OL492_MOUSE
ID OL492_MOUSE Reviewed; 314 AA.
AC Q8VFD1;
DT 10-OCT-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Olfactory receptor 492;
DE AltName: Full=Olfactory receptor 204-18;
GN Name=Olfr492; Synonyms=Mor204-18;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [3]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
CC -!- FUNCTION: Potential odorant receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AY073600; AAL61263.1; -; Genomic_DNA.
DR EMBL; AY317600; AAP70995.1; -; Genomic_DNA.
DR CCDS; CCDS85376.1; -.
DR RefSeq; NP_666708.1; NM_146497.1.
DR AlphaFoldDB; Q8VFD1; -.
DR SMR; Q8VFD1; -.
DR GlyGen; Q8VFD1; 2 sites.
DR PRIDE; Q8VFD1; -.
DR Ensembl; ENSMUST00000079865; ENSMUSP00000146417; ENSMUSG00000109497.
DR GeneID; 258490; -.
DR KEGG; mmu:258490; -.
DR UCSC; uc009jcg.1; mouse.
DR CTD; 258490; -.
DR MGI; MGI:3030326; Olfr492.
DR VEuPathDB; HostDB:ENSMUSG00000109497; -.
DR GeneTree; ENSGT01050000244860; -.
DR InParanoid; Q8VFD1; -.
DR OMA; VEKHTIA; -.
DR OrthoDB; 999769at2759; -.
DR PhylomeDB; Q8VFD1; -.
DR BioGRID-ORCS; 258490; 4 hits in 13 CRISPR screens.
DR PRO; PR:Q8VFD1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8VFD1; protein.
DR Bgee; ENSMUSG00000109497; Expressed in undifferentiated genital tubercle.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..314
FT /note="Olfactory receptor 492"
FT /id="PRO_0000150847"
FT TOPO_DOM 1..28
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 29..49
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 50..57
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 58..78
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 79..102
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 103..123
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 124..136
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 137..157
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 158..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..240
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 241..261
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 262..274
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 275..295
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 296..314
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 8
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 100..192
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 314 AA; 34717 MW; 6DB1A4EB76B8C795 CRC64;
MAFLEDGNHT AVTEFILLGL TDDPVLRVIL FTIILCIYLV TVSGNLSTIL LIRVSSQLHH
PMYFFLSHVG SVDIGYSSSV TPNMLVNFLV EKHTIAYLGC GIQLSSAAFF GTAECFLLAT
MAYDRFVAIC NPLLYSTKMS TQTCIQLVVG SYTGGILNAS FAIISFFSFL FCGPNRINHF
YCDFAPLVEL SCSDINVSVV ITTIFSASVT IITVFVIAIS YTYILITILK MRSTEGRHKA
FSTCTSYLTA VTLFYGTVTF IYVVPKSNYS TDQNKVASVF YIVVIPMLNP LIYSLRNNDI
KGALKRQLGK KTFS
