ID   OSR2_DANRE              Reviewed;         238 AA.
AC   Q567J8;
DT   19-JAN-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-MAY-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Protein odd-skipped-related 2 {ECO:0000312|EMBL:AAH93148.1};
DE            Short=zOsr2 {ECO:0000303|PubMed:17011543};
GN   Name=osr2 {ECO:0000312|ZFIN:ZDB-GENE-050417-183}; ORFNames=zgc:111995;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1] {ECO:0000312|EMBL:AAH93148.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Olfactory epithelium {ECO:0000312|EMBL:AAH93148.1};
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=17011543; DOI=10.1016/j.ydbio.2006.08.063;
RA   Tena J.J., Neto A., de la Calle-Mustienes E., Bras-Pereira C., Casares F.,
RA   Gomez-Skarmeta J.L.;
RT   "Odd-skipped genes encode repressors that control kidney development.";
RL   Dev. Biol. 301:518-531(2007).
CC   -!- FUNCTION: Transcriptional repressor (By similarity). Required for
CC       pronephric kidney development. {ECO:0000250|UniProtKB:Q32NK7,
CC       ECO:0000269|PubMed:17011543}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q32NK7}.
CC   -!- TISSUE SPECIFICITY: At the 8-somite stage, expressed in the pronephros,
CC       with weak generalized expression elsewhere. At 24 hpf, expressed in the
CC       kidney tubules and the anterior duct, and also in the gut. At 60 hpf,
CC       expressed in the tubules and the pectoral fin buds.
CC       {ECO:0000269|PubMed:17011543}.
CC   -!- DISRUPTION PHENOTYPE: Embryos show a down-regulation of early
CC       pronephric markers lhx1a/lim1 and pax2a/pax2.1, and subsequent defects
CC       in renal structures. In addition, embryos at 72 hpf display pericardial
CC       edemas and kidney cysts characteristic of kidney failure.
CC       {ECO:0000269|PubMed:17011543}.
CC   -!- SIMILARITY: Belongs to the Odd C2H2-type zinc-finger protein family.
CC       {ECO:0000255}.
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DR   EMBL; BC093148; AAH93148.1; -; mRNA.
DR   RefSeq; NP_001017694.1; NM_001017694.1.
DR   AlphaFoldDB; Q567J8; -.
DR   SMR; Q567J8; -.
DR   STRING; 7955.ENSDARP00000055394; -.
DR   PaxDb; Q567J8; -.
DR   GeneID; 550389; -.
DR   KEGG; dre:550389; -.
DR   CTD; 116039; -.
DR   ZFIN; ZDB-GENE-050417-183; osr2.
DR   eggNOG; KOG1721; Eukaryota.
DR   InParanoid; Q567J8; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q567J8; -.
DR   PRO; PR:Q567J8; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0001822; P:kidney development; IDA:ZFIN.
DR   GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IMP:UniProtKB.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IMP:UniProtKB.
DR   GO; GO:0033339; P:pectoral fin development; IMP:ZFIN.
DR   GO; GO:0048793; P:pronephros development; IDA:ZFIN.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   GO; GO:0001655; P:urogenital system development; IBA:GO_Central.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 3.
DR   SMART; SM00355; ZnF_C2H2; 3.
DR   SUPFAM; SSF57667; SSF57667; 2.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE   2: Evidence at transcript level;
KW   Developmental protein; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..238
FT                   /note="Protein odd-skipped-related 2"
FT                   /id="PRO_0000390732"
FT   ZN_FING         134..156
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         162..184
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         190..212
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          105..126
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   238 AA;  26570 MW;  03285463F6592BA6 CRC64;
     MGSKTLPAPV PLHPAPQLNY SLLRTLNAFP VAVDQLYGLS ALHTVQMNRW TVGFPQLQGL
     ADPRFPGALP FPAAAAHLLP HKHPVHRKDR PRFDFANLAV AATQEDPPVT GQSRLSPERR
     PARGRLPAKS KKEFICRFCG RHFTKSYNLL IHERTHTDER PYTCDICHKA FRRQDHLRDH
     RYIHSKEKPF KCQECGKGFC QSRTLAVHKT LHLQTSSLSA AAAAGRCFGA TATCGATV