Neurotransmitter; Opioid peptide;
KW Reference proteome; Secreted; Signal.
FT SIGNAL 1..20
FT /evidence="ECO:0000255"
FT PROPEP 21..172
FT /id="PRO_0000008191"
FT PEPTIDE 175..184
FT /note="Alpha-neoendorphin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306358"
FT PEPTIDE 175..183
FT /note="Beta-neoendorphin"
FT /id="PRO_0000008192"
FT PEPTIDE 175..179
FT /note="Leu-enkephalin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306359"
FT PROPEP 186..206
FT /id="PRO_0000008193"
FT PEPTIDE 209..240
FT /note="Big dynorphin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306360"
FT PEPTIDE 209..225
FT /note="Dynorphin A(1-17)"
FT /id="PRO_0000306361"
FT PEPTIDE 209..221
FT /note="Dynorphin A(1-13)"
FT /id="PRO_0000306362"
FT PEPTIDE 209..216
FT /note="Dynorphin A(1-8)"
FT /id="PRO_0000306363"
FT PEPTIDE 209..213
FT /note="Leu-enkephalin"
FT /evidence="ECO:0000250"
FT /id="PRO_0000306364"
FT PEPTIDE 228..256
FT /note="Leumorphin"
FT /id="PRO_0000008195"
FT PEPTIDE 228..240
FT /note="Rimorphin"
FT /id="PRO_0000008196"
FT PEPTIDE 228..232
FT /note="Leu-enkephalin"
FT /id="PRO_0000008197"
FT VARIANT 147
FT /note="G -> E"
FT VARIANT 197
FT /note="R -> G"
SQ SEQUENCE 256 AA; 28617 MW; 6814412E3A8DB3AE CRC64;
MAWQGLLLAA CLLVLPSTMA DCLSGCSLCA VKTQDGPKPI NPLICSLECQ AALQPAEEWE
RCQGLLSFLA PLSLGLEGKE DLESKAALEE PSSELVKYMG PFLKELEKNR FLLSTPAEET
SLSRSLVEKL RSLPGRLGEE TESELMGDAQ QNDGAMEAAA LDSSVEDPKE QVKRYGGFLR
KYPKRSSEVA GEGDGDRDKV GHEDLYKRYG GFLRRIRPKL KWDNQKRYGG FLRRQFKVVT
RSQEDPNAYY EELFDV
