ID   NPR3_LODEL              Reviewed;         828 AA.
AC   A5E0E7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-JUN-2007, sequence version 1.
DT   03-AUG-2022, entry version 55.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=NPR3; Synonyms=RMD11; ORFNames=LELG_03084;
OS   Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC
OS   1676 / NRRL YB-4239) (Yeast) (Saccharomyces elongisporus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade;
OC   Lodderomyces.
OX   NCBI_TaxID=379508;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 11503 / BCRC 21390 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL
RC   YB-4239;
RX   PubMed=19465905; DOI=10.1038/nature08064;
RA   Butler G., Rasmussen M.D., Lin M.F., Santos M.A.S., Sakthikumar S.,
RA   Munro C.A., Rheinbay E., Grabherr M., Forche A., Reedy J.L., Agrafioti I.,
RA   Arnaud M.B., Bates S., Brown A.J.P., Brunke S., Costanzo M.C.,
RA   Fitzpatrick D.A., de Groot P.W.J., Harris D., Hoyer L.L., Hube B.,
RA   Klis F.M., Kodira C., Lennard N., Logue M.E., Martin R., Neiman A.M.,
RA   Nikolaou E., Quail M.A., Quinn J., Santos M.C., Schmitzberger F.F.,
RA   Sherlock G., Shah P., Silverstein K.A.T., Skrzypek M.S., Soll D.,
RA   Staggs R., Stansfield I., Stumpf M.P.H., Sudbery P.E., Srikantha T.,
RA   Zeng Q., Berman J., Berriman M., Heitman J., Gow N.A.R., Lorenz M.C.,
RA   Birren B.W., Kellis M., Cuomo C.A.;
RT   "Evolution of pathogenicity and sexual reproduction in eight Candida
RT   genomes.";
RL   Nature 459:657-662(2009).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; CH981527; EDK44905.1; -; Genomic_DNA.
DR   RefSeq; XP_001525156.1; XM_001525106.1.
DR   AlphaFoldDB; A5E0E7; -.
DR   STRING; 379508.A5E0E7; -.
DR   EnsemblFungi; EDK44905; EDK44905; LELG_03084.
DR   GeneID; 5232414; -.
DR   KEGG; lel:LELG_03084; -.
DR   VEuPathDB; FungiDB:LELG_03084; -.
DR   eggNOG; ENOG502QW35; Eukaryota.
DR   HOGENOM; CLU_014314_0_0_1; -.
DR   InParanoid; A5E0E7; -.
DR   OMA; ARTDYVW; -.
DR   OrthoDB; 628619at2759; -.
DR   Proteomes; UP000001996; Unassembled WGS sequence.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..828
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301802"
FT   REGION          49..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          127..207
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          644..688
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..81
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        127..163
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        173..204
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        646..688
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   828 AA;  94624 MW;  38E17D0C2FDAC0D1 CRC64;
     MSRNLPNPSL VGILFVVSTH SGPQLLYKYP HNLTDRVFSL VPRKHAGTED GMQHLVRDDK
     DDDDDDELYE YNEDEDPESG DLLFFDKDGT SRDRSGINVI SDTNHSQYYY GTKLELKRTL
     DEGRALRRAT PHKYNHNRLS TEHPKRNEHS QGSKSRRSIR NTDTTQDDNY QKQKGQQEGR
     EKKDKDKEKE KEKDAEEKGD VSEPHSAVDT FSIADDIFGM APGYLCEILS PPRQMCNTRY
     EVTIQDKIFL GLPIHQHADG TWTNARSSKR SQSGRSNSLH FENLTSSTEA QLASTTAQSL
     TMFHLVFIMN PPATECSYRI DEMFQHVASR TSLGLRLAQQ KHNYVGNQMK AIQRAREQEC
     KEVDLDKTLS LCKLIKECYL AISTSRIANL EIDGKQVVCQ IPTKYEFDSL PEPSVPYIPR
     SFLSSSIHSF GMWDRSNIEQ QKLDDDFLQE SIMCFALLLL AEPHNILQDM NIVTNSPFGK
     FIMLLHPSES LLKFCSKNSQ HFEPSEVKSY ALHLIYWKKA RAIQPLSSRS VYVASPMASL
     TTKLFEDIYR FKARFPMSPS LPQFLKLLSP QLKKPQQFAS IIPSRDHRAS YFEALAWLIR
     FGYVNQQLTF VWLKIPKNLR VKVEEDMENE DALLKRNKDR VFGEKSQTTD NTSKTMAVQE
     SPHNNDITTT RDTKISNNRN NGSDFDTDAD ANVNVNSDAN TSTNAAVANT AAGLVDARKD
     SLINATTETT ESQTERLKKQ LTLSVVDDED TIILEPGRAS TLERRWINEI ISVCKLSHDL
     IAIFYKLLKF MNGKTPLEFL IIKNEISRLD LKKLLYAIGN YIVSVRHW