ID   ARSD_HALSA              Reviewed;         108 AA.
AC   O52028;
DT   14-MAY-2014, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 95.
DE   RecName: Full=Putative arsenical resistance operon repressor ArsD;
GN   Name=arsD; OrderedLocusNames=VNG_5181G;
OS   Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)
OS   (Halobacterium halobium).
OG   Plasmid pNRC100.
OC   Archaea; Euryarchaeota; Stenosarchaea group; Halobacteria; Halobacteriales;
OC   Halobacteriaceae; Halobacterium.
OX   NCBI_TaxID=64091;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=9847077; DOI=10.1101/gr.8.11.1131;
RA   Ng W.V., Ciufo S.A., Smith T.M., Bumgarner R.E., Baskin D., Faust J.,
RA   Hall B., Loretz C., Seto J., Slagel J., Hood L., DasSarma S.;
RT   "Snapshot of a large dynamic replicon in a halophilic archaeon: megaplasmid
RT   or minichromosome?";
RL   Genome Res. 8:1131-1141(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=11016950; DOI=10.1073/pnas.190337797;
RA   Ng W.V., Kennedy S.P., Mahairas G.G., Berquist B., Pan M., Shukla H.D.,
RA   Lasky S.R., Baliga N.S., Thorsson V., Sbrogna J., Swartzell S., Weir D.,
RA   Hall J., Dahl T.A., Welti R., Goo Y.A., Leithauser B., Keller K., Cruz R.,
RA   Danson M.J., Hough D.W., Maddocks D.G., Jablonski P.E., Krebs M.P.,
RA   Angevine C.M., Dale H., Isenbarger T.A., Peck R.F., Pohlschroder M.,
RA   Spudich J.L., Jung K.-H., Alam M., Freitas T., Hou S., Daniels C.J.,
RA   Dennis P.P., Omer A.D., Ebhardt H., Lowe T.M., Liang P., Riley M., Hood L.,
RA   DasSarma S.;
RT   "Genome sequence of Halobacterium species NRC-1.";
RL   Proc. Natl. Acad. Sci. U.S.A. 97:12176-12181(2000).
RN   [3]
RP   INDUCTION, AND DISRUPTION PHENOTYPE.
RC   STRAIN=ATCC 700922 / JCM 11081 / NRC-1;
RX   PubMed=15126481; DOI=10.1128/jb.186.10.3187-3194.2004;
RA   Wang G., Kennedy S.P., Fasiludeen S., Rensing C., DasSarma S.;
RT   "Arsenic resistance in Halobacterium sp. strain NRC-1 examined by using an
RT   improved gene knockout system.";
RL   J. Bacteriol. 186:3187-3194(2004).
CC   -!- FUNCTION: Trans-acting repressor of the arsADRC operon. {ECO:0000250}.
CC   -!- INDUCTION: By arsenite and antimonite. {ECO:0000269|PubMed:15126481}.
CC   -!- DISRUPTION PHENOTYPE: Deletion of the arsADRC operon results in
CC       increased sensitivity to arsenite and antimonite but not arsenate.
CC       {ECO:0000269|PubMed:15126481}.
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DR   EMBL; AF016485; AAC82908.1; -; Genomic_DNA.
DR   PIR; T08341; T08341.
DR   RefSeq; WP_010890457.1; NZ_BK010830.1.
DR   AlphaFoldDB; O52028; -.
DR   SMR; O52028; -.
DR   EnsemblBacteria; AAC82908; AAC82908; AAC82908.
DR   GeneID; 5954938; -.
DR   GeneID; 62888361; -.
DR   KEGG; hal:arsD; -.
DR   HOGENOM; CLU_120868_1_0_2; -.
DR   InParanoid; O52028; -.
DR   OMA; DVDWAKQ; -.
DR   OrthoDB; 101440at2157; -.
DR   PhylomeDB; O52028; -.
DR   Proteomes; UP000000554; Plasmid pNRC100.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; IEA:InterPro.
DR   GO; GO:0046685; P:response to arsenic-containing substance; IEA:UniProtKB-KW.
DR   InterPro; IPR010712; Arsenical-R_ArsD.
DR   Pfam; PF06953; ArsD; 1.
PE   2: Evidence at transcript level;
KW   Arsenical resistance; DNA-binding; Plasmid; Reference proteome; Repressor;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..108
FT                   /note="Putative arsenical resistance operon repressor ArsD"
FT                   /id="PRO_0000429113"
SQ   SEQUENCE   108 AA;  12024 MW;  64C7441A6D03D4FA CRC64;
     MTQLTLYEEA MCCSTGVCGP DPDDELVEVS AALDQLENEF DVDVSRANMQ HNIEQFLETQ
     QIADLVEEHG PSILPITVVN DEIVARETYL SYDELASTFE DSPDPQEA