OL145_MOUSE
ID OL145_MOUSE Reviewed; 310 AA.
AC Q60882; Q9EQB0;
DT 15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT 24-JAN-2006, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Olfactory receptor 145;
DE AltName: Full=Odorant receptor K21;
DE AltName: Full=Olfactory receptor 161-6;
DE AltName: Full=Olfactory receptor 7C;
GN Name=Olfr145; Synonyms=Mor161-6, Olfr7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=11130974; DOI=10.1007/s003350010217;
RA Xie S.Y., Feinstein P., Mombaerts P.;
RT "Characterization of a cluster comprising 100 odorant receptor genes in
RT mouse.";
RL Mamm. Genome 11:1070-1078(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11802173; DOI=10.1038/nn800;
RA Zhang X., Firestein S.;
RT "The olfactory receptor gene superfamily of the mouse.";
RL Nat. Neurosci. 5:124-133(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11875048; DOI=10.1093/hmg/11.5.535;
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RT "Different evolutionary processes shaped the mouse and human olfactory
RT receptor gene families.";
RL Hum. Mol. Genet. 11:535-546(2002).
RN [4]
RP ERRATUM OF PUBMED:11875048.
RA Young J.M., Friedman C., Williams E.M., Ross J.A., Tonnes-Priddy L.,
RA Trask B.J.;
RL Hum. Mol. Genet. 11:1683-1683(2002).
RN [5]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 127-238.
RC STRAIN=C57BL/6J;
RX PubMed=8570653; DOI=10.1073/pnas.93.2.884;
RA Sullivan S.L., Adamson M.C., Ressler K.J., Kozak C.A., Buck L.B.;
RT "The chromosomal distribution of mouse odorant receptor genes.";
RL Proc. Natl. Acad. Sci. U.S.A. 93:884-888(1996).
CC -!- FUNCTION: Odorant receptor. {ECO:0000305}.
CC -!- SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF282279; AAG39864.1; -; Genomic_DNA.
DR EMBL; AY073780; AAL61443.1; -; Genomic_DNA.
DR EMBL; AY318060; AAP71357.1; -; Genomic_DNA.
DR EMBL; U28771; AAC52394.1; -; Genomic_DNA.
DR CCDS; CCDS22990.1; -.
DR RefSeq; NP_666425.1; NM_146313.1.
DR AlphaFoldDB; Q60882; -.
DR SMR; Q60882; -.
DR STRING; 10090.ENSMUSP00000083229; -.
DR BindingDB; Q60882; -.
DR GlyGen; Q60882; 1 site.
DR PaxDb; Q60882; -.
DR PRIDE; Q60882; -.
DR Antibodypedia; 53986; 70 antibodies from 20 providers.
DR DNASU; 258310; -.
DR Ensembl; ENSMUST00000086062; ENSMUSP00000083229; ENSMUSG00000066748.
DR Ensembl; ENSMUST00000213688; ENSMUSP00000150284; ENSMUSG00000066748.
DR GeneID; 258310; -.
DR KEGG; mmu:258310; -.
DR UCSC; uc009ovp.1; mouse.
DR CTD; 258310; -.
DR MGI; MGI:2177528; Olfr145.
DR VEuPathDB; HostDB:ENSMUSG00000066748; -.
DR eggNOG; ENOG502QVH7; Eukaryota.
DR GeneTree; ENSGT01010000222320; -.
DR HOGENOM; CLU_012526_1_0_1; -.
DR InParanoid; Q60882; -.
DR OMA; AMTHTAC; -.
DR OrthoDB; 1077225at2759; -.
DR PhylomeDB; Q60882; -.
DR TreeFam; TF352753; -.
DR BioGRID-ORCS; 258310; 1 hit in 65 CRISPR screens.
DR ChiTaRS; Olfr145; mouse.
DR PRO; PR:Q60882; -.
DR Proteomes; UP000000589; Chromosome 9.
DR RNAct; Q60882; protein.
DR Bgee; ENSMUSG00000066748; Expressed in epithelium and 12 other tissues.
DR ExpressionAtlas; Q60882; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; ISA:MGI.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR GO; GO:0005549; F:odorant binding; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; ISA:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; ISA:MGI.
DR GO; GO:0007608; P:sensory perception of smell; ISA:MGI.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR000725; Olfact_rcpt.
DR Pfam; PF13853; 7tm_4; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00245; OLFACTORYR.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Olfaction; Receptor; Reference proteome; Sensory transduction;
KW Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Olfactory receptor 145"
FT /id="PRO_0000150822"
FT TOPO_DOM 1..27
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 28..48
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 49..55
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 56..76
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 77..98
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 99..119
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 120..140
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 141..161
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 162..195
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 196..216
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 217..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..270
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..291
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 292..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 5
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 96..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 34451 MW; E9C6E3C269BFA6DD CRC64;
MATENASVPE FILAGLTDQP GLRMPLFFLF LGFYMVTMVG NLGLITLIGL NSHLHTPMYF
FLFNLSLIDF CYSTVITPKM LVSFVSKKNI ISYSGCMTQL FFFLFFVVSE SFILSAMAYD
RYVAICNPLM YTVTMSPQVC LLLLLGVYVM GFAGAMAHTA FMVKLTFCAD KLVNHYMCDI
LPLLERSCTS TYVNELVVFI VVGIDIGVPT VTIFISYALI LSSILRISST EGRSKAFSTC
SSHIIAVSLF FGSGAFMYLK PSSLLPMNQG KVSSLFYTIV VPMLNPLIYS LRNKDVKVAL
RKTLSRSSFS
