ID   NU3M_PERMA              Reviewed;         115 AA.
AC   Q95891; Q95894; Q95900; Q95902; Q95904;
DT   15-JUL-1998, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1998, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=NADH-ubiquinone oxidoreductase chain 3 {ECO:0000250|UniProtKB:P03897};
DE            EC=7.1.1.2 {ECO:0000250|UniProtKB:P03897};
DE   AltName: Full=NADH dehydrogenase subunit 3;
GN   Name=MT-ND3 {ECO:0000250|UniProtKB:P03897}; Synonyms=MTND3, NADH3, ND3;
OS   Peromyscus maniculatus (North American deer mouse).
OG   Mitochondrion.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea;
OC   Cricetidae; Neotominae; Peromyscus.
OX   NCBI_TaxID=10042;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Austericus, Coolidgei, Interdictus, Oreas, and Rufinus;
RA   Hogan K.M., Davis S.K., Greenbaum I.F.;
RL   Submitted (NOV-1995) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC       NADH dehydrogenase (Complex I) which catalyzes electron transfer from
CC       NADH through the respiratory chain, using ubiquinone as an electron
CC       acceptor. Essential for the catalytic activity of complex I.
CC       {ECO:0000250|UniProtKB:P03897}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC         NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC         COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC         ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC         Evidence={ECO:0000250|UniProtKB:P03897};
CC   -!- SUBUNIT: Core subunit of respiratory chain NADH dehydrogenase (Complex
CC       I) which is composed of 45 different subunits. Interacts with TMEM186.
CC       Interacts with TMEM242 (By similarity). {ECO:0000250|UniProtKB:P03897}.
CC   -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane
CC       {ECO:0000250|UniProtKB:P03898}; Multi-pass membrane protein
CC       {ECO:0000255}.
CC   -!- SIMILARITY: Belongs to the complex I subunit 3 family. {ECO:0000305}.
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DR   EMBL; U40062; AAB17909.1; -; Genomic_DNA.
DR   EMBL; U40063; AAB17912.1; -; Genomic_DNA.
DR   EMBL; U40249; AAB17924.1; -; Genomic_DNA.
DR   EMBL; U40250; AAB17927.1; -; Genomic_DNA.
DR   EMBL; U40251; AAB17930.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q95891; -.
DR   SMR; Q95891; -.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005743; C:mitochondrial inner membrane; ISS:UniProtKB.
DR   GO; GO:0070469; C:respirasome; IEA:UniProtKB-KW.
DR   GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; ISS:UniProtKB.
DR   GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; ISS:UniProtKB.
DR   Gene3D; 1.20.58.1610; -; 1.
DR   InterPro; IPR000440; NADH_UbQ/plastoQ_OxRdtase_su3.
DR   InterPro; IPR038430; NDAH_ubi_oxred_su3_sf.
DR   PANTHER; PTHR11058; PTHR11058; 1.
DR   Pfam; PF00507; Oxidored_q4; 1.
PE   3: Inferred from homology;
KW   Electron transport; Membrane; Mitochondrion; Mitochondrion inner membrane;
KW   NAD; Respiratory chain; Translocase; Transmembrane; Transmembrane helix;
KW   Transport; Ubiquinone.
FT   CHAIN           1..115
FT                   /note="NADH-ubiquinone oxidoreductase chain 3"
FT                   /id="PRO_0000117796"
FT   TRANSMEM        4..24
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        55..75
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        84..104
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   VARIANT         15
FT                   /note="M -> T (in strain: Coolidgei)"
FT   VARIANT         20
FT                   /note="V -> I (in strain: Austericus and Rufinus)"
FT   VARIANT         42
FT                   /note="D -> E (in strain: Rufinus)"
FT   VARIANT         56
FT                   /note="F -> L (in strain: Oreas)"
FT   VARIANT         84
FT                   /note="I -> T (in strain: Coolidgei)"
FT   VARIANT         85
FT                   /note="D -> N (in strain: Austericus, Coolidgei and
FT                   Rufinus)"
FT   VARIANT         104
FT                   /note="Y -> H (in strain: Rufinus)"
SQ   SEQUENCE   115 AA;  13181 MW;  61B275469729EBB5 CRC64;
     MNMLTALLVN ITLSMLLIIV AFWLPQLNLY TEKANPYECG FDPMGSARLP FSMKFFLVAI
     TFLLFDLEIA LLLPLPWAIQ MYNIDIMMLT AFILVSVLAL GLAYEWLQKG LEWTE