ID   ARPC3_CAEEL             Reviewed;         183 AA.
AC   Q9XWV3;
DT   01-DEC-2000, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=Probable actin-related protein 2/3 complex subunit 3;
DE   AltName: Full=Arp2/3 complex 21 kDa subunit;
DE            Short=p21-ARC;
GN   Name=arx-5; ORFNames=Y37D8A.1;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Functions as component of the Arp2/3 complex which is
CC       involved in regulation of actin polymerization and together with an
CC       activating nucleation-promoting factor (NPF) mediates the formation of
CC       branched actin networks. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the Arp2/3 complex. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the ARPC3 family. {ECO:0000305}.
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DR   EMBL; AL032626; CAA21538.1; -; Genomic_DNA.
DR   PIR; T26637; T26637.
DR   RefSeq; NP_499667.1; NM_067266.3.
DR   AlphaFoldDB; Q9XWV3; -.
DR   SMR; Q9XWV3; -.
DR   BioGRID; 41872; 11.
DR   IntAct; Q9XWV3; 1.
DR   STRING; 6239.Y37D8A.1; -.
DR   EPD; Q9XWV3; -.
DR   PaxDb; Q9XWV3; -.
DR   PeptideAtlas; Q9XWV3; -.
DR   EnsemblMetazoa; Y37D8A.1.1; Y37D8A.1.1; WBGene00000203.
DR   GeneID; 176697; -.
DR   KEGG; cel:CELE_Y37D8A.1; -.
DR   UCSC; Y37D8A.1; c. elegans.
DR   CTD; 176697; -.
DR   WormBase; Y37D8A.1; CE20206; WBGene00000203; arx-5.
DR   eggNOG; KOG3155; Eukaryota.
DR   GeneTree; ENSGT00390000018018; -.
DR   HOGENOM; CLU_094365_1_0_1; -.
DR   InParanoid; Q9XWV3; -.
DR   OMA; TPSKWWL; -.
DR   OrthoDB; 1451115at2759; -.
DR   PhylomeDB; Q9XWV3; -.
DR   Reactome; R-CEL-2029482; Regulation of actin dynamics for phagocytic cup formation.
DR   Reactome; R-CEL-3928662; EPHB-mediated forward signaling.
DR   Reactome; R-CEL-5663213; RHO GTPases Activate WASPs and WAVEs.
DR   Reactome; R-CEL-8856828; Clathrin-mediated endocytosis.
DR   PRO; PR:Q9XWV3; -.
DR   Proteomes; UP000001940; Chromosome III.
DR   Bgee; WBGene00000203; Expressed in pharyngeal muscle cell (C elegans) and 4 other tissues.
DR   GO; GO:0005885; C:Arp2/3 protein complex; IBA:GO_Central.
DR   GO; GO:0005737; C:cytoplasm; HDA:WormBase.
DR   GO; GO:0055120; C:striated muscle dense body; HDA:WormBase.
DR   GO; GO:0003779; F:actin binding; IEA:UniProtKB-KW.
DR   GO; GO:0034314; P:Arp2/3 complex-mediated actin nucleation; IBA:GO_Central.
DR   GO; GO:0010631; P:epithelial cell migration; IMP:WormBase.
DR   GO; GO:0016331; P:morphogenesis of embryonic epithelium; IMP:WormBase.
DR   GO; GO:0030833; P:regulation of actin filament polymerization; IEA:InterPro.
DR   Gene3D; 1.10.1760.10; -; 1.
DR   InterPro; IPR007204; ARPC3.
DR   InterPro; IPR036753; ARPC3_sf.
DR   PANTHER; PTHR12391; PTHR12391; 1.
DR   Pfam; PF04062; P21-Arc; 1.
DR   PIRSF; PIRSF016315; ARP2/3_P21-Arc; 1.
DR   SUPFAM; SSF69060; SSF69060; 1.
PE   3: Inferred from homology;
KW   Actin-binding; Cytoplasm; Cytoskeleton; Reference proteome.
FT   CHAIN           1..183
FT                   /note="Probable actin-related protein 2/3 complex subunit
FT                   3"
FT                   /id="PRO_0000124044"
SQ   SEQUENCE   183 AA;  21043 MW;  57ABF2734FA1436D CRC64;
     MPAYHSKFDT ELKVLPLGNT NMGKLPIRTN FKGPAPQTNQ DDIIDEALTY FKPNIFFREF
     EIKGPADRTM IYLIFYITEC LRKLQKSPNK IAGQKDLHAL ALSHLLPIPG ENGFPLNSMY
     KAPQSKPDED EMRAYLQQIR QEIGARLCDL AFPDPQDRPS KWWLCFARRR FMDKGLVGQG
     VNL