ID   O162_CONLT              Reviewed;          80 AA.
AC   Q2I2R3; Q3YEG5;
DT   15-JAN-2008, integrated into UniProtKB/Swiss-Prot.
DT   07-MAR-2006, sequence version 1.
DT   25-MAY-2022, entry version 33.
DE   RecName: Full=Conotoxin Lt6.2;
DE   AltName: Full=Conotoxin LeD41;
DE   AltName: Full=Lt6b;
DE   Flags: Precursor;
OS   Conus litteratus (Lettered cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Elisaconus.
OX   NCBI_TaxID=89445;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RX   PubMed=16908117; DOI=10.1016/j.ygeno.2006.06.014;
RA   Pi C., Liu J., Peng C., Liu Y., Jiang X., Zhao Y., Tang S., Wang L.,
RA   Dong M., Chen S., Xu A.;
RT   "Diversity and evolution of conotoxins based on gene expression profiling
RT   of Conus litteratus.";
RL   Genomics 88:809-819(2006).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom duct;
RA   Luo S., Zhangsun D., Zhang B., Lin Q.;
RT   "Novel O-superfamily conotoxins, and their coding polynucleotides and
RT   use.";
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin. {ECO:0000250}.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; DQ345369; ABC74977.1; -; mRNA.
DR   EMBL; DQ141148; AAZ83749.1; -; mRNA.
DR   AlphaFoldDB; Q2I2R3; -.
DR   SMR; Q2I2R3; -.
DR   ConoServer; 1110; LtVIB precursor.
DR   ConoServer; 1155; LtVIB precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008200; F:ion channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   Pfam; PF02950; Conotoxin; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Knottin; Secreted; Signal; Toxin.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..47
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000315494"
FT   PEPTIDE         48..80
FT                   /note="Conotoxin Lt6.2"
FT                   /id="PRO_0000315495"
FT   DISULFID        48..62
FT                   /evidence="ECO:0000250"
FT   DISULFID        55..66
FT                   /evidence="ECO:0000250"
FT   DISULFID        61..73
FT                   /evidence="ECO:0000250"
FT   CONFLICT        5
FT                   /note="R -> C (in Ref. 2; AAZ83749)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   80 AA;  9267 MW;  2B269C31F03438B8 CRC64;
     MKLTRVLIIA VLFLTAYQLT TVETYSRGKW MHRALRSTGK NPKVTRECSS PDESCTYHYN
     CCQLYCNKEE NVCLENSPEV