ID   NPY_ICTPU               Reviewed;          95 AA.
AC   Q9I9D3;
DT   26-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Pro-neuropeptide Y;
DE   Contains:
DE     RecName: Full=Neuropeptide Y;
DE     AltName: Full=Neuropeptide tyrosine;
DE              Short=NPY;
DE   Contains:
DE     RecName: Full=C-flanking peptide of NPY;
DE              Short=CPON;
DE   Flags: Precursor;
GN   Name=npy;
OS   Ictalurus punctatus (Channel catfish) (Silurus punctatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Siluriformes;
OC   Ictaluridae; Ictalurus.
OX   NCBI_TaxID=7998;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RA   Leonard J.B.K., Waldbieser G.C., Silverstein J.T.;
RT   "Neuropeptide Y (NPY) sequence and distribution in channel catfish
RT   (Ictalurus punctatus).";
RL   Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: NPY is implicated in the control of feeding and in secretion
CC       of gonadotrophin-release hormone.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NPY family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF267164; AAF71617.1; -; mRNA.
DR   RefSeq; NP_001187016.1; NM_001200087.1.
DR   AlphaFoldDB; Q9I9D3; -.
DR   STRING; 7998.ENSIPUP00000009019; -.
DR   GeneID; 100304501; -.
DR   KEGG; ipu:100304501; -.
DR   CTD; 4852; -.
DR   OrthoDB; 1542445at2759; -.
DR   Proteomes; UP000221080; Chromosome 12.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005179; F:hormone activity; IEA:InterPro.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
DR   CDD; cd00126; PAH; 1.
DR   InterPro; IPR001955; Pancreatic_hormone-like.
DR   InterPro; IPR020392; Pancreatic_hormone-like_CS.
DR   PANTHER; PTHR10533; PTHR10533; 1.
DR   Pfam; PF00159; Hormone_3; 1.
DR   PRINTS; PR00278; PANCHORMONE.
DR   SMART; SM00309; PAH; 1.
DR   PROSITE; PS00265; PANCREATIC_HORMONE_1; 1.
DR   PROSITE; PS50276; PANCREATIC_HORMONE_2; 1.
PE   3: Inferred from homology;
KW   Amidation; Cleavage on pair of basic residues; Neuropeptide; Secreted;
KW   Signal.
FT   SIGNAL          1..27
FT                   /evidence="ECO:0000250"
FT   PEPTIDE         28..63
FT                   /note="Neuropeptide Y"
FT                   /id="PRO_0000025343"
FT   PEPTIDE         67..95
FT                   /note="C-flanking peptide of NPY"
FT                   /id="PRO_0000025344"
FT   MOD_RES         63
FT                   /note="Tyrosine amide"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   95 AA;  10729 MW;  9AE19EAFBE24C6B5 CRC64;
     MRPRANVCVG WAACILLVVC LCVLAEGYPT KPENPGEDAP VEELAKYYSA LRHYINLITR
     QRYGKRSNTD VLTPDLLFGE AEIRLQSRYD DPLMG