ID   NPR3_PICGU              Reviewed;         787 AA.
AC   A5D9Y9;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=NPR3; Synonyms=RMD11; ORFNames=PGUG_00094;
OS   Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539
OS   / NBRC 10279 / NRRL Y-324) (Yeast) (Candida guilliermondii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Meyerozyma.
OX   NCBI_TaxID=294746;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; CH408155; EDK35996.2; -; Genomic_DNA.
DR   RefSeq; XP_001486717.1; XM_001486667.1.
DR   AlphaFoldDB; A5D9Y9; -.
DR   STRING; 4929.XP_001486717.1; -.
DR   EnsemblFungi; EDK35996; EDK35996; PGUG_00094.
DR   GeneID; 5128770; -.
DR   KEGG; pgu:PGUG_00094; -.
DR   eggNOG; ENOG502QW35; Eukaryota.
DR   HOGENOM; CLU_014314_0_0_1; -.
DR   InParanoid; A5D9Y9; -.
DR   OMA; CLPQKVH; -.
DR   OrthoDB; 628619at2759; -.
DR   Proteomes; UP000001997; Unassembled WGS sequence.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..787
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301805"
FT   REGION          25..89
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          121..182
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          233..262
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          661..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..71
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        72..89
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..182
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        242..262
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        676..693
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   787 AA;  89396 MW;  27FCC14156D90B1C CRC64;
     MSFNIPNPSL LGIFLVISTH SGPTSVFSYP PELSSDKTSS QRRNRHEDNE DYNDQNNAPE
     EQKTNVKVDD EDDDGLSSEE SDFSDEQFLL NEEWDSRNVN YYMGTKKDLL SFLDDEEKRR
     RSSGKERLRA PLSPELQPVI SQENNSPSSN NLKKTVSEVS DSQQSSSSRN SGSNRKSSSA
     QTAKDNILGF DKEYLCELLC PPRSMCNSRF EITVDDHVFI GLPVHCYDNG SWRHKTKTKS
     TRSGSKVSAD GQLYEDSQNS NSTSRATMSM FHLVFIMDPP VVEYNYRVDE MFHFVISRLA
     LVLRYEQSKH DYVWKQVKLI SKLKEDHRLS QGNDEGLHEF LVNRSSLCRS IKDCYEAISK
     HDIANLFVNK KLRSFQIPIK TEFHSLPEPT VPHLPGSYLS TTVNLLAGTG LINIGETTRY
     GMQGSLSSIT PGSTYDADED SLQTDSGSKT DDIIYFSLLL LDDPNSIIRD INAEPQSAIA
     RFIHSIKPTE SLERLAHKLN HHEKMESNIA EVKSFAFHLV YWRRARVIQP LSSRSVYIVS
     PMAPLSFNLY NDIKAFKAAF SSLPSLPHFL KLLSASSRKP KQFAAAIPSK DHRDIYMEAL
     GWLMKYGYVT QLHTFVWLKI SKKIKMKVEE DIEKESAGRK RSNPVTPSVE KYHKLLATDN
     TSKAYSDGPS DANIRRTRAN KPSSSPSSGI GVNSNPYNTD IVLEKDGDTI ILDPGRASSL
     ERKWINKIIF DECKLTPAMV SVFYKFLKYM NGKNSLELLL LKENVSRHDL RKLMFAIEDH
     IISVRHW