ID   AROS_XENTR              Reviewed;         149 AA.
AC   Q28IC1;
DT   20-JAN-2009, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Active regulator of SIRT1;
DE   AltName: Full=40S ribosomal protein S19-binding protein 1;
DE            Short=RPS19-binding protein 1;
DE            Short=S19BP;
GN   Name=rps19bp1; Synonyms=aros; ORFNames=TNeu074g06.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (NOV-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Direct regulator of SIRT1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the AROS family. {ECO:0000305}.
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DR   EMBL; CR760483; CAJ83072.1; -; mRNA.
DR   EMBL; BC155375; AAI55376.1; -; mRNA.
DR   RefSeq; NP_001037897.1; NM_001044432.1.
DR   AlphaFoldDB; Q28IC1; -.
DR   SMR; Q28IC1; -.
DR   PaxDb; Q28IC1; -.
DR   PRIDE; Q28IC1; -.
DR   Ensembl; ENSXETT00000077989; ENSXETP00000067412; ENSXETG00000037536.
DR   Ensembl; ENSXETT00000099065; ENSXETP00000083675; ENSXETG00000037536.
DR   GeneID; 733497; -.
DR   KEGG; xtr:733497; -.
DR   CTD; 91582; -.
DR   Xenbase; XB-GENE-5779332; rps19bp1.
DR   HOGENOM; CLU_194935_0_0_1; -.
DR   InParanoid; Q28IC1; -.
DR   OrthoDB; 1513987at2759; -.
DR   Proteomes; UP000008143; Chromosome 4.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000037536; Expressed in early embryo and 15 other tissues.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0019899; F:enzyme binding; IBA:GO_Central.
DR   InterPro; IPR023262; AROS.
DR   PANTHER; PTHR31454; PTHR31454; 1.
DR   Pfam; PF15684; AROS; 1.
DR   PRINTS; PR02029; ACTREGSIRT1.
PE   2: Evidence at transcript level;
KW   Nucleus; Reference proteome.
FT   CHAIN           1..149
FT                   /note="Active regulator of SIRT1"
FT                   /id="PRO_0000361539"
FT   REGION          1..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        24..44
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   149 AA;  17154 MW;  BDBA8AA462D82F94 CRC64;
     MSVSLLRKGL DLLREERSGA ESSSKKRNSS SKPKPCLSSS KTGMRKQLRR LKQQGLRHDQ
     KATAKGRVIR SAVEEFKKQS AKDHLQQNLQ YMLDSSSVTS KEVVDKILKQ NRGRKAKDIE
     IKQHRQIKEK SVFSDADFKR FELEYFGSK