PDE6D_DROME
ID PDE6D_DROME Reviewed; 151 AA.
AC Q9VLJ0;
DT 16-DEC-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 138.
DE RecName: Full=Probable cGMP 3',5'-cyclic phosphodiesterase subunit delta;
DE Short=DmPrBP {ECO:0000303|PubMed:18503409};
GN Name=PrBP {ECO:0000303|PubMed:18503409}; ORFNames=CG9296;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1] {ECO:0000312|EMBL:AAF52700.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAF52700.1}
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [3] {ECO:0000312|EMBL:AAL48589.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley {ECO:0000312|EMBL:AAL49378.1};
RC TISSUE=Embryo {ECO:0000269|PubMed:12537569}, and
RC Head {ECO:0000269|PubMed:12537569};
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [4] {ECO:0000305}
RP INTERACTION WITH PDE6, AND SUBCELLULAR LOCATION.
RX PubMed=18503409; DOI=10.1042/bj20080560;
RA Day J.P., Cleghon V., Houslay M.D., Davies S.-A.;
RT "Regulation of a Drosophila melanogaster cGMP-specific phosphodiesterase by
RT prenylation and interaction with a prenyl-binding protein.";
RL Biochem. J. 414:363-374(2008).
CC -!- SUBUNIT: Interacts with Pde6. {ECO:0000269|PubMed:18503409}.
CC -!- INTERACTION:
CC Q9VLJ0; Q9VD64: dnd; NbExp=4; IntAct=EBI-181752, EBI-15113753;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:18503409}. Cytoplasm
CC {ECO:0000269|PubMed:18503409}. Note=Expressed predominantly in the
CC nucleus, with less intense staining in the cytoplasm.
CC -!- SIMILARITY: Belongs to the PDE6D/unc-119 family. {ECO:0000255}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AE014134; AAF52700.1; -; Genomic_DNA.
DR EMBL; AY070967; AAL48589.1; -; mRNA.
DR EMBL; AY071756; AAL49378.1; -; mRNA.
DR RefSeq; NP_609246.1; NM_135402.3.
DR AlphaFoldDB; Q9VLJ0; -.
DR SMR; Q9VLJ0; -.
DR BioGRID; 60315; 4.
DR IntAct; Q9VLJ0; 1.
DR STRING; 7227.FBpp0079352; -.
DR PaxDb; Q9VLJ0; -.
DR DNASU; 34196; -.
DR EnsemblMetazoa; FBtr0079750; FBpp0079352; FBgn0032059.
DR GeneID; 34196; -.
DR KEGG; dme:Dmel_CG9296; -.
DR UCSC; CG9296-RA; d. melanogaster.
DR CTD; 34196; -.
DR FlyBase; FBgn0032059; PrBP.
DR VEuPathDB; VectorBase:FBgn0032059; -.
DR eggNOG; KOG4038; Eukaryota.
DR GeneTree; ENSGT00390000000263; -.
DR HOGENOM; CLU_119682_0_0_1; -.
DR InParanoid; Q9VLJ0; -.
DR OMA; FKGRCLE; -.
DR OrthoDB; 1192412at2759; -.
DR PhylomeDB; Q9VLJ0; -.
DR Reactome; R-DME-9648002; RAS processing.
DR BioGRID-ORCS; 34196; 1 hit in 1 CRISPR screen.
DR GenomeRNAi; 34196; -.
DR PRO; PR:Q9VLJ0; -.
DR Proteomes; UP000000803; Chromosome 2L.
DR Bgee; FBgn0032059; Expressed in seminal fluid secreting gland and 22 other tissues.
DR ExpressionAtlas; Q9VLJ0; baseline and differential.
DR Genevisible; Q9VLJ0; DM.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0016319; P:mushroom body development; IMP:FlyBase.
DR GO; GO:0050953; P:sensory perception of light stimulus; IEA:InterPro.
DR Gene3D; 2.70.50.40; -; 1.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR008015; PDED_dom.
DR InterPro; IPR037036; PDED_dom_sf.
DR InterPro; IPR017287; Rhodop-sen_GMP-Pdiesterase_dsu.
DR Pfam; PF05351; GMP_PDE_delta; 1.
DR PIRSF; PIRSF037825; GMP-Pdiesterase_delta; 1.
DR SUPFAM; SSF81296; SSF81296; 1.
PE 1: Evidence at protein level;
KW cGMP; Cytoplasm; Nucleus; Reference proteome.
FT CHAIN 1..151
FT /note="Probable cGMP 3',5'-cyclic phosphodiesterase subunit
FT delta"
FT /id="PRO_0000358315"
SQ SEQUENCE 151 AA; 17404 MW; C7ED52D77C5F458C CRC64;
MGSDDQSAGD RIQKGFQINY MILRDADSGK IIWQENKDFS APDQEHEARV PVKILDMRAV
SREINFSTIE SMENFRLDQK VLFKGRIMEE WFFEMGFVGA NTTNTWQSTI EAAPESQMMP
AKVLNGNVTI QTSFYDNETL ITKSVVRLYY I
