OR5DI_HUMAN
ID OR5DI_HUMAN Reviewed; 313 AA.
AC Q8NGL1; Q6IF67; Q6IFD3; Q96RB3;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=Olfactory receptor 5D18;
DE AltName: Full=Olfactory receptor OR11-143;
DE AltName: Full=Olfactory receptor OR11-152;
GN Name=OR5D18;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Suwa M., Sato T., Okouchi I., Arita M., Futami K., Matsumoto S.,
RA Tsutsumi S., Aburatani H., Asai K., Akiyama Y.;
RT "Genome-wide discovery and analysis of human seven transmembrane helix
RT receptor genes.";
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND VARIANT ASP-136.
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-136.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 69-284, AND VARIANT ASP-136.
RX PubMed=12213199; DOI=10.1006/geno.2002.6830;
RA Fuchs T., Malecova B., Linhart C., Sharan R., Khen M., Herwig R.,
RA Shmulevich D., Elkon R., Steinfath M., O'Brien J.K., Radelof U.,
RA Lehrach H., Lancet D., Shamir R.;
RT "DEFOG: a practical scheme for deciphering families of genes.";
RL Genomics 80:295-302(2002).
RN [5]
RP IDENTIFICATION.
RX PubMed=14983052; DOI=10.1073/pnas.0307882100;
RA Malnic B., Godfrey P.A., Buck L.B.;
RT "The human olfactory receptor gene family.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:2584-2589(2004).
RN [6]
RP ERRATUM OF PUBMED:14983052.
RA Malnic B., Godfrey P.A., Buck L.B.;
RL Proc. Natl. Acad. Sci. U.S.A. 101:7205-7205(2004).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- WEB RESOURCE: Name=Human Olfactory Receptor Data Exploratorium (HORDE);
CC URL="https://genome.weizmann.ac.il/horde/card/index/symbol:OR5D18/term:OR5D18/type:keyword";
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DR EMBL; AB065781; BAC06001.1; -; Genomic_DNA.
DR EMBL; CH471076; EAW73685.1; -; Genomic_DNA.
DR EMBL; BC136925; AAI36926.1; -; mRNA.
DR EMBL; BC136927; AAI36928.1; -; mRNA.
DR EMBL; AF399525; AAK95010.1; -; Genomic_DNA.
DR EMBL; BK004395; DAA04793.1; -; Genomic_DNA.
DR EMBL; BK004329; DAA04727.1; -; Genomic_DNA.
DR CCDS; CCDS31510.1; -.
DR RefSeq; NP_001001952.1; NM_001001952.1.
DR AlphaFoldDB; Q8NGL1; -.
DR SMR; Q8NGL1; -.
DR STRING; 9606.ENSP00000335025; -.
DR GlyGen; Q8NGL1; 1 site.
DR iPTMnet; Q8NGL1; -.
DR PhosphoSitePlus; Q8NGL1; -.
DR BioMuta; OR5D18; -.
DR DMDM; 38372720; -.
DR MassIVE; Q8NGL1; -.
DR PaxDb; Q8NGL1; -.
DR PeptideAtlas; Q8NGL1; -.
DR PRIDE; Q8NGL1; -.
DR Antibodypedia; 77336; 4 antibodies from 4 providers.
DR DNASU; 219438; -.
DR Ensembl; ENST00000333976.7; ENSP00000335025.4; ENSG00000186119.9.
DR GeneID; 219438; -.
DR KEGG; hsa:219438; -.
DR MANE-Select; ENST00000333976.7; ENSP00000335025.4; NM_001001952.1; NP_001001952.1.
DR UCSC; uc010rin.2; human.
DR CTD; 219438; -.
DR GeneCards; OR5D18; -.
DR HGNC; HGNC:15285; OR5D18.
DR HPA; ENSG00000186119; Not detected.
DR neXtProt; NX_Q8NGL1; -.
DR PharmGKB; PA32521; -.
DR VEuPathDB; HostDB:ENSG00000186119; -.
DR eggNOG; ENOG502SJBD; Eukaryota.
DR GeneTree; ENSGT01050000244804; -.
DR HOGENOM; CLU_012526_5_5_1; -.
DR InParanoid; Q8NGL1; -.
DR OMA; PGCVVQF; -.
DR OrthoDB; 1059975at2759; -.
DR PhylomeDB; Q8NGL1; -.
DR TreeFam; TF352753; -.
DR PathwayCommons; Q8NGL1; -.
DR Reactome; R-HSA-9752946; Expression and translocation of olfactory receptors.
DR BioGRID-ORCS; 219438; 11 hits in 638 CRISPR screens.
DR GeneWiki; OR5D18; -.
DR GenomeRNAi; 219438; -.
DR Pharos; Q8NGL1; Tdark.
DR PRO; PR:Q8NGL1; -.
DR Proteomes; UP000005640; Chromosome 11.
DR RNAct; Q8NGL1; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007608; P:sensory perception of smell; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..313
FT /note="Olfactory receptor 5D18"
FT /id="PRO_0000150594"
FT TOPO_DOM 1..26
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 27..47
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 48..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..100
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 101..121
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 122..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..197
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 198..218
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 219..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..272
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 273..293
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..313
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 7
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 98..190
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT VARIANT 36
FT /note="Y -> C (in dbSNP:rs7948629)"
FT /id="VAR_048046"
FT VARIANT 118
FT /note="V -> M (in dbSNP:rs11231180)"
FT /id="VAR_034224"
FT VARIANT 136
FT /note="N -> D (in dbSNP:rs297081)"
FT /evidence="ECO:0000269|PubMed:12213199,
FT ECO:0000269|PubMed:15489334, ECO:0000269|Ref.2"
FT /id="VAR_048047"
FT VARIANT 270
FT /note="H -> R (in dbSNP:rs55832853)"
FT /id="VAR_062042"
SQ SEQUENCE 313 AA; 35348 MW; 97C8EF3B0A6F259A CRC64;
MLLTDRNTSG TTFTLLGFSD YPELQVPLFL VFLAIYNVTV LGNIGLIVII KINPKLHTPM
YFFLSQLSFV DFCYSSIIAP KMLVNLVVKD RTISFLGCVV QFFFFCTFVV TESFLLAVMA
YDRFVAICNP LLYTVNMSQK LCVLLVVGSY AWGVSCSLEL TCSALKLCFH GFNTINHFFC
EFSSLLSLSC SDTYINQWLL FFLATFNEIS TLLIVLTSYA FIVVTILKMR SVSGRRKAFS
TCASHLTAIT IFHGTILFLY CVPNSKNSRH TVKVASVFYT VVIPMLNPLI YSLRNKDVKD
TVTEILDTKV FSY
