ID   PANC_SCHPO              Reviewed;         283 AA.
AC   Q09673;
DT   01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1995, sequence version 1.
DT   25-MAY-2022, entry version 133.
DE   RecName: Full=Pantoate--beta-alanine ligase;
DE            EC=6.3.2.1;
DE   AltName: Full=Pantoate-activating enzyme;
DE   AltName: Full=Pantothenate synthetase;
GN   Name=pan6; ORFNames=SPAC5H10.08c;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(R)-pantoate + ATP + beta-alanine = (R)-pantothenate + AMP +
CC         diphosphate + H(+); Xref=Rhea:RHEA:10912, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:15980, ChEBI:CHEBI:29032, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:33019, ChEBI:CHEBI:57966, ChEBI:CHEBI:456215; EC=6.3.2.1;
CC   -!- PATHWAY: Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-
CC       pantothenate from (R)-pantoate and beta-alanine: step 1/1.
CC   -!- SIMILARITY: Belongs to the pantothenate synthetase family.
CC       {ECO:0000305}.
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DR   EMBL; CU329670; CAA89958.1; -; Genomic_DNA.
DR   PIR; S55486; S55486.
DR   RefSeq; NP_592821.1; NM_001018221.2.
DR   AlphaFoldDB; Q09673; -.
DR   SMR; Q09673; -.
DR   BioGRID; 278115; 3.
DR   STRING; 4896.SPAC5H10.08c.1; -.
DR   MaxQB; Q09673; -.
DR   PaxDb; Q09673; -.
DR   EnsemblFungi; SPAC5H10.08c.1; SPAC5H10.08c.1:pep; SPAC5H10.08c.
DR   GeneID; 2541618; -.
DR   KEGG; spo:SPAC5H10.08c; -.
DR   PomBase; SPAC5H10.08c; pan6.
DR   VEuPathDB; FungiDB:SPAC5H10.08c; -.
DR   eggNOG; KOG3042; Eukaryota.
DR   HOGENOM; CLU_047148_0_0_1; -.
DR   InParanoid; Q09673; -.
DR   OMA; SRNKYLC; -.
DR   PhylomeDB; Q09673; -.
DR   UniPathway; UPA00028; UER00005.
DR   PRO; PR:Q09673; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0005634; C:nucleus; ISO:PomBase.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0004592; F:pantoate-beta-alanine ligase activity; ISO:PomBase.
DR   GO; GO:0015940; P:pantothenate biosynthetic process; IGI:PomBase.
DR   CDD; cd00560; PanC; 1.
DR   Gene3D; 3.30.1300.10; -; 1.
DR   Gene3D; 3.40.50.620; -; 1.
DR   HAMAP; MF_00158; PanC; 1.
DR   InterPro; IPR004821; Cyt_trans-like.
DR   InterPro; IPR003721; Pantoate_ligase.
DR   InterPro; IPR042176; Pantoate_ligase_C.
DR   InterPro; IPR014729; Rossmann-like_a/b/a_fold.
DR   PANTHER; PTHR21299:SF1; PTHR21299:SF1; 1.
DR   Pfam; PF02569; Pantoate_ligase; 1.
DR   TIGRFAMs; TIGR00125; cyt_tran_rel; 1.
DR   TIGRFAMs; TIGR00018; panC; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Ligase; Nucleotide-binding; Pantothenate biosynthesis;
KW   Reference proteome.
FT   CHAIN           1..283
FT                   /note="Pantoate--beta-alanine ligase"
FT                   /id="PRO_0000128297"
SQ   SEQUENCE   283 AA;  31877 MW;  97EE26E911FF4AD7 CRC64;
     MQVLKEKLLI HQQVDNWRKD GNRIAFVPTM GNLHEGHFSL VREAKRHAEK VVVSIFVNPM
     QFNNPQDLLL YPRTMDQDCS QLQNLGVDLV YAPTVEELYP EGSQDITFVD VPKLSTMLEG
     ASRPGHFRGV TTVVSKLFHI VNPDVACFGE KDFQQVAIIK KMVRDLNFFI EIIQVPIVRA
     DDGLALSSRN GYLTSEERKI APNLYKILKK LAQELSNGNG DLEKLIAETN TELSRCRFIP
     DQLEICDSTT LEPFTAGTKN VVILAAAWLG KARLIDNIQT TIN