ID   NPR3_CANGA              Reviewed;         946 AA.
AC   Q6FVA1;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   19-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 82.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=NPR3; Synonyms=RMD11; OrderedLocusNames=CAGL0E03608g;
OS   Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL
OS   Y-65) (Yeast) (Torulopsis glabrata).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Nakaseomyces;
OC   Nakaseomyces/Candida clade.
OX   NCBI_TaxID=284593;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; CR380951; CAG58762.1; -; Genomic_DNA.
DR   RefSeq; XP_445843.1; XM_445843.1.
DR   AlphaFoldDB; Q6FVA1; -.
DR   STRING; 5478.XP_445843.1; -.
DR   EnsemblFungi; CAG58762; CAG58762; CAGL0E03608g.
DR   GeneID; 2887419; -.
DR   KEGG; cgr:CAGL0E03608g; -.
DR   CGD; CAL0129006; CAGL0E03608g.
DR   VEuPathDB; FungiDB:CAGL0E03608g; -.
DR   eggNOG; ENOG502QW35; Eukaryota.
DR   HOGENOM; CLU_014314_0_0_1; -.
DR   InParanoid; Q6FVA1; -.
DR   OMA; ARTDYVW; -.
DR   Proteomes; UP000002428; Chromosome E.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IEA:EnsemblFungi.
DR   GO; GO:1990130; C:GATOR1 complex; IEA:EnsemblFungi.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0051058; P:negative regulation of small GTPase mediated signal transduction; IEA:EnsemblFungi.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IEA:EnsemblFungi.
DR   GO; GO:0010508; P:positive regulation of autophagy; IEA:EnsemblFungi.
DR   GO; GO:1903833; P:positive regulation of cellular response to amino acid starvation; IEA:EnsemblFungi.
DR   GO; GO:0007124; P:pseudohyphal growth; IEA:EnsemblFungi.
DR   GO; GO:2000785; P:regulation of autophagosome assembly; IEA:EnsemblFungi.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..946
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301797"
FT   REGION          48..171
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          283..334
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          813..849
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        86..129
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        137..168
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..334
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        825..842
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   946 AA;  108046 MW;  89435938D98D8AC1 CRC64;
     MNEFLPDSCL LGVMLAVSSH SGPQVIYHYP PSNRILETAR DAHMNQQLGT TGLKRETEGR
     SMKSRGHPGN WDMNSELDSD LHSSKMERTA SSSSSSSLSS PSSGLSDSEL STDYADWSTS
     GSSSDSELDL QTPDDSRRSQ LENAGARSTR NVSPVSMSRN TSLGREPKDN GQKISASKLL
     DILNDPKSQF TKINTNDTND DQFNMEEDDD LIEFDYMTSE KRVDITEEFF TEANYQDTSK
     FFEFDIDFLA ELCCPSREMC NTRFELTVDE YCFLGHPIHV DSSGNWRKSR KRNNSLSKSK
     RSGSLTGSRK RSGSKSSNHD KSFSAETPNS PESSKIIEEV GSLHKSRTLS NPQNDHFTKD
     MTMFHVCFIM DPNLIEYNKR VDDMYQYVVA RLSVLLRYLQ SKNDYVSEQC ELILKEKEKV
     FKNSKHYKSL SLPSEKGRYL YQRLLAKSSL ARALTECVEK IKKNEIACLE ITDHRTVSLQ
     IPIQNEFSIL PQYKLYPVLK GSFLTSIQNN KFLEKSANID DNHHAKSARD TNLISDHVNT
     FSNGQTKNEI FYSKNMENAL TAQNDYDDDD LLLYSILLLD DPDKIIADLD NYSSNDDIGG
     VILKQLVKVI QPNVPLLSYQ YIINELLAEK PLSSSTTANK SKQNKDNKTN TFYSALLRSC
     ALHLIYWRHA RAILPISFKN TYIVSPLSPV EADNSEMIKG NRKPSITDLN VTSNSSSKIP
     VIYLNQQSFK LKFPSLPSLP TFLNILSLGK PKAFGNIIPS KEHKPIYMAA LIWLIQKGYL
     TQLLTFVYIR VDKKIKMKVD EDLEKEGFRT NRRRRQEDNV DNKLLSTDEN ANEPPKSTKV
     DINDNTLEGR DTEYDSDSFD YDDPEFNHDY TIILEPERAT ALEKRWIYKC IQDQPQDIKI
     LFNKVMKYMN GRTAMETVML KEHISRHDIK RLLTSLGNYI VELNHW