ID   O161_CONAJ              Reviewed;          78 AA.
AC   P0CB09;
DT   28-JUL-2009, integrated into UniProtKB/Swiss-Prot.
DT   28-JUL-2009, sequence version 1.
DT   25-MAY-2022, entry version 26.
DE   RecName: Full=Delta-conotoxin-like Ai6.1;
DE   Flags: Precursor;
OS   Conus ammiralis (Admiral cone).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Caenogastropoda; Neogastropoda; Conoidea; Conidae; Conus; Cylinder.
OX   NCBI_TaxID=97188;
RN   [1]
RP   NUCLEOTIDE SEQUENCE.
RA   Hillyard D.R., Mcintosh M.J., Jones R.M., Cartier E.G., Watkins M.,
RA   Olivera B.M., Layer R.T.;
RT   "O-superfamily conotoxin peptides.";
RL   Patent number JP2003533178, 11-NOV-2003.
CC   -!- FUNCTION: Delta-conotoxins bind to site 6 of voltage-gated sodium
CC       channels (Nav) and inhibit the inactivation process. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom duct.
CC   -!- DOMAIN: The presence of a 'disulfide through disulfide knot'
CC       structurally defines this protein as a knottin.
CC   -!- DOMAIN: The cysteine framework is VI/VII (C-C-CC-C-C).
CC   -!- SIMILARITY: Belongs to the conotoxin O1 superfamily. {ECO:0000305}.
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DR   EMBL; DJ379394; -; NOT_ANNOTATED_CDS; Unassigned_DNA.
DR   AlphaFoldDB; P0CB09; -.
DR   ConoServer; 3028; Ai6.1 precursor.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0019871; F:sodium channel inhibitor activity; IEA:InterPro.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   InterPro; IPR004214; Conotoxin.
DR   InterPro; IPR012322; Conotoxin_d-typ_CS.
DR   Pfam; PF02950; Conotoxin; 1.
DR   PROSITE; PS60005; DELTA_CONOTOXIN; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond;
KW   Ion channel impairing toxin; Knottin; Neurotoxin; Secreted; Signal; Toxin;
KW   Voltage-gated sodium channel impairing toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   PROPEP          23..49
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000380620"
FT   PEPTIDE         52..78
FT                   /note="Delta-conotoxin-like Ai6.1"
FT                   /id="PRO_0000380621"
FT   DISULFID        53..68
FT                   /evidence="ECO:0000250"
FT   DISULFID        60..72
FT                   /evidence="ECO:0000250"
FT   DISULFID        67..77
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   78 AA;  8742 MW;  D8600F5B80630A35 CRC64;
     MKLTCVMIVA VLFLTAWTFA TADDPRNGLG NLFSNAHHEM KNPEASKLNK RWCKQSGEMC
     NLLDQNCCEG YCIVLVCT