ID   NUDC2_RAT               Reviewed;         157 AA.
AC   Q5M823;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   03-AUG-2022, entry version 103.
DE   RecName: Full=NudC domain-containing protein 2;
GN   Name=Nudcd2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May regulate the LIS1/dynein pathway by stabilizing LIS1 with
CC       Hsp90 chaperone. {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with LIS1. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC       {ECO:0000250}. Cytoplasm, cytoskeleton, microtubule organizing center,
CC       centrosome {ECO:0000250}. Cytoplasm, cytoskeleton, spindle pole
CC       {ECO:0000250}. Note=Associates with centrosomes in interphase and to
CC       spindle poles and kinetochores during mitosis. {ECO:0000250}.
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DR   EMBL; BC088299; AAH88299.1; -; mRNA.
DR   RefSeq; NP_001009621.1; NM_001009621.2.
DR   AlphaFoldDB; Q5M823; -.
DR   SMR; Q5M823; -.
DR   STRING; 10116.ENSRNOP00000004339; -.
DR   jPOST; Q5M823; -.
DR   PRIDE; Q5M823; -.
DR   Ensembl; ENSRNOT00000111631; ENSRNOP00000077894; ENSRNOG00000060914.
DR   GeneID; 287199; -.
DR   KEGG; rno:287199; -.
DR   UCSC; RGD:1307203; rat.
DR   CTD; 134492; -.
DR   RGD; 1307203; Nudcd2.
DR   eggNOG; KOG2265; Eukaryota.
DR   GeneTree; ENSGT00390000001644; -.
DR   HOGENOM; CLU_113495_1_0_1; -.
DR   InParanoid; Q5M823; -.
DR   OMA; DPRSFMG; -.
DR   OrthoDB; 1310591at2759; -.
DR   PhylomeDB; Q5M823; -.
DR   TreeFam; TF332391; -.
DR   PRO; PR:Q5M823; -.
DR   Proteomes; UP000002494; Chromosome 10.
DR   Bgee; ENSRNOG00000060914; Expressed in thymus and 19 other tissues.
DR   Genevisible; Q5M823; RN.
DR   GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR   GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR   GO; GO:0045171; C:intercellular bridge; IEA:Ensembl.
DR   GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR   GO; GO:0005815; C:microtubule organizing center; IEA:UniProtKB-SubCell.
DR   GO; GO:0072686; C:mitotic spindle; IEA:Ensembl.
DR   GO; GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
DR   GO; GO:0051082; F:unfolded protein binding; IBA:GO_Central.
DR   GO; GO:0006457; P:protein folding; IBA:GO_Central.
DR   CDD; cd06494; p23_NUDCD2_like; 1.
DR   Gene3D; 2.60.40.790; -; 1.
DR   InterPro; IPR007052; CS_dom.
DR   InterPro; IPR008978; HSP20-like_chaperone.
DR   InterPro; IPR037898; NudC_fam.
DR   InterPro; IPR037902; p23_NUDCD2.
DR   PANTHER; PTHR12356; PTHR12356; 1.
DR   Pfam; PF04969; CS; 1.
DR   SUPFAM; SSF49764; SSF49764; 1.
DR   PROSITE; PS51203; CS; 1.
PE   2: Evidence at transcript level;
KW   Acetylation; Centromere; Chromosome; Cytoplasm; Cytoskeleton; Kinetochore;
KW   Phosphoprotein; Reference proteome.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WVJ2"
FT   CHAIN           2..157
FT                   /note="NudC domain-containing protein 2"
FT                   /id="PRO_0000057984"
FT   DOMAIN          14..104
FT                   /note="CS"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT   REGION          134..157
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         2
FT                   /note="N-acetylserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WVJ2"
FT   MOD_RES         142
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000250|UniProtKB:Q8WVJ2"
FT   MOD_RES         145
FT                   /note="Phosphotyrosine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9CQ48"
SQ   SEQUENCE   157 AA;  17674 MW;  F52FA5C953521B46 CRC64;
     MSAPFEERSG VVPCATPWGQ WYQTLEEVFI EVQVPPGTRA QDIQCGLQSR HVALAVGGRE
     ILKGKLFDST IADEGTWTLE DRKMVRIVLT KTKRDAANCW TSLLESEYAA DPWVQDQMQR
     KLTLERFQKE NPGFDFSGAE ISGNYTKGGP DFSNLEK