ID   NPR3_DEBHA              Reviewed;         821 AA.
AC   Q6BQU8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   16-DEC-2008, sequence version 2.
DT   25-MAY-2022, entry version 76.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=NPR3; Synonyms=RMD11; OrderedLocusNames=DEHA2E02046g;
OS   Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990
OS   / NBRC 0083 / IGC 2968) (Yeast) (Torulaspora hansenii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Debaryomyces.
OX   NCBI_TaxID=284592;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; CR382137; CAG87633.2; -; Genomic_DNA.
DR   RefSeq; XP_459422.2; XM_459422.1.
DR   AlphaFoldDB; Q6BQU8; -.
DR   STRING; 4959.XP_459422.2; -.
DR   EnsemblFungi; CAG87633; CAG87633; DEHA2E02046g.
DR   GeneID; 2902676; -.
DR   KEGG; dha:DEHA2E02046g; -.
DR   VEuPathDB; FungiDB:DEHA2E02046g; -.
DR   eggNOG; ENOG502QW35; Eukaryota.
DR   HOGENOM; CLU_014314_0_0_1; -.
DR   InParanoid; Q6BQU8; -.
DR   OMA; CLPQKVH; -.
DR   OrthoDB; 628619at2759; -.
DR   Proteomes; UP000000599; Chromosome E.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..821
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301799"
FT   REGION          29..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          116..194
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          246..283
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          654..694
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        38..59
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        116..151
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..194
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        665..688
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   821 AA;  93491 MW;  71F0C350D3BFD00A CRC64;
     MSLNLPNPSI LGILLVVSTH SGPQLVFQYP PDLSNDSKKS SNLKRTNKTS TLQRKDSDSD
     ELDIDDDDYI ADNENDEEFV NADNDEEKEW DSRKMNYYLG TKSDLLSFLD EQEKFRQTSQ
     ERNKIYGHKQ SDSHIDPDEI KSLHRNSKSG SSDKQIESPK LEASNSNNLK KTISSISDSQ
     KSSTSKASTS GIPPVSPITS STILGFEADY LCEMLCPPKQ MCNSRFEIMI DDLVFLGLPI
     HSYDNGSWKS KHSHRPKSGK SSKGRSKNAA DNASIDEGID YETTSKSQSK NSMSMFHLVF
     IMNPPIIECN YRIDEMFHYV ISRLSLVLRY EQSKHEYVWN QIRMIYNLKE EFRNQATMAN
     LTKYLTDKSS LCKLISECFT QISRSNIANL SINNKLRSFQ IPIKTEFHSL PDSTVPYLPG
     SHLSSTVNML ANTGLISVGE TIRYDVNNLN SGGLDDFDDI DDNKSDSNAD DIIYYALLLL
     DDPETIIRDI KAQQQSTLAN FIRMIKPTES LLKLANKLKQ QASDNGFSLD AGQIKSFAFH
     LIYWRRARVI LPISTRSVYI VSPMAPITLK FHHDIFIFKK TFPALPSLPH FLKLLSNSSK
     PRQLATVIPS KDHRDAYLNA LSWLIRYGYV TQLHTFIWLK ISRKIKMKVE EDLENEGANN
     KRKKPSATAD PNISNKLNAG TDNTSKTESN PEDIQRKMSQ LRMINRNNNG NPTSYEQEID
     NIEKKLLSPS IGLNLVLEDE GDTIIIDPGR ASSLERRWIN KVISEECNLS PELTVKFYEL
     LKYMNGKNSL ELLLLKENVS RQELRTLLFA IEDHIISVRH W