ARP4_CANAL
ID ARP4_CANAL Reviewed; 468 AA.
AC Q5AC48; A0A1D8PQ46; Q5ABS7;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2017, sequence version 3.
DT 03-AUG-2022, entry version 94.
DE RecName: Full=Actin-related protein 4;
DE AltName: Full=Actin-like protein ARP4;
DE Short=Actin-like protein 4;
GN Name=ARP4; OrderedLocusNames=CAALFM_C603350CA;
GN ORFNames=CaO19.13069, CaO19.5623;
OS Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX NCBI_TaxID=237561;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA Scherer S.;
RT "The diploid genome sequence of Candida albicans.";
RL Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA Chibana H., Nantel A., Magee P.T.;
RT "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT on the eight chromosomes.";
RL Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC STRAIN=SC5314 / ATCC MYA-2876;
RX PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT specific measurements and provides a simple model for repeat and indel
RT structure.";
RL Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC -!- FUNCTION: Chromatin interaction component of the NuA4 histone
CC acetyltransferase complex which is involved in transcriptional
CC activation of selected genes principally by acetylation of nucleosomal
CC histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is
CC required for NuA4 complex integrity. Component of the SWR1 complex
CC which mediates the ATP-dependent exchange of histone H2A for the H2A
CC variant HZT1 leading to transcriptional regulation of selected genes by
CC chromatin remodeling. Component of the INO80 complex which remodels
CC chromatin by shifting nucleosomes and is involved in DNA repair (By
CC similarity). {ECO:0000250}.
CC -!- SUBUNIT: Component of the NuA4 histone acetyltransferase complex, of
CC the INO80 chromatin remodeling complex, and of the SWR1 chromatin
CC remodeling complex. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the actin family. ARP4 subfamily. {ECO:0000305}.
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DR EMBL; CP017628; AOW30265.1; -; Genomic_DNA.
DR RefSeq; XP_719183.2; XM_714090.2.
DR AlphaFoldDB; Q5AC48; -.
DR SMR; Q5AC48; -.
DR STRING; 237561.Q5AC48; -.
DR PRIDE; Q5AC48; -.
DR GeneID; 3639201; -.
DR KEGG; cal:CAALFM_C603350CA; -.
DR CGD; CAL0000192300; ARP4.
DR VEuPathDB; FungiDB:C6_03350C_A; -.
DR eggNOG; KOG0679; Eukaryota.
DR HOGENOM; CLU_027965_6_2_1; -.
DR InParanoid; Q5AC48; -.
DR OrthoDB; 649708at2759; -.
DR PRO; PR:Q5AC48; -.
DR Proteomes; UP000000559; Chromosome 6.
DR GO; GO:0031011; C:Ino80 complex; IEA:EnsemblFungi.
DR GO; GO:0035267; C:NuA4 histone acetyltransferase complex; IBA:GO_Central.
DR GO; GO:0016514; C:SWI/SNF complex; IBA:GO_Central.
DR GO; GO:0000812; C:Swr1 complex; IEA:EnsemblFungi.
DR GO; GO:0003682; F:chromatin binding; IBA:GO_Central.
DR GO; GO:0004402; F:histone acetyltransferase activity; IEA:EnsemblFungi.
DR GO; GO:0042393; F:histone binding; IEA:EnsemblFungi.
DR GO; GO:0006338; P:chromatin remodeling; IEA:EnsemblFungi.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0043967; P:histone H4 acetylation; IBA:GO_Central.
DR GO; GO:0051382; P:kinetochore assembly; IEA:EnsemblFungi.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR004000; Actin.
DR InterPro; IPR004001; Actin_CS.
DR InterPro; IPR043129; ATPase_NBD.
DR PANTHER; PTHR11937; PTHR11937; 1.
DR Pfam; PF00022; Actin; 1.
DR SMART; SM00268; ACTIN; 1.
DR SUPFAM; SSF53067; SSF53067; 2.
DR PROSITE; PS00432; ACTINS_2; 1.
PE 3: Inferred from homology;
KW Activator; Chromatin regulator; DNA damage; DNA repair; Nucleus;
KW Reference proteome; Transcription; Transcription regulation.
FT CHAIN 1..468
FT /note="Actin-related protein 4"
FT /id="PRO_0000089093"
FT REGION 262..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..360
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 335..353
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 468 AA; 52658 MW; 784DC4D571CFDBE7 CRC64;
MATASTTTVY GGDEINAIVL DPGSYTTRIG YAGDDFPKVI TSSYYGQVKN DKKKIFGESI
NVPRANYDIK PILKESIIVD WDAAIEQYQY YFDQQLKVVG PEQPILITEP IWTETSYRQQ
LVETFFENFE FSGIYLAKSP TCVSFQQGRS NCLVVDLGHD SVSVTPVIDG ICLLKSSMKT
NYGGKFLSNE IQDYLIDTKK VVMEPSFKIK SKIPTTYPDP PKYELKNNNT IPTSSSSSLS
QSFLEFQNEK IYHNFKEILE VPEKNSSSGT TTTTTTTNKD SSRLFELPTG QSIVIDRFKI
AESIFDPTIY KFTNSKLSFP PNNGEISITQ ANEYRPLKRV RKNDDEEEDS NQSTPKPEVN
IRGISQLISH TLSNIDIDLR ASLANNIIVT GGVSLISQLT ERLYLELSNN NPGLKIRLHA
VGNSTERINQ AWIGGSVLAS LGTFHQMWVT KEEYNEVGVD RILNQRFR
