ID   NPR3_COCIM              Reviewed;         766 AA.
AC   Q1DHE5; A0A0D6K9M1; I9NSM7;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 1.
DT   25-MAY-2022, entry version 58.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=NPR3; Synonyms=RMD11; ORFNames=CIMG_10268;
OS   Coccidioides immitis (strain RS) (Valley fever fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Onygenaceae; Coccidioides.
OX   NCBI_TaxID=246410;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=RS;
RX   PubMed=19717792; DOI=10.1101/gr.087551.108;
RA   Sharpton T.J., Stajich J.E., Rounsley S.D., Gardner M.J., Wortman J.R.,
RA   Jordar V.S., Maiti R., Kodira C.D., Neafsey D.E., Zeng Q., Hung C.-Y.,
RA   McMahan C., Muszewska A., Grynberg M., Mandel M.A., Kellner E.M.,
RA   Barker B.M., Galgiani J.N., Orbach M.J., Kirkland T.N., Cole G.T.,
RA   Henn M.R., Birren B.W., Taylor J.W.;
RT   "Comparative genomic analyses of the human fungal pathogens Coccidioides
RT   and their relatives.";
RL   Genome Res. 19:1722-1731(2009).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=RS;
RX   PubMed=20516208; DOI=10.1101/gr.103911.109;
RA   Neafsey D.E., Barker B.M., Sharpton T.J., Stajich J.E., Park D.J.,
RA   Whiston E., Hung C.-Y., McMahan C., White J., Sykes S., Heiman D.,
RA   Young S., Zeng Q., Abouelleil A., Aftuck L., Bessette D., Brown A.,
RA   FitzGerald M., Lui A., Macdonald J.P., Priest M., Orbach M.J.,
RA   Galgiani J.N., Kirkland T.N., Cole G.T., Birren B.W., Henn M.R.,
RA   Taylor J.W., Rounsley S.D.;
RT   "Population genomic sequencing of Coccidioides fungi reveals recent
RT   hybridization and transposon control.";
RL   Genome Res. 20:938-946(2010).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; GG704915; EAS27663.1; -; Genomic_DNA.
DR   RefSeq; XP_001239246.1; XM_001239245.2.
DR   AlphaFoldDB; Q1DHE5; -.
DR   STRING; 246410.Q1DHE5; -.
DR   PRIDE; Q1DHE5; -.
DR   EnsemblFungi; EAS27663; EAS27663; CIMG_10268.
DR   GeneID; 4557948; -.
DR   KEGG; cim:CIMG_10268; -.
DR   VEuPathDB; FungiDB:CIMG_10268; -.
DR   InParanoid; Q1DHE5; -.
DR   OMA; ARTDYVW; -.
DR   OrthoDB; 628619at2759; -.
DR   Proteomes; UP000001261; Unassembled WGS sequence.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..766
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301798"
FT   REGION          33..140
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          186..257
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          594..638
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..64
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        73..110
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        111..134
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..256
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        607..638
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   766 AA;  84993 MW;  D4581FFE93BFBC2F CRC64;
     MSSVVRPPDP CLVAIILITC SRAGPRFVYH YPPNPSIASA PSRSNSRTKP SPRASDSSPS
     SDNEEGSSSD EDDLSQTPRI GSPRPTNVRR LSSGSPSTKA ASQQRKSNLG GSELDDTETP
     RDGRRSERSH ELENPPWDSF LGLGTDVWEK LLCPSSSWHK RRFEVGVNDL TFVGWPVFVR
     EDGTWRKKRK KKKTRAGDSV LDTAPTLGSE KGGYADGGEK LESERDPNVD GRSDKDEEPS
     RSLIESHPDE DGSVTDGTKD AMTMFNVVFV MNPPILEHNL RIKENYDNVI KKFGKGLKSE
     QATANYVWKE AQKILHIKEK GRENKSSLSS VYEELLSQSS LAQAIATIYR SISTSKIASI
     TLTPHTTMSL QIPPLTSTPY LPGPMEPAYP GLWLTTADSL SATDEVTEME YSGPSKVLAK
     HFALLLLSDE ASILKDIEAS MGTLGPPLAH YIRSSKPTKS FAQISARSSI PLNDIQVLAA
     HLIYWRRARA VPPLNKQDTY IVSPNCDLSK LGLATAAYEL AFPTMPSLPK MLAVLSGTPR
     PYASFIPSRD HKGIYYDILA WLMRGGWVTQ LRTFGWIKVD QELKSAVEEA LASEEAKERE
     EELASSTATV IRVNEPQTDD GASTSSSSLD SEHSNATPVQ ERFAHFQGHQ KGHDPAQISS
     LILRPHRASP LEARWLDEII SRFPDDHLAD RANESEDFEG EVSIHRYWNA FTKYFNGTDA
     LEKIPVREGL SRKLVWRLLS RIDISSNPAD GEVHRNEKVL VTVRHW