ID   NPR3_KLULA              Reviewed;         844 AA.
AC   Q6CJJ1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=NPR3; Synonyms=RMD11; OrderedLocusNames=KLLA0F18238g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; CR382126; CAG98606.1; -; Genomic_DNA.
DR   RefSeq; XP_455898.1; XM_455898.1.
DR   AlphaFoldDB; Q6CJJ1; -.
DR   STRING; 28985.XP_455898.1; -.
DR   EnsemblFungi; CAG98606; CAG98606; KLLA0_F18238g.
DR   GeneID; 2895594; -.
DR   KEGG; kla:KLLA0_F18238g; -.
DR   eggNOG; ENOG502QW35; Eukaryota.
DR   HOGENOM; CLU_014314_0_0_1; -.
DR   InParanoid; Q6CJJ1; -.
DR   OMA; ARTDYVW; -.
DR   Proteomes; UP000000598; Chromosome F.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IEA:EnsemblFungi.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:EnsemblFungi.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IEA:EnsemblFungi.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:EnsemblFungi.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblFungi.
DR   GO; GO:1903833; P:positive regulation of cellular response to amino acid starvation; IEA:EnsemblFungi.
DR   GO; GO:0007124; P:pseudohyphal growth; IEA:EnsemblFungi.
DR   GO; GO:2000785; P:regulation of autophagosome assembly; IEA:EnsemblFungi.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..844
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301801"
FT   REGION          53..113
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..310
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        59..113
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        246..261
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        262..288
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   844 AA;  96739 MW;  5651E2BB476B3BCA CRC64;
     MSTNLPNSCL VQIALTVSTH SGPQLIYHYP PSNYATATNS KKTHHPDIKK RYEYTDSENN
     SSSDDYSSGL SDSELSTDYA DCSSDASESS LDSLPQSNHE DTVNSSTNNT FINNGLRSRQ
     SQISANKLFQ VLNQNNNNVA INGENSLRES LHSIRTSTNM SSTTDPRPED ELDAVDEELK
     ILVDDLLDGS IFQQDTFQDI SKVLNFNTEF VAELCSPRKE MCNTRFEFTV DDLCFLGLPI
     HADHKGRWKK SKKRKQASKR SARSSTARNS ISRNSVGRNS IGRNRSKTES QGHINDVEEP
     ADDENSDYEP SKSEMLNEMY CVPDAENDEF ESLQQSINMF QVCFIMNPKI IEYNERVDDM
     YHYVVTRLSL ILRYIQGKTG YVTRECVKIM KCKDEVSKHS RYYESLKSPW SKGKYMYERI
     LYESSLARAL TKCFNCIHNN EIANLEIDGD KIVSLQIPIK NEFSILPNLK EDAVLRGSFL
     SSILNESFIG RSTSLTNEDS DNLYANHDRL LDYGLLLLDE PENIIKGLEN ASFDNGVTDL
     LLINLVRQLK PTIRLGQYKL LIKELIDSND SSYDDQFCET TLKSLCLHLI YWRHARLILP
     ISSRNTYIVS PLAPISGFST DDFKHGEYDT LIRQQEVPVN NNDEPSLIYQ NKKVFNEKFP
     SLPSLPSFLQ LMSTQKPRPF GHIIPSNEHK SMYLNALAWL MRYGYLTQLL TFVYVRVDKR
     IKIAVDEDLE KDNLRSNKHE KSGNFVTGGE NYNSSEFDDL EMINDNDFTI ILEPERNTAL
     EKRWLYKCAE ALPTDLQTLF RQVVKYFNGK VSLEYIMIKE GIPKNEIKRL LQALGKYIVE
     VKHW