ID   NPR3_CANAL              Reviewed;         715 AA.
AC   Q5A319; A0A1D8PTU8;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   26-APR-2005, sequence version 1.
DT   03-AUG-2022, entry version 78.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=NPR3; Synonyms=RMD11; OrderedLocusNames=CAALFM_CR08680CA;
GN   ORFNames=CaO19.13802, CaO19.6444;
OS   Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Debaryomycetaceae; Candida/Lodderomyces clade; Candida.
OX   NCBI_TaxID=237561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=15123810; DOI=10.1073/pnas.0401648101;
RA   Jones T., Federspiel N.A., Chibana H., Dungan J., Kalman S., Magee B.B.,
RA   Newport G., Thorstenson Y.R., Agabian N., Magee P.T., Davis R.W.,
RA   Scherer S.;
RT   "The diploid genome sequence of Candida albicans.";
RL   Proc. Natl. Acad. Sci. U.S.A. 101:7329-7334(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=17419877; DOI=10.1186/gb-2007-8-4-r52;
RA   van het Hoog M., Rast T.J., Martchenko M., Grindle S., Dignard D.,
RA   Hogues H., Cuomo C., Berriman M., Scherer S., Magee B.B., Whiteway M.,
RA   Chibana H., Nantel A., Magee P.T.;
RT   "Assembly of the Candida albicans genome into sixteen supercontigs aligned
RT   on the eight chromosomes.";
RL   Genome Biol. 8:RESEARCH52.1-RESEARCH52.12(2007).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], AND GENOME REANNOTATION.
RC   STRAIN=SC5314 / ATCC MYA-2876;
RX   PubMed=24025428; DOI=10.1186/gb-2013-14-9-r97;
RA   Muzzey D., Schwartz K., Weissman J.S., Sherlock G.;
RT   "Assembly of a phased diploid Candida albicans genome facilitates allele-
RT   specific measurements and provides a simple model for repeat and indel
RT   structure.";
RL   Genome Biol. 14:RESEARCH97.1-RESEARCH97.14(2013).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; CP017630; AOW31547.1; -; Genomic_DNA.
DR   RefSeq; XP_716281.1; XM_711188.1.
DR   AlphaFoldDB; Q5A319; -.
DR   STRING; 237561.Q5A319; -.
DR   GeneID; 3642127; -.
DR   KEGG; cal:CAALFM_CR08680CA; -.
DR   CGD; CAL0000182919; orf19.13802.
DR   VEuPathDB; FungiDB:CR_08680C_A; -.
DR   eggNOG; ENOG502QW35; Eukaryota.
DR   HOGENOM; CLU_014314_0_0_1; -.
DR   InParanoid; Q5A319; -.
DR   OMA; CLPQKVH; -.
DR   OrthoDB; 628619at2759; -.
DR   PRO; PR:Q5A319; -.
DR   Proteomes; UP000000559; Chromosome R.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR   GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR   GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR   GO; GO:0038202; P:TORC1 signaling; IBA:GO_Central.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 2.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..715
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301796"
FT   REGION          104..149
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          562..621
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        104..127
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        128..149
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        570..595
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        596..621
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   715 AA;  81904 MW;  6F3319FD2FB1EBDA CRC64;
     MSLNLPNPSL IGILLVISTH SGPQLIYKYP FDLSNDPSRD ESKYALDDNE DDELYDHEES
     EDENEVNENE MYGVNSRNWD SKHIDYYMGT KSDLLKFLDE QDSRRRKITT TSPSEEKHTK
     EKHGLTKTIS KSSTMASSST TSPPESSIQG EIFGTDAAYI CEMLAPPKQM CNTRFEMTIQ
     DKLFLGLPVH RSDNGQWRSI GHNNEHDEEE THTAKNSLNM FHLVFVMNPP VIESNYRVDE
     MFHYVISRLS LVLRYEQQKH DYVSQQVKNI LALRESLEGN ESLLTEKSSL SRVIRDCFEG
     ISTSTIANLS INGKLRSFQI PIKTEFHSLP DPSVPFLPAS YLSSTVELLG DTSFINVGET
     SRYGHAFNSV QDEENSAEKI IVYFALLLLD DPESIIKDMK TETDSTLAKF IRMIEPTESL
     LKLSARNSKL DISQIKDFAF HLIYWRRARV ILPLSSRSVY IVSPMAPITI KLYDDISFFN
     RRFPTLPSLP HFLKLLSPQS RKPQQFATVI PSKDHRDRYL QALGWLIKHG YVTQLQTFIW
     LKISRKIKIK VEEDIENENL AKKKKKQKNG SVTVATANSS KTEAPIMPTD NTSKQVSDSK
     DSDKPEDDEY ASKPRLDGLH EHIDGTPIVT LVQGDDTIIL DPGRATTLER RWINKIIYEE
     CKLSPELTAV FYKLLKYMNG KNSLELLLLK ENISRSELRK LLLSIEEHII SVRHW