NU1M_SHEEP
ID NU1M_SHEEP Reviewed; 318 AA.
AC O78747;
DT 15-DEC-1998, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 95.
DE RecName: Full=NADH-ubiquinone oxidoreductase chain 1;
DE EC=7.1.1.2;
DE AltName: Full=NADH dehydrogenase subunit 1;
GN Name=MT-ND1; Synonyms=MTND1, NADH1, ND1;
OS Ovis aries (Sheep).
OG Mitochondrion.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Caprinae; Ovis.
OX NCBI_TaxID=9940;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Merinolandschaf {ECO:0000312|Proteomes:UP000002356}; TISSUE=Liver;
RX PubMed=9767689; DOI=10.1007/pl00006401;
RA Hiendleder S., Lewalski H., Wassmuth R., Janke A.;
RT "The complete mitochondrial DNA sequence of the domestic sheep (Ovis aries)
RT and comparison with the other major ovine haplotype.";
RL J. Mol. Evol. 47:441-448(1998).
CC -!- FUNCTION: Core subunit of the mitochondrial membrane respiratory chain
CC NADH dehydrogenase (Complex I) that is believed to belong to the
CC minimal assembly required for catalysis. Complex I functions in the
CC transfer of electrons from NADH to the respiratory chain. The immediate
CC electron acceptor for the enzyme is believed to be ubiquinone (By
CC similarity). {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a ubiquinone + 5 H(+)(in) + NADH = a ubiquinol + 4 H(+)(out) +
CC NAD(+); Xref=Rhea:RHEA:29091, Rhea:RHEA-COMP:9565, Rhea:RHEA-
CC COMP:9566, ChEBI:CHEBI:15378, ChEBI:CHEBI:16389, ChEBI:CHEBI:17976,
CC ChEBI:CHEBI:57540, ChEBI:CHEBI:57945; EC=7.1.1.2;
CC -!- SUBCELLULAR LOCATION: Mitochondrion inner membrane {ECO:0000250};
CC Multi-pass membrane protein {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the complex I subunit 1 family. {ECO:0000305}.
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DR EMBL; AF010406; AAD10096.1; -; Genomic_DNA.
DR PIR; T11050; T11050.
DR RefSeq; NP_008406.1; NC_001941.1.
DR PDB; 5LNK; EM; 3.90 A; H=1-318.
DR PDB; 6Q9B; EM; 3.90 A; D1=1-318.
DR PDB; 6QA9; EM; 4.10 A; D1=1-318.
DR PDB; 6QBX; EM; 4.20 A; D1=1-318.
DR PDB; 6QC2; EM; 4.20 A; D1=1-318.
DR PDB; 6QC3; EM; 4.20 A; D1=1-318.
DR PDB; 6QC4; EM; 4.60 A; D1=1-318.
DR PDB; 6QC5; EM; 4.30 A; D1=1-318.
DR PDB; 6QC6; EM; 4.10 A; D1=1-318.
DR PDB; 6QC7; EM; 4.40 A; D1=1-318.
DR PDB; 6QC8; EM; 4.20 A; D1=1-318.
DR PDB; 6QC9; EM; 5.70 A; D1=1-318.
DR PDB; 6QCA; EM; 6.20 A; D1=1-318.
DR PDB; 6QCF; EM; 6.50 A; D1=1-318.
DR PDB; 6ZKA; EM; 2.50 A; H=1-318.
DR PDB; 6ZKB; EM; 2.90 A; H=1-318.
DR PDB; 6ZKC; EM; 3.10 A; H=1-318.
DR PDB; 6ZKD; EM; 2.70 A; H=1-318.
DR PDB; 6ZKE; EM; 2.60 A; H=1-318.
DR PDB; 6ZKF; EM; 2.80 A; H=1-318.
DR PDB; 6ZKG; EM; 3.40 A; H=1-318.
DR PDB; 6ZKH; EM; 3.00 A; H=1-318.
DR PDB; 6ZKI; EM; 2.80 A; H=1-318.
DR PDB; 6ZKJ; EM; 3.00 A; H=1-318.
DR PDB; 6ZKK; EM; 3.70 A; H=1-318.
DR PDB; 6ZKL; EM; 3.10 A; H=1-318.
DR PDB; 6ZKM; EM; 2.80 A; H=1-318.
DR PDB; 6ZKN; EM; 2.90 A; H=1-318.
DR PDB; 6ZKO; EM; 3.80 A; H=1-318.
DR PDB; 6ZKP; EM; 3.20 A; H=1-318.
DR PDB; 6ZKQ; EM; 3.30 A; H=1-318.
DR PDB; 6ZKR; EM; 3.50 A; H=1-318.
DR PDB; 6ZKS; EM; 3.10 A; H=1-318.
DR PDB; 6ZKT; EM; 2.80 A; H=1-318.
DR PDB; 6ZKU; EM; 3.00 A; H=1-318.
DR PDB; 6ZKV; EM; 2.90 A; H=1-318.
DR PDBsum; 5LNK; -.
DR PDBsum; 6Q9B; -.
DR PDBsum; 6QA9; -.
DR PDBsum; 6QBX; -.
DR PDBsum; 6QC2; -.
DR PDBsum; 6QC3; -.
DR PDBsum; 6QC4; -.
DR PDBsum; 6QC5; -.
DR PDBsum; 6QC6; -.
DR PDBsum; 6QC7; -.
DR PDBsum; 6QC8; -.
DR PDBsum; 6QC9; -.
DR PDBsum; 6QCA; -.
DR PDBsum; 6QCF; -.
DR PDBsum; 6ZKA; -.
DR PDBsum; 6ZKB; -.
DR PDBsum; 6ZKC; -.
DR PDBsum; 6ZKD; -.
DR PDBsum; 6ZKE; -.
DR PDBsum; 6ZKF; -.
DR PDBsum; 6ZKG; -.
DR PDBsum; 6ZKH; -.
DR PDBsum; 6ZKI; -.
DR PDBsum; 6ZKJ; -.
DR PDBsum; 6ZKK; -.
DR PDBsum; 6ZKL; -.
DR PDBsum; 6ZKM; -.
DR PDBsum; 6ZKN; -.
DR PDBsum; 6ZKO; -.
DR PDBsum; 6ZKP; -.
DR PDBsum; 6ZKQ; -.
DR PDBsum; 6ZKR; -.
DR PDBsum; 6ZKS; -.
DR PDBsum; 6ZKT; -.
DR PDBsum; 6ZKU; -.
DR PDBsum; 6ZKV; -.
DR AlphaFoldDB; O78747; -.
DR SMR; O78747; -.
DR STRING; 9940.ENSOARP00000000001; -.
DR Ensembl; ENSOART00000000006; ENSOARP00000000001; ENSOARG00000000006.
DR Ensembl; ENSOART00020000007; ENSOARP00020000002; ENSOARG00020000007.
DR GeneID; 808249; -.
DR KEGG; oas:808249; -.
DR CTD; 4535; -.
DR eggNOG; KOG4770; Eukaryota.
DR HOGENOM; CLU_015134_0_1_1; -.
DR OMA; WSGWASN; -.
DR OrthoDB; 1214989at2759; -.
DR Proteomes; UP000002356; Mitochondrion.
DR Bgee; ENSOARG00000000006; Expressed in cerebellum and 55 other tissues.
DR ExpressionAtlas; O78747; baseline.
DR GO; GO:0005747; C:mitochondrial respiratory chain complex I; IEA:Ensembl.
DR GO; GO:0008137; F:NADH dehydrogenase (ubiquinone) activity; IEA:UniProtKB-EC.
DR GO; GO:0006120; P:mitochondrial electron transport, NADH to ubiquinone; IEA:Ensembl.
DR GO; GO:0032981; P:mitochondrial respiratory chain complex I assembly; IEA:Ensembl.
DR HAMAP; MF_01350; NDH1_NuoH; 1.
DR InterPro; IPR001694; NADH_UbQ_OxRdtase_su1/FPO.
DR InterPro; IPR018086; NADH_UbQ_OxRdtase_su1_CS.
DR PANTHER; PTHR11432; PTHR11432; 1.
DR Pfam; PF00146; NADHdh; 1.
DR PROSITE; PS00667; COMPLEX1_ND1_1; 1.
DR PROSITE; PS00668; COMPLEX1_ND1_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Electron transport; Membrane; Mitochondrion;
KW Mitochondrion inner membrane; NAD; Reference proteome; Respiratory chain;
KW Translocase; Transmembrane; Transmembrane helix; Transport; Ubiquinone.
FT CHAIN 1..318
FT /note="NADH-ubiquinone oxidoreductase chain 1"
FT /id="PRO_0000117476"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 68..88
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 100..120
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 147..167
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 217..237
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 294..314
FT /note="Helical"
FT /evidence="ECO:0000255"
FT HELIX 2..30
FT /evidence="ECO:0007829|PDB:6ZKA"
FT TURN 31..33
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 39..41
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 42..44
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 47..56
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 64..66
FT /evidence="ECO:0007829|PDB:6ZKB"
FT HELIX 68..84
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 86..88
FT /evidence="ECO:0007829|PDB:6ZKV"
FT STRAND 91..93
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 101..110
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 113..122
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 126..154
FT /evidence="ECO:0007829|PDB:6ZKA"
FT TURN 155..157
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 158..160
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 164..168
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 170..172
FT /evidence="ECO:0007829|PDB:6ZKA"
FT TURN 174..178
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 179..192
FT /evidence="ECO:0007829|PDB:6ZKA"
FT STRAND 201..205
FT /evidence="ECO:0007829|PDB:6ZKI"
FT STRAND 207..209
FT /evidence="ECO:0007829|PDB:6ZKB"
FT STRAND 210..212
FT /evidence="ECO:0007829|PDB:6ZKI"
FT HELIX 217..242
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 253..274
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 282..290
FT /evidence="ECO:0007829|PDB:6ZKA"
FT HELIX 293..310
FT /evidence="ECO:0007829|PDB:6ZKA"
SQ SEQUENCE 318 AA; 35867 MW; 385BC8C6EDF26959 CRC64;
MFMINVLTLI IPILLAVAFL TLVERKVLGY MQFRKGPNVV GPYGLLQPIA DAIKLFIKEP
LRPATSSISM FILAPILALT LALTMWIPLP MPYPLINMNL GVLFMLAMSS LAVYSILWSG
WASNSKYALI GALRAVAQTI SYEVTLAIIL LSVLLMNGSF TLSTLIITQE QVWLIFPAWP
LAMMWFISTL AETNRAPFDL TEGESELVSG FNVEYAAGPF ALFFMAEYAN IIMMNIFTTT
LFLGAFHNPY MPELYTINFT IKSLLLSITF LWIRASYPRF RYDQLMHLLW KNFLPLTLAL
CMWHVSLPIL LSSIPPQT
