ID   OPGH_WIGBR              Reviewed;         826 AA.
AC   Q8D3D5;
DT   25-JUL-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2003, sequence version 1.
DT   25-MAY-2022, entry version 84.
DE   RecName: Full=Glucans biosynthesis glucosyltransferase H {ECO:0000255|HAMAP-Rule:MF_01072};
DE            EC=2.4.1.- {ECO:0000255|HAMAP-Rule:MF_01072};
GN   Name=mdoH {ECO:0000255|HAMAP-Rule:MF_01072};
GN   Synonyms=opgH {ECO:0000255|HAMAP-Rule:MF_01072};
GN   OrderedLocusNames=WIGBR0660;
OS   Wigglesworthia glossinidia brevipalpis.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC   Erwiniaceae; Wigglesworthia.
OX   NCBI_TaxID=36870;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=12219091; DOI=10.1038/ng986;
RA   Akman L., Yamashita A., Watanabe H., Oshima K., Shiba T., Hattori M.,
RA   Aksoy S.;
RT   "Genome sequence of the endocellular obligate symbiont of tsetse flies,
RT   Wigglesworthia glossinidia.";
RL   Nat. Genet. 32:402-407(2002).
CC   -!- FUNCTION: Involved in the biosynthesis of osmoregulated periplasmic
CC       glucans (OPGs). {ECO:0000255|HAMAP-Rule:MF_01072}.
CC   -!- PATHWAY: Glycan metabolism; osmoregulated periplasmic glucan (OPG)
CC       biosynthesis. {ECO:0000255|HAMAP-Rule:MF_01072}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000255|HAMAP-
CC       Rule:MF_01072}; Multi-pass membrane protein {ECO:0000255|HAMAP-
CC       Rule:MF_01072}.
CC   -!- SIMILARITY: Belongs to the glycosyltransferase 2 family. OpgH
CC       subfamily. {ECO:0000255|HAMAP-Rule:MF_01072}.
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DR   EMBL; BA000021; BAC24212.1; -; Genomic_DNA.
DR   RefSeq; WP_011069870.1; NC_004344.2.
DR   AlphaFoldDB; Q8D3D5; -.
DR   STRING; 36870.25166021; -.
DR   CAZy; GT2; Glycosyltransferase Family 2.
DR   EnsemblBacteria; BAC24212; BAC24212; BAC24212.
DR   KEGG; wbr:mdoH; -.
DR   eggNOG; COG2943; Bacteria.
DR   HOGENOM; CLU_015730_0_0_6; -.
DR   OMA; TAGLHYW; -.
DR   OrthoDB; 1049243at2; -.
DR   UniPathway; UPA00637; -.
DR   Proteomes; UP000000562; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016758; F:hexosyltransferase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0009250; P:glucan biosynthetic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 3.90.550.10; -; 1.
DR   HAMAP; MF_01072; MdoH_OpgH; 1.
DR   InterPro; IPR023725; Glucans_biosynth_gluTrFase_H.
DR   InterPro; IPR001173; Glyco_trans_2-like.
DR   InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR   Pfam; PF00535; Glycos_transf_2; 1.
DR   SUPFAM; SSF53448; SSF53448; 1.
PE   3: Inferred from homology;
KW   Cell inner membrane; Cell membrane; Glycosyltransferase; Membrane;
KW   Reference proteome; Transferase; Transmembrane; Transmembrane helix.
FT   CHAIN           1..826
FT                   /note="Glucans biosynthesis glucosyltransferase H"
FT                   /id="PRO_0000210366"
FT   TRANSMEM        137..159
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        174..192
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        199..221
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        518..540
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        547..569
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        573..595
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        602..624
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        628..645
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        665..684
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
FT   TRANSMEM        688..710
FT                   /note="Helical"
FT                   /evidence="ECO:0000255|HAMAP-Rule:MF_01072"
SQ   SEQUENCE   826 AA;  97076 MW;  4F3D16C6CC8A9461 CRC64;
     MTNNKNYMKF LKFYNKKNKI KKIKNCSYKK LFCMNHYLRT GSNKRKKFLK KQYISTISVK
     KRLKCAWPKL INCSNFIIKD KKNIPLIKSY PKINRTSIAP TPWVIDSIFS FLKKFFFKKQ
     NSKILSKNKK KKYLEKWEIV GIIRRYVFLI LILSQTSIAT YKLNSILPYK DISWSYTIYL
     FNKNIFLIIK YFSPYILQIF VLILFYILFF WVSASFWTAF MGFYQLITKK DEYNISNKSI
     VKEIKKNHRT AILMPICNED VERVFAGLRA TYESILSTGK IKFFDIYILS DSYNTDICMS
     EQKSWIDLCS ETGFIGNIFY RRRNRRVKQK SGNIDDFCRR WGKNYSYMVI LDADSIMSGK
     CLVKLVSLME SNPRAGIIQS IPKASGMNTL YARYHQFSTR VYGPLFTAGM HFWQLGESHY
     WGHNAIIRIK PFIKYCVLSP LPGNGIFSGS ILSHDFVEAA LMRRAGWSVW IAYDIPGSYE
     EPPPNLLDEL KRDRRWCHGN LMNFRLFFMN GLHPVHRVVF LTGVMSYLSA PLWFAFLILS
     TILQIIYNIE FMCCFKINSY FYIIPYLHLE ASIGLFFITL LLLLLPKFFS VILIISKNSI
     QYGGTRCFIL SIILEIFLSM MFSPIKMMFH TFFIFRAFFG FSLSWKSPKR RDFSTSWKES
     IKSHIVQVVI GLIWSFLIIF FMTIKSLFIF FPIIFSLIIS PLISVYSSYV KIGLIFKNFG
     LLLIPEEKYP PKEIINTKKY FKINKNKSLK NGFFQAILHP VYNALAVAMA SSRHNSSILI
     DLNRKKFLDL ILIKGLNKLN MIEKLTVLND PIILTKLHFI YLLNNQ