ID   OSPG_SHIF2              Reviewed;         196 AA.
AC   D2AJU3;
DT   10-AUG-2010, integrated into UniProtKB/Swiss-Prot.
DT   09-FEB-2010, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Protein kinase OspG;
DE            EC=2.7.-.-;
DE   AltName: Full=Effector protein OspG;
GN   Name=ospG; OrderedLocusNames=SFxv_5079;
OS   Shigella flexneri serotype X (strain 2002017).
OG   Plasmid pSFxv_1.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Enterobacteriaceae; Shigella.
OX   NCBI_TaxID=591020;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=2002017;
RX   PubMed=19955273; DOI=10.1128/jcm.00614-09;
RA   Ye C., Lan R., Xia S., Zhang J., Sun Q., Zhang S., Jing H., Wang L., Li Z.,
RA   Zhou Z., Zhao A., Cui Z., Cao J., Jin D., Huang L., Wang Y., Luo X.,
RA   Bai X., Wang Y., Wang P., Xu Q., Xu J.;
RT   "Emergence of a new multidrug-resistant serotype X variant in an epidemic
RT   clone of Shigella flexneri.";
RL   J. Clin. Microbiol. 48:419-426(2010).
CC   -!- FUNCTION: Effector proteins function to alter host cell physiology and
CC       promote bacterial survival in host tissues. This protein is a kinase
CC       that is involved in down-regulation of the host innate response induced
CC       by invasive bacteria (By similarity). {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}. Host cell {ECO:0000250}.
CC       Note=Secreted via Mxi-Spa type III secretion system (TTSS), and
CC       delivered into the host cell. {ECO:0000250}.
CC   -!- PTM: Autophosphorylated. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the protein kinase superfamily. {ECO:0000305}.
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DR   EMBL; CP001384; ADA76974.1; -; Genomic_DNA.
DR   RefSeq; WP_000705601.1; NC_017319.1.
DR   AlphaFoldDB; D2AJU3; -.
DR   SMR; D2AJU3; -.
DR   EnsemblBacteria; ADA76974; ADA76974; SFxv_5079.
DR   KEGG; sfe:SFxv_5079; -.
DR   PATRIC; fig|591020.3.peg.5450; -.
DR   HOGENOM; CLU_120872_0_0_6; -.
DR   OMA; YTEYYSA; -.
DR   Proteomes; UP000001884; Plasmid pSFxv_1.
DR   GO; GO:0005615; C:extracellular space; ISS:UniProtKB.
DR   GO; GO:0043657; C:host cell; IEA:UniProtKB-SubCell.
DR   GO; GO:0016301; F:kinase activity; ISS:UniProtKB.
DR   GO; GO:0046777; P:protein autophosphorylation; ISS:UniProtKB.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   SUPFAM; SSF56112; SSF56112; 1.
PE   3: Inferred from homology;
KW   Kinase; Phosphoprotein; Plasmid; Secreted; Transferase; Virulence.
FT   CHAIN           1..196
FT                   /note="Protein kinase OspG"
FT                   /id="PRO_0000395879"
SQ   SEQUENCE   196 AA;  22570 MW;  E90908CB43BCB28A CRC64;
     MKITSTIIQT PFPFENNNSH AGIVTEPILG KLIGQGSTAE IFEDVNDSSA LYKKYDLIGN
     QYNEILEMAW QESELFNAFY GDEASVVIQY GGDVYLRMLR VPGTPLSDID TADIPDNIES
     LYLQLICKLN ELSIIHYDLN TGNMLYDKES ESLFPIDFRN IYAEYYAATK KDKEIIDRRL
     QMRTNDFYSL LNRKYL