OR5L2_HUMAN
ID OR5L2_HUMAN Reviewed; 311 AA.
AC Q8NGL0; Q6IF66; Q96RB2;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Olfactory receptor 5L2;
DE AltName: Full=HTPCRX16;
DE AltName: Full=Olfactory receptor OR11-153;
GN Name=OR5L2;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 68-283.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 126-237.
RC TISSUE=Testis;
RX PubMed=1370859; DOI=10.1038/355453a0;
RA Parmentier M., Libert F., Schurmans S., Schiffmann S., Lefort A.,
RA Eggerickx D., Ledent C., Mollereau C., Gerard C., Perret J., Grootegoed A.,
RA Vassart G.;
RT "Expression of members of the putative olfactory receptor gene family in
RT mammalian germ cells.";
RL Nature 355:453-455(1992).
RN [4]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [5]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="http://genome.weizmann.ac.il/horde/card/index/symbol:OR5L2";
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DR EMBL; AB065782; BAC06002.1; -; Genomic_DNA.
DR EMBL; AF399526; AAK95011.1; -; Genomic_DNA.
DR EMBL; X64990; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BK004396; DAA04794.1; -; Genomic_DNA.
DR CCDS; CCDS31511.1; -.
DR RefSeq; NP_001004739.1; NM_001004739.1.
DR AlphaFoldDB; Q8NGL0; -.
DR SMR; Q8NGL0; -.
DR STRING; 9606.ENSP00000367650; -.
DR GlyGen; Q8NGL0; 2 sites.
DR PhosphoSitePlus; Q8NGL0; -.
DR BioMuta; OR5L2; -.
DR DMDM; 38372719; -.
DR MassIVE; Q8NGL0; -.
DR PaxDb; Q8NGL0; -.
DR PeptideAtlas; Q8NGL0; -.
DR PRIDE; Q8NGL0; -.
DR Antibodypedia; 53546; 77 antibodies from 14 providers.
DR DNASU; 26338; -.
DR Ensembl; ENST00000378397.1; ENSP00000367650.1; ENSG00000205030.1.
DR GeneID; 26338; -.
DR KEGG; hsa:26338; -.
DR MANE-Select; ENST00000378397.1; ENSP00000367650.1; NM_001004739.1; NP_001004739.1.
DR UCSC; uc001nhy.1; human.
DR CTD; 26338; -.
DR GeneCards; OR5L2; -.
DR HGNC; HGNC:8351; OR5L2.
DR HPA; ENSG00000205030; Not detected.
DR neXtProt; NX_Q8NGL0; -.
DR OpenTargets; ENSG00000205030; -.
DR PharmGKB; PA32545; -.
DR VEuPathDB; HostDB:ENSG00000205030; -.
DR eggNOG; ENOG502T9KN; Eukaryota.
DR GeneTree; ENSGT01050000244804; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q8NGL0; -.
DR OMA; RVELTSC; -.
DR OrthoDB; 954078at2759; -.
DR PhylomeDB; Q8NGL0; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGL0; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 26338; 15 hits in 636 CRISPR screens.
DR GeneWiki; OR5L2; -.
DR GenomeRNAi; 26338; -.
DR Pharos; Q8NGL0; Tdark.
DR PRO; PR:Q8NGL0; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGL0; protein.
DR Bgee; ENSG00000205030; Expressed in amniotic fluid.
DR Genevisible; Q8NGL0; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..311
FT /note="Olfactory receptor 5L2"
FT /id="PRO_0000150603"
FT TOPO_DOM 1..25
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 26..46
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 47..54
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 55..75
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 76..99
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 121..139
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 140..160
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 161..196
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..311
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 195
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 97..189
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 59
FT /note="V -> M (in dbSNP:rs56711116)"
FT /id="VAR_062045"
FT VARIANT 81
FT /note="M -> R (in dbSNP:rs17148058)"
FT /id="VAR_034229"
SQ SEQUENCE 311 AA; 34682 MW; C680187C542C27DA CRC64;
MGKENCTTVA EFILLGLSDV PELRVCLFLL FLLIYGVTLL ANLGMTALIQ VSSRLHTPVY
FFLSHLSFVD FCYSSIIVPK MLANIFNKDK AISFLGCMVQ FYLFCTCGVT EVFLLAVMAY
DRFVAICNPL LYMVTMSQKL RVELTSCCYF CGTVCSLIHS SLALRILFYR SNVINHFFCD
LPPLLSLACS DVTVNETLLF LVATLNESVT IMIILTSYLL ILTTILKIHS AESRHKAFST
CASHLTAITV SHGTILYIYC RPSSGNSGDV DKVATVFYTV VIPMLNPLIY SLRNKDVNKA
LRKVMGSKIH S
