ID   NPR3_NEOFI              Reviewed;         841 AA.
AC   A1D3A0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 68.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=npr3; Synonyms=rmd11; ORFNames=NFIA_015860;
OS   Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164
OS   / JCM 1740 / NRRL 181 / WB 181) (Aspergillus fischerianus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=331117;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181
RC   / WB 181;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; DS027688; EAW22893.1; -; Genomic_DNA.
DR   RefSeq; XP_001264790.1; XM_001264789.1.
DR   AlphaFoldDB; A1D3A0; -.
DR   STRING; 36630.CADNFIAP00001554; -.
DR   EnsemblFungi; EAW22893; EAW22893; NFIA_015860.
DR   GeneID; 4591740; -.
DR   KEGG; nfi:NFIA_015860; -.
DR   VEuPathDB; FungiDB:NFIA_015860; -.
DR   eggNOG; KOG3830; Eukaryota.
DR   HOGENOM; CLU_014314_1_0_1; -.
DR   OMA; ARTDYVW; -.
DR   OrthoDB; 628619at2759; -.
DR   Proteomes; UP000006702; Unassembled WGS sequence.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..841
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301803"
FT   REGION          30..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          221..301
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          656..698
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        55..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        85..105
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        122..139
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        140..155
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        267..298
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        672..698
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   841 AA;  92648 MW;  FE5DE36EF6257DD2 CRC64;
     MSSIARPPDP CLVAIILIVR SRAGPRFVFH YPPNPLSENG LRPVRKERRT SRSKNGQGYK
     SNESSSSEES GSSSDDDEDE HQRQLQSQNQ SQSHLSGSVV SGRRSSNFGL DDHVAMSVSP
     GGDSQRAGSM GSGRTSFRKR GGNSDVEEDS GAASDRQEDG SGGAGGPYRP PWESLLGLPA
     DVWEKLLSPS PAWHKRRFEV GINDLAFIGW PVFVREDGTW RKQRRKKKKK WRAEWEGGEL
     GHNENAEDAP DDEDGDAGGN ASGGGGLMAA STETLSPKQM ALSEAKRGSG SSSKAARSSV
     DCLDGDDKDS MTMFNVVFVL DPPLLEYSMR TREIYDNIIK KFAKALKWEQ ARTDYVWREA
     QHISHLKEKA KERRTSLNTL YTELINQSSL ARAIYTVYTS ISASKIASVQ LSPDVSISLQ
     IPPLTSTPYL PGPTDKAYPG LWLTTADSVT PVEDPTADEN TAPHQVLAKH FALLLLDNEA
     AILKDVEASG GALAPALAHY LRCSKPTKSF AQISASSGIP LSTIQMLASH LVYWRRARAI
     PPIHQRDTYI VSPNCDLSKL EIATAAYQVA FPTLPSLPKM LSALSGTPRP YGSFIPSKDH
     KETYFAILAW LLRGGWVTQL RSFARVKVTP EIKMAVEVAL RREEVDKYLR KGRSLEAQKS
     ADGENGNEAD ENDDASSSSS SSLASQGSGD ETPMPGRYQQ ESNLRLSHSM LDRNTSLRTS
     SLILFPHRAS PLESRWLEQI VSRFPEHPRT AGRHRRGEGS NAAGGEIDPE YAALSTPMKD
     LWPTYIKYFN GLDALEKIPV REGLKRKLVW QVLTRLGLVT SQQSSIELDP REQVLVSVRH
     W