NUDC1_MOUSE
ID NUDC1_MOUSE Reviewed; 582 AA.
AC Q6PIP5; Q3THV3; Q71EC1; Q8BJZ5;
DT 23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 23-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 110.
DE RecName: Full=NudC domain-containing protein 1;
GN Name=Nudcd1 {ECO:0000312|MGI:MGI:1914679};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAQ08822.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:AAQ08822.1};
RX PubMed=14688378; DOI=10.4049/jimmunol.172.1.651;
RA Yan Y., Phan L., Yang F., Talpaz M., Yang Y., Xiong Z., Ng B.,
RA Timchenko N.A., Wu C.J., Ritz J., Wang H., Yang X.-F.;
RT "A novel mechanism of alternative promoter and splicing regulates the
RT epitope generation of tumor antigen CML66-L.";
RL J. Immunol. 172:651-660(2004).
RN [2] {ECO:0000312|EMBL:BAE39873.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J {ECO:0000312|EMBL:BAC36947.1}, and
RC DBA/2J {ECO:0000312|EMBL:BAE39873.1};
RC TISSUE=Embryo {ECO:0000312|EMBL:BAC36947.1};
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3] {ECO:0000312|EMBL:AAH31583.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N {ECO:0000312|EMBL:AAH31583.1};
RC TISSUE=Mammary tumor {ECO:0000312|EMBL:AAH31583.1};
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Lung, Pancreas, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
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DR EMBL; AF521132; AAQ08822.1; -; mRNA.
DR EMBL; AK077673; BAC36947.1; -; mRNA.
DR EMBL; AK167855; BAE39873.1; -; mRNA.
DR EMBL; AK168122; BAE40093.1; -; mRNA.
DR EMBL; BC031583; AAH31583.1; -; mRNA.
DR CCDS; CCDS27455.1; -.
DR RefSeq; NP_001107026.1; NM_001113554.1.
DR RefSeq; NP_080425.3; NM_026149.4.
DR AlphaFoldDB; Q6PIP5; -.
DR SMR; Q6PIP5; -.
DR BioGRID; 212180; 12.
DR STRING; 10090.ENSMUSP00000042746; -.
DR iPTMnet; Q6PIP5; -.
DR PhosphoSitePlus; Q6PIP5; -.
DR EPD; Q6PIP5; -.
DR MaxQB; Q6PIP5; -.
DR PaxDb; Q6PIP5; -.
DR PeptideAtlas; Q6PIP5; -.
DR PRIDE; Q6PIP5; -.
DR ProteomicsDB; 293812; -.
DR Antibodypedia; 13450; 115 antibodies from 20 providers.
DR DNASU; 67429; -.
DR Ensembl; ENSMUST00000227843; ENSMUSP00000154478; ENSMUSG00000038736.
DR GeneID; 67429; -.
DR KEGG; mmu:67429; -.
DR UCSC; uc007vpq.2; mouse.
DR CTD; 84955; -.
DR MGI; MGI:1914679; Nudcd1.
DR VEuPathDB; HostDB:ENSMUSG00000038736; -.
DR eggNOG; KOG4379; Eukaryota.
DR GeneTree; ENSGT00390000007776; -.
DR HOGENOM; CLU_021010_1_0_1; -.
DR InParanoid; Q6PIP5; -.
DR OMA; ANFDGYK; -.
DR OrthoDB; 1139120at2759; -.
DR PhylomeDB; Q6PIP5; -.
DR TreeFam; TF323350; -.
DR BioGRID-ORCS; 67429; 6 hits in 76 CRISPR screens.
DR ChiTaRS; Nudcd1; mouse.
DR PRO; PR:Q6PIP5; -.
DR Proteomes; UP000000589; Chromosome 15.
DR RNAct; Q6PIP5; protein.
DR Bgee; ENSMUSG00000038736; Expressed in primitive streak and 235 other tissues.
DR ExpressionAtlas; Q6PIP5; baseline and differential.
DR Genevisible; Q6PIP5; MM.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR Gene3D; 2.60.40.790; -; 1.
DR InterPro; IPR007052; CS_dom.
DR InterPro; IPR008978; HSP20-like_chaperone.
DR InterPro; IPR037895; NUDCD1.
DR PANTHER; PTHR21664; PTHR21664; 1.
DR Pfam; PF04969; CS; 1.
DR SUPFAM; SSF49764; SSF49764; 1.
DR PROSITE; PS51203; CS; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; Nucleus; Phosphoprotein; Reference proteome.
FT CHAIN 1..582
FT /note="NudC domain-containing protein 1"
FT /id="PRO_0000307705"
FT DOMAIN 272..360
FT /note="CS"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00547"
FT MOD_RES 7
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96RS6"
FT MOD_RES 387
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q96RS6"
FT CONFLICT 22
FT /note="Y -> C (in Ref. 2; BAE39873/BAE40093)"
FT /evidence="ECO:0000305"
FT CONFLICT 26..28
FT /note="LEP -> FER (in Ref. 2; BAE39873/BAE40093)"
FT /evidence="ECO:0000305"
FT CONFLICT 49
FT /note="Q -> K (in Ref. 1; AAQ08822)"
FT /evidence="ECO:0000305"
FT CONFLICT 113
FT /note="R -> L (in Ref. 2; BAC36947)"
FT /evidence="ECO:0000305"
FT CONFLICT 180
FT /note="I -> V (in Ref. 1; AAQ08822)"
FT /evidence="ECO:0000305"
FT CONFLICT 257
FT /note="Q -> K (in Ref. 2; BAC36947)"
FT /evidence="ECO:0000305"
FT CONFLICT 273
FT /note="Missing (in Ref. 1; AAQ08822)"
FT /evidence="ECO:0000305"
FT CONFLICT 302
FT /note="Q -> R (in Ref. 3; AAH31583)"
FT /evidence="ECO:0000305"
FT CONFLICT 428
FT /note="Q -> K (in Ref. 3; AAH31583)"
FT /evidence="ECO:0000305"
FT CONFLICT 441
FT /note="L -> M (in Ref. 2; BAE39873/BAE40093)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 582 AA; 66705 MW; B62BB34C1F9F1A64 CRC64;
MEAANCSLRV KRPLLDPRFE GYKLSLEPLP CYQLELDAAV AEVKLRDDQY TLEHMHAFGM
YNYLHCDAWY QDSVYYIDNL GRIMNLTVML DTALGKPREV FRLPTDVTAY DNRLCASIHF
TSPSWVTLSD GTGRLYVIGT GDRGNSPEKW EIMFNEELGN PFIIIHSISL LKAEEHSVAI
LLLRIEKEEL DLKGSGFYVS LEWVVVTKKK EDSKKYEITK HHVLRGKSVP HYAAIEPNGN
GLMIVSYKSF KVISGDQDLE ENMDEDRPEK IKVEPLYYWQ QSEDDLTVTV RLPESSTKED
IQIQFLPDNI NIKLKDIQVL EGKLYSSIDH EGSTWTIKEN DSLEISLIKK NEGLMWPELV
VGDKQGELLR DPAQCAAIAE RLMHLTSDEL NPNPDKEKPA CNAQELEECD IFFEESSSLC
RFDGNTLQTT HVVNLGSNQY LFSVIVDPKE MPCFCLRHDV DALLWQPHCS KQDDMWEHIA
TFNALGYVQA SKRDKKFFAC APNYSYAALC ECLRRVFIYR QPTPMSTVLY NRKEGRHVGQ
VAKQQVASLE TNDPILGFQA TNERLFVLTT KNLFLIRVNT EN
