NUDC3_MOUSE
ID NUDC3_MOUSE Reviewed; 363 AA.
AC Q8R1N4; Q3TX16; Q5SVV6; Q5SVV7; Q6PFE4; Q6ZPZ2; Q8BL70; Q8BWN3; Q8BWW5;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 23-NOV-2004, sequence version 3.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=NudC domain-containing protein 3;
GN Name=Nudcd3; Synonyms=Kiaa1068;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
RC TISSUE=Brain;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
RC STRAIN=C57BL/6J, and NOD;
RC TISSUE=Corpora quadrigemina, Pancreas, Spinal cord, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=FVB/N; TISSUE=Brain, Kidney, and Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q8R1N4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8R1N4-2; Sequence=VSP_013678;
CC Name=3;
CC IsoId=Q8R1N4-3; Sequence=VSP_013679, VSP_013680;
CC Name=4;
CC IsoId=Q8R1N4-4; Sequence=VSP_013677;
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC98086.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK129276; BAC98086.1; ALT_INIT; mRNA.
DR EMBL; AK046219; BAC32642.1; -; mRNA.
DR EMBL; AK049739; BAC33899.1; -; mRNA.
DR EMBL; AK050476; BAC34277.1; -; mRNA.
DR EMBL; AK159391; BAE35045.1; -; mRNA.
DR EMBL; AK159458; BAE35100.1; -; mRNA.
DR EMBL; AK169797; BAE41373.1; -; mRNA.
DR EMBL; AK170329; BAE41723.1; -; mRNA.
DR EMBL; AK171224; BAE42326.1; -; mRNA.
DR EMBL; AL607152; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AL611926; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC024322; AAH24322.3; -; mRNA.
DR EMBL; BC037090; AAH37090.1; -; mRNA.
DR EMBL; BC057603; AAH57603.1; -; mRNA.
DR CCDS; CCDS24412.1; -. [Q8R1N4-1]
DR RefSeq; NP_776109.1; NM_173748.4. [Q8R1N4-1]
DR RefSeq; XP_006514666.1; XM_006514603.2.
DR AlphaFoldDB; Q8R1N4; -.
DR SMR; Q8R1N4; -.
DR BioGRID; 229094; 8.
DR IntAct; Q8R1N4; 1.
DR STRING; 10090.ENSMUSP00000064668; -.
DR iPTMnet; Q8R1N4; -.
DR PhosphoSitePlus; Q8R1N4; -.
DR EPD; Q8R1N4; -.
DR MaxQB; Q8R1N4; -.
DR PaxDb; Q8R1N4; -.
DR PeptideAtlas; Q8R1N4; -.
DR PRIDE; Q8R1N4; -.
DR ProteomicsDB; 287848; -. [Q8R1N4-1]
DR ProteomicsDB; 287849; -. [Q8R1N4-2]
DR ProteomicsDB; 287850; -. [Q8R1N4-3]
DR ProteomicsDB; 287851; -. [Q8R1N4-4]
DR Antibodypedia; 13393; 104 antibodies from 24 providers.
DR DNASU; 209586; -.
DR Ensembl; ENSMUST00000066496; ENSMUSP00000064668; ENSMUSG00000053838. [Q8R1N4-1]
DR GeneID; 209586; -.
DR KEGG; mmu:209586; -.
DR UCSC; uc007hxy.2; mouse. [Q8R1N4-1]
DR UCSC; uc007hxz.2; mouse. [Q8R1N4-2]
DR UCSC; uc007hya.2; mouse. [Q8R1N4-3]
DR CTD; 23386; -.
DR MGI; MGI:2144158; Nudcd3.
DR VEuPathDB; HostDB:ENSMUSG00000053838; -.
DR eggNOG; KOG2265; Eukaryota.
DR GeneTree; ENSGT00940000158444; -.
DR HOGENOM; CLU_047332_0_0_1; -.
DR InParanoid; Q8R1N4; -.
DR OMA; RNTDFYH; -.
DR PhylomeDB; Q8R1N4; -.
DR TreeFam; TF300147; -.
DR BioGRID-ORCS; 209586; 25 hits in 74 CRISPR screens.
DR ChiTaRS; Nudcd3; mouse.
DR PRO; PR:Q8R1N4; -.
DR Proteomes; UP000000589; Chromosome 11.
DR RNAct; Q8R1N4; protein.
DR Bgee; ENSMUSG00000053838; Expressed in dentate gyrus of hippocampal formation granule cell and 245 other tissues.
DR ExpressionAtlas; Q8R1N4; baseline and differential.
DR Genevisible; Q8R1N4; MM.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005868; C:cytoplasmic dynein complex; ISO:MGI.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; ISO:MGI.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:1905793; P:protein localization to pericentriolar material; ISO:MGI.
DR CDD; cd06495; p23_NUDCD3_like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR037898; NudC_fam.
DR InterPro; IPR025934; NudC_N_dom.
DR InterPro; IPR027761; NUDCD3.
DR InterPro; IPR037905; p23_NUDCD3.
DR PANTHER; PTHR12356; PTHR12356; 1.
DR PANTHER; PTHR12356:SF19; PTHR12356:SF19; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF14050; Nudc_N; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS51203; CS; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome.
FT CHAIN 1..363
FT /note="NudC domain-containing protein 3"
FT /id="PRO_0000057986"
FT DOMAIN 187..279
FT /note="CS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT REGION 120..143
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 125..143
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 342
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IVD9"
FT MOD_RES 357
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8IVD9"
FT VAR_SEQ 1..295
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14621295"
FT /id="VSP_013677"
FT VAR_SEQ 217..264
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_013678"
FT VAR_SEQ 266..300
FT /note="NLSKVGEYWWSAILEGEEPIDIDKINKERSMATVD -> SEVTCVQSSHQGF
FT APAMMTCVQVFPIISEVFNYSN (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_013679"
FT VAR_SEQ 301..363
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_013680"
SQ SEQUENCE 363 AA; 40890 MW; D5FD1DE3CB724042 CRC64;
MEPGAAELYD QALLGILQHV GNVQDFLRVL FGFLYRKTDF YRLLRHPSDR MGFPPGAAQA
LVLQVFKTFD HMARQDDEKR KKELEEKIRK KEEEAKALPA AETEKVAVPV PVQEVEIDAA
ADLSGPQEVE KEEPPGSQDP EHTVTHGLEK AEAPGTVSSA AEGPKDPPVL PRIQEQFQKN
PDSYNGAIRE NYIWSQDYTD LEVRVPVPKH VMKGKQVSVA LSSGTIRVAM VEENGERVLM
EGKLTHKINT ESSLWSLEPG RCVLVNLSKV GEYWWSAILE GEEPIDIDKI NKERSMATVD
EEEQAVLDRL TFDYHQKLQG KPQSHELKVH EMLKKGWDAE GSPFRGQRFD PAMFNISPGA
VQF
