ID   NPR3_ASPCL              Reviewed;         869 AA.
AC   A1CQD6;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 1.
DT   25-MAY-2022, entry version 64.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=npr3; Synonyms=rmd11; ORFNames=ACLA_025740;
OS   Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 /
OS   NRRL 1 / QM 1276 / 107).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Aspergillus;
OC   Aspergillus subgen. Fumigati.
OX   NCBI_TaxID=344612;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1;
RX   PubMed=18404212; DOI=10.1371/journal.pgen.1000046;
RA   Fedorova N.D., Khaldi N., Joardar V.S., Maiti R., Amedeo P., Anderson M.J.,
RA   Crabtree J., Silva J.C., Badger J.H., Albarraq A., Angiuoli S., Bussey H.,
RA   Bowyer P., Cotty P.J., Dyer P.S., Egan A., Galens K., Fraser-Liggett C.M.,
RA   Haas B.J., Inman J.M., Kent R., Lemieux S., Malavazi I., Orvis J.,
RA   Roemer T., Ronning C.M., Sundaram J.P., Sutton G., Turner G., Venter J.C.,
RA   White O.R., Whitty B.R., Youngman P., Wolfe K.H., Goldman G.H.,
RA   Wortman J.R., Jiang B., Denning D.W., Nierman W.C.;
RT   "Genomic islands in the pathogenic filamentous fungus Aspergillus
RT   fumigatus.";
RL   PLoS Genet. 4:E1000046-E1000046(2008).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
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DR   EMBL; DS027059; EAW07857.1; -; Genomic_DNA.
DR   RefSeq; XP_001269283.1; XM_001269282.1.
DR   AlphaFoldDB; A1CQD6; -.
DR   STRING; 5057.CADACLAP00002856; -.
DR   EnsemblFungi; EAW07857; EAW07857; ACLA_025740.
DR   GeneID; 4701823; -.
DR   KEGG; act:ACLA_025740; -.
DR   VEuPathDB; FungiDB:ACLA_025740; -.
DR   eggNOG; KOG3830; Eukaryota.
DR   HOGENOM; CLU_014314_1_0_1; -.
DR   OMA; ARTDYVW; -.
DR   OrthoDB; 628619at2759; -.
DR   Proteomes; UP000006701; Unassembled WGS sequence.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:0032007; P:negative regulation of TOR signaling; IEA:InterPro.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..869
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301791"
FT   REGION          30..175
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          222..266
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          652..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          751..773
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        44..69
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        87..141
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..157
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        235..253
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        676..693
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   869 AA;  95856 MW;  AECEB4255837C4C5 CRC64;
     MSSIARPPDP CLVAIILIVR SRAGPRFVFH YPPNPLSENG LKPALRSRRT SRSRTGQGYK
     SNDSSSSEES GSSSDEDEDE HQHQLHSQSN NHSQTHLSGS VVSARRSSNF GLDDHVTMSV
     SPGGDSQRAG SIGSSRTLFR RRGGNSDVEE ESGAGSDRQE DGAGTAGGPN RPPWESLLGL
     PADVWEKLLS PSPAWHKRRF EVGINDLAFI GWPVFVREDG TWRKQKRKKK KEKKKARAEW
     EGGELGHNEN SEDAPDGEDG DGEGGGGLKL IVASTETLSP KHMTFSEAKR ASVASNLAAR
     ASSDCLDVDD KDSMTMFNVV FVLDPPLLEY SMRIKELYDN IIKKFAKALK WEQARTDYVW
     REAQHITHLK EKAKERRTSL NTLYSELINQ SSLARAIYTV FNSISASKIA SVPLSPDVSI
     SLQIPPLTST PYLSGPADKA YPGLWLTTAD SVTPVDDPTA EEIAAPHQVL AKNFALLLLD
     NEATILKDVE ASGGALAPAL AHYLRCSKPT KSFAQISATS GIPLSTIQML ASHLVYWRRA
     RAIPPIHQRD TYIVSPNCDL SKLEVATAAY QAAFPTLPSL PKMLSALSGT PRPYGSFIPS
     KDHKETYFAI LAWLLRGGWV TQLRSFARVK VTPEIKMAVE VALRREEVDK YLRKSRPSGP
     GKSGIDGEEG SGAEEVDDAS SSSSSSLSSH GSGEETPMPG RYKLESEMRL EHSLLDRNTS
     LRTASLILFP HRASPLESRW LEEIVSQFPD KPRSANRLRG HGSGSRGGEG DPECAGICTP
     MKDLWPTYIK YFNGLDALEK IPIRESLKRK LAWQVLTRLG MVTSQQTSIE LDPREQVLVS
     VRHWNNELIY FQFLIFPRDI NSIIPHHAR