ID   NPRL3_CAEEL             Reviewed;         511 AA.
AC   Q20069;
DT   26-SEP-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 107.
DE   RecName: Full=GATOR complex protein NPRL3 {ECO:0000305};
DE   AltName: Full=Nitrogen permease regulator 3-like protein;
GN   Name=nprl-3; ORFNames=F35H10.7;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: As a component of the GATOR complex may function in the amino
CC       acid-sensing branch of the TORC1 signaling pathway.
CC       {ECO:0000250|UniProtKB:Q12980}.
CC   -!- SUBUNIT: Probably part of the GATOR complex.
CC       {ECO:0000250|UniProtKB:Q12980}.
CC   -!- SUBCELLULAR LOCATION: Lysosome membrane {ECO:0000250|UniProtKB:Q12980}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; FO081169; CCD69640.1; -; Genomic_DNA.
DR   PIR; T16279; T16279.
DR   RefSeq; NP_501396.1; NM_068995.6.
DR   AlphaFoldDB; Q20069; -.
DR   BioGRID; 50106; 1.
DR   STRING; 6239.F35H10.7.2; -.
DR   PaxDb; Q20069; -.
DR   PeptideAtlas; Q20069; -.
DR   PRIDE; Q20069; -.
DR   EnsemblMetazoa; F35H10.7a.1; F35H10.7a.1; WBGene00018072.
DR   GeneID; 185331; -.
DR   KEGG; cel:CELE_F35H10.7; -.
DR   UCSC; F35H10.7.1; c. elegans.
DR   CTD; 185331; -.
DR   WormBase; F35H10.7a; CE04507; WBGene00018072; nprl-3.
DR   eggNOG; KOG3830; Eukaryota.
DR   InParanoid; Q20069; -.
DR   OMA; NIRFAGF; -.
DR   OrthoDB; 628619at2759; -.
DR   PhylomeDB; Q20069; -.
DR   PRO; PR:Q20069; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00018072; Expressed in germ line (C elegans) and 4 other tissues.
DR   ExpressionAtlas; Q20069; baseline and differential.
DR   GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR   GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR   GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR   GO; GO:0038202; P:TORC1 signaling; IBA:GO_Central.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 2.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Lysosome; Membrane; Reference proteome.
FT   CHAIN           1..511
FT                   /note="GATOR complex protein NPRL3"
FT                   /id="PRO_0000220640"
FT   REGION          37..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..58
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   511 AA;  57918 MW;  5B64C4FDC01154B9 CRC64;
     MSAKEVDFER ESHLHAVMCF LTGQSGEKIV SIYPHRKPAT KAPSKDPQPS SSNPGQCVKP
     VLTSVKDPSY GFGRVDTEFD MSLGMLAYVF KTQEIACNDG FDMKINNQRF VAYPKTWKAR
     GESTNYQISI VFALKNGCEQ HTASAYQTLS NKIAVSLVML QNYFGFLERE DKWADNAEEP
     NKDHPLEEFA KTSFIVQPLA EMFEEVRNRG NIHKYLINFV ELGFCDEAHA LTKLNVVPKG
     RQEIDEIVRK MKPYHGILLL EDVWPTPDAN PIVAKLLSHC SPDRSILDMS TASGIPIFEV
     FMIIRHLLQW TRAILIYPLC NTNIYTSATS PQPLDKMAEK FTAQFGNTIH LAAGLAHFNP
     PKTLDTFIRK NLPLHEQGVR AKLVVALLRH QMLMQLHQFY YILKPYSIAI LPEPKEPCPA
     EFTKIIEEST LPNDVKGVVA DICAEMLETT SYASVKRTLS LFVKVAPMMD GNHHLEEIKY
     KNNLDRTEIE GVFVSFKLVI ATFRRPDFVA E