PADR_BACSU
ID PADR_BACSU Reviewed; 182 AA.
AC P94443; Q796Z4;
DT 20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1997, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Negative transcription regulator PadR;
GN Name=padR; Synonyms=yfiO; OrderedLocusNames=BSU08340;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / AC327;
RX PubMed=8973323; DOI=10.1016/s0378-1119(96)00495-7;
RA Yamamoto H., Uchiyama S., Sekiguchi J.;
RT "The Bacillus subtilis chromosome region near 78 degrees contains the genes
RT encoding a new two-component system, three ABC transporters and a lipase.";
RL Gene 181:147-151(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP FUNCTION.
RX PubMed=11073918; DOI=10.1128/jb.182.23.6724-6731.2000;
RA Barthelmebs L., Lecomte B., Divies C., Cavin J.-F.;
RT "Inducible metabolism of phenolic acids in Pediococcus pentosaceus is
RT encoded by an autoregulated operon which involves a new class of negative
RT transcriptional regulator.";
RL J. Bacteriol. 182:6724-6731(2000).
RN [4]
RP FUNCTION.
RX PubMed=18326577; DOI=10.1128/jb.01936-07;
RA Tran N.P., Gury J., Dartois V., Nguyen T.K.C., Seraut H., Barthelmebs L.,
RA Gervais P., Cavin J.-F.;
RT "Phenolic acid-mediated regulation of the padC gene, encoding the phenolic
RT acid decarboxylase of Bacillus subtilis.";
RL J. Bacteriol. 190:3213-3224(2008).
CC -!- FUNCTION: Negative transcriptional regulator of padC phenolic acid
CC decarboxylase. {ECO:0000269|PubMed:11073918,
CC ECO:0000269|PubMed:18326577}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000305}.
CC -!- MISCELLANEOUS: Phenolic acids regulate PadR repression activity, by
CC impairing it's binding to the padC promoter.
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DR EMBL; D78508; BAA11405.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB12663.1; -; Genomic_DNA.
DR PIR; B69804; B69804.
DR RefSeq; NP_388715.1; NC_000964.3.
DR RefSeq; WP_003233588.1; NZ_JNCM01000032.1.
DR PDB; 7CBV; X-ray; 2.30 A; A/B=1-182.
DR PDBsum; 7CBV; -.
DR AlphaFoldDB; P94443; -.
DR SMR; P94443; -.
DR STRING; 224308.BSU08340; -.
DR PaxDb; P94443; -.
DR PRIDE; P94443; -.
DR EnsemblBacteria; CAB12663; CAB12663; BSU_08340.
DR GeneID; 936174; -.
DR KEGG; bsu:BSU08340; -.
DR PATRIC; fig|224308.179.peg.901; -.
DR eggNOG; COG1695; Bacteria.
DR InParanoid; P94443; -.
DR OMA; QFGHYLV; -.
DR PhylomeDB; P94443; -.
DR BioCyc; BSUB:BSU08340-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR Gene3D; 1.10.10.10; -; 1.
DR InterPro; IPR018309; Tscrpt_reg_PadR_C.
DR InterPro; IPR005149; Tscrpt_reg_PadR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR Pfam; PF03551; PadR; 1.
DR Pfam; PF10400; Vir_act_alpha_C; 1.
DR SUPFAM; SSF46785; SSF46785; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Repressor; Transcription;
KW Transcription regulation.
FT CHAIN 1..182
FT /note="Negative transcription regulator PadR"
FT /id="PRO_0000360549"
FT HELIX 5..11
FT /evidence="ECO:0007829|PDB:7CBV"
FT HELIX 12..14
FT /evidence="ECO:0007829|PDB:7CBV"
FT HELIX 19..27
FT /evidence="ECO:0007829|PDB:7CBV"
FT TURN 28..33
FT /evidence="ECO:0007829|PDB:7CBV"
FT HELIX 38..50
FT /evidence="ECO:0007829|PDB:7CBV"
FT STRAND 53..57
FT /evidence="ECO:0007829|PDB:7CBV"
FT STRAND 69..72
FT /evidence="ECO:0007829|PDB:7CBV"
FT HELIX 74..85
FT /evidence="ECO:0007829|PDB:7CBV"
FT HELIX 97..103
FT /evidence="ECO:0007829|PDB:7CBV"
FT HELIX 105..107
FT /evidence="ECO:0007829|PDB:7CBV"
FT HELIX 110..138
FT /evidence="ECO:0007829|PDB:7CBV"
FT HELIX 152..179
FT /evidence="ECO:0007829|PDB:7CBV"
SQ SEQUENCE 182 AA; 21222 MW; C5CE26256944838D CRC64;
MRVLKYAILG LLRKGELSGY DITSYFKEEL GQFWSAKHSQ IYPELKKLTD EGFITFRTTI
QGTKLEKKMY TLTDSGKQEL HDWLIRHQPI PETVKDEFML KAYFISCLSR QEASDLFKDQ
LQKRQAKLSD LQGSYEKLMA SAEPMSFSSP DFGHYLVLTK ALEREKNYVS WLESILAMID
KD
