NUDC3_HUMAN
ID NUDC3_HUMAN Reviewed; 361 AA.
AC Q8IVD9; Q9BTI3; Q9H7W9; Q9UPT4;
DT 10-MAY-2005, integrated into UniProtKB/Swiss-Prot.
DT 17-APR-2007, sequence version 3.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=NudC domain-containing protein 3;
GN Name=NUDCD3; Synonyms=KIAA1068;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=12853948; DOI=10.1038/nature01782;
RA Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H.,
RA Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K.,
RA Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A.,
RA Delehaunty K.D., Miner T.L., Nash W.E., Cordes M., Du H., Sun H.,
RA Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A.,
RA Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P.,
RA Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M.,
RA Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S.,
RA Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R.,
RA Strowmatt C., Latreille P., Miller N., Johnson D., Murray J.,
RA Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W.,
RA Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A.,
RA Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E.,
RA Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E.,
RA Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A.,
RA Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A.,
RA Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R.,
RA McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H.,
RA Wilson R.K.;
RT "The DNA sequence of human chromosome 7.";
RL Nature 424:157-164(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS PRO-3 AND CYS-235.
RC TISSUE=Brain, Pancreas, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 8-361.
RC TISSUE=Brain;
RX PubMed=10470851; DOI=10.1093/dnares/6.3.197;
RA Kikuno R., Nagase T., Ishikawa K., Hirosawa M., Miyajima N., Tanaka A.,
RA Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIV. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:197-205(1999).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 103-361.
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-146, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryonic kidney;
RX PubMed=17525332; DOI=10.1126/science.1140321;
RA Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E.,
RA Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y.,
RA Gygi S.P., Elledge S.J.;
RT "ATM and ATR substrate analysis reveals extensive protein networks
RT responsive to DNA damage.";
RL Science 316:1160-1166(2007).
RN [6]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
RN [7]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-355, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=20068231; DOI=10.1126/scisignal.2000475;
RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L.,
RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.;
RT "Quantitative phosphoproteomics reveals widespread full phosphorylation
RT site occupancy during mitosis.";
RL Sci. Signal. 3:RA3-RA3(2010).
RN [8]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
RN [9]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-340, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=23186163; DOI=10.1021/pr300630k;
RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J.,
RA Mohammed S.;
RT "Toward a comprehensive characterization of a human cancer cell
RT phosphoproteome.";
RL J. Proteome Res. 12:260-271(2013).
RN [10]
RP STRUCTURE BY NMR OF 176-286.
RG RIKEN structural genomics initiative (RSGI);
RT "Solution structure of the CS domain of human KIAA1068.";
RL Submitted (NOV-2004) to the PDB data bank.
CC -!- INTERACTION:
CC Q8IVD9; Q9H2C0: GAN; NbExp=2; IntAct=EBI-744342, EBI-764342;
CC Q8IVD9; Q9Y5Z7: HCFC2; NbExp=2; IntAct=EBI-744342, EBI-592728;
CC Q8IVD9; Q6PID8: KLHDC10; NbExp=2; IntAct=EBI-744342, EBI-3201175;
CC Q8IVD9; Q9Y2U9: KLHDC2; NbExp=2; IntAct=EBI-744342, EBI-715326;
CC Q8IVD9; Q8IYD2: KLHDC8A; NbExp=2; IntAct=EBI-744342, EBI-9477915;
CC Q8IVD9; Q53GT1: KLHL22; NbExp=2; IntAct=EBI-744342, EBI-1996072;
CC Q8IVD9; Q8NBE8: KLHL23; NbExp=2; IntAct=EBI-744342, EBI-2512246;
CC Q8IVD9; Q96CT2: KLHL29; NbExp=2; IntAct=EBI-744342, EBI-6426370;
CC Q8IVD9; Q2WGJ6: KLHL38; NbExp=2; IntAct=EBI-744342, EBI-6426443;
CC Q8IVD9; Q8WZ60: KLHL6; NbExp=2; IntAct=EBI-744342, EBI-6426464;
CC Q8IVD9; P43034: PAFAH1B1; NbExp=2; IntAct=EBI-744342, EBI-720620;
CC Q8IVD9; Q6NSI4: RADX; NbExp=2; IntAct=EBI-744342, EBI-8634209;
CC Q8IVD9; Q15393: SF3B3; NbExp=2; IntAct=EBI-744342, EBI-346977;
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH03691.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=AAQ96892.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=BAB14855.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AC004453; AAQ96892.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC003691; AAH03691.1; ALT_INIT; mRNA.
DR EMBL; BC011673; AAH11673.2; -; mRNA.
DR EMBL; BC035014; AAH35014.1; -; mRNA.
DR EMBL; AB028991; BAA83020.1; -; mRNA.
DR EMBL; AK024226; BAB14855.1; ALT_INIT; mRNA.
DR CCDS; CCDS5490.2; -.
DR RefSeq; NP_056147.2; NM_015332.3.
DR PDB; 1WGV; NMR; -; A=176-286.
DR PDBsum; 1WGV; -.
DR AlphaFoldDB; Q8IVD9; -.
DR BMRB; Q8IVD9; -.
DR SMR; Q8IVD9; -.
DR BioGRID; 116962; 128.
DR CORUM; Q8IVD9; -.
DR DIP; DIP-53643N; -.
DR IntAct; Q8IVD9; 141.
DR MINT; Q8IVD9; -.
DR STRING; 9606.ENSP00000347626; -.
DR GlyGen; Q8IVD9; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q8IVD9; -.
DR MetOSite; Q8IVD9; -.
DR PhosphoSitePlus; Q8IVD9; -.
DR BioMuta; NUDCD3; -.
DR DMDM; 145559509; -.
DR EPD; Q8IVD9; -.
DR jPOST; Q8IVD9; -.
DR MassIVE; Q8IVD9; -.
DR MaxQB; Q8IVD9; -.
DR PaxDb; Q8IVD9; -.
DR PeptideAtlas; Q8IVD9; -.
DR PRIDE; Q8IVD9; -.
DR ProteomicsDB; 70681; -.
DR Antibodypedia; 13393; 104 antibodies from 24 providers.
DR DNASU; 23386; -.
DR Ensembl; ENST00000355451.8; ENSP00000347626.6; ENSG00000015676.18.
DR GeneID; 23386; -.
DR KEGG; hsa:23386; -.
DR MANE-Select; ENST00000355451.8; ENSP00000347626.6; NM_015332.4; NP_056147.2.
DR UCSC; uc003tkz.4; human.
DR CTD; 23386; -.
DR DisGeNET; 23386; -.
DR GeneCards; NUDCD3; -.
DR HGNC; HGNC:22208; NUDCD3.
DR HPA; ENSG00000015676; Low tissue specificity.
DR MIM; 610296; gene.
DR neXtProt; NX_Q8IVD9; -.
DR OpenTargets; ENSG00000015676; -.
DR PharmGKB; PA134989375; -.
DR VEuPathDB; HostDB:ENSG00000015676; -.
DR eggNOG; KOG2265; Eukaryota.
DR GeneTree; ENSGT00940000158444; -.
DR HOGENOM; CLU_047332_0_0_1; -.
DR InParanoid; Q8IVD9; -.
DR OMA; RNTDFYH; -.
DR OrthoDB; 1489576at2759; -.
DR PhylomeDB; Q8IVD9; -.
DR TreeFam; TF300147; -.
DR PathwayCommons; Q8IVD9; -.
DR SignaLink; Q8IVD9; -.
DR BioGRID-ORCS; 23386; 387 hits in 1080 CRISPR screens.
DR ChiTaRS; NUDCD3; human.
DR EvolutionaryTrace; Q8IVD9; -.
DR GeneWiki; NUDCD3_(gene); -.
DR GenomeRNAi; 23386; -.
DR Pharos; Q8IVD9; Tbio.
DR PRO; PR:Q8IVD9; -.
DR Proteomes; UP000005640; Chromosome 7.
DR RNAct; Q8IVD9; protein.
DR Bgee; ENSG00000015676; Expressed in cortical plate and 199 other tissues.
DR Genevisible; Q8IVD9; HS.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005868; C:cytoplasmic dynein complex; IDA:GO_Central.
DR GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR GO; GO:0060271; P:cilium assembly; IMP:GO_Central.
DR GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR GO; GO:1905793; P:protein localization to pericentriolar material; IMP:GO_Central.
DR CDD; cd06495; p23_NUDCD3_like; 1.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR037898; NudC_fam.
DR InterPro; IPR025934; NudC_N_dom.
DR InterPro; IPR027761; NUDCD3.
DR InterPro; IPR037905; p23_NUDCD3.
DR PANTHER; PTHR12356; PTHR12356; 1.
DR PANTHER; PTHR12356:SF19; PTHR12356:SF19; 1.
DR Pfam; PF04969; CS; 1.
DR Pfam; PF14050; Nudc_N; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS51203; CS; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Phosphoprotein; Reference proteome.
FT CHAIN 1..361
FT /note="NudC domain-containing protein 3"
FT /id="PRO_0000057985"
FT DOMAIN 185..277
FT /note="CS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT REGION 87..106
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 124..158
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..101
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 146
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:17525332"
FT MOD_RES 340
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:23186163"
FT MOD_RES 355
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:19690332,
FT ECO:0007744|PubMed:20068231"
FT VARIANT 3
FT /note="T -> P (in dbSNP:rs307007)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_054036"
FT VARIANT 235
FT /note="R -> C (in dbSNP:rs11550029)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_031709"
FT CONFLICT 205
FT /note="V -> L (in Ref. 2; AAH35014)"
FT /evidence="ECO:0000305"
FT STRAND 179..185
FT /evidence="ECO:0007829|PDB:1WGV"
FT STRAND 191..195
FT /evidence="ECO:0007829|PDB:1WGV"
FT STRAND 198..204
FT /evidence="ECO:0007829|PDB:1WGV"
FT HELIX 212..214
FT /evidence="ECO:0007829|PDB:1WGV"
FT STRAND 215..219
FT /evidence="ECO:0007829|PDB:1WGV"
FT STRAND 221..229
FT /evidence="ECO:0007829|PDB:1WGV"
FT STRAND 231..244
FT /evidence="ECO:0007829|PDB:1WGV"
FT TURN 248..250
FT /evidence="ECO:0007829|PDB:1WGV"
FT STRAND 252..255
FT /evidence="ECO:0007829|PDB:1WGV"
FT STRAND 259..265
FT /evidence="ECO:0007829|PDB:1WGV"
FT STRAND 267..270
FT /evidence="ECO:0007829|PDB:1WGV"
SQ SEQUENCE 361 AA; 40822 MW; 06B54758C395818A CRC64;
METGAAELYD QALLGILQHV GNVQDFLRVL FGFLYRKTDF YRLLRHPSDR MGFPPGAAQA
LVLQVFKTFD HMARQDDEKR RQELEEKIRR KEEEEAKTVS AAAAEKEPVP VPVQEIEIDS
TTELDGHQEV EKVQPPGPVK EMAHGSQEAE APGAVAGAAE VPREPPILPR IQEQFQKNPD
SYNGAVRENY TWSQDYTDLE VRVPVPKHVV KGKQVSVALS SSSIRVAMLE ENGERVLMEG
KLTHKINTES SLWSLEPGKC VLVNLSKVGE YWWNAILEGE EPIDIDKINK ERSMATVDEE
EQAVLDRLTF DYHQKLQGKP QSHELKVHEM LKKGWDAEGS PFRGQRFDPA MFNISPGAVQ
F
