ID   NPR3_ASHGO              Reviewed;         940 AA.
AC   Q750J0;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   09-JAN-2013, sequence version 3.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Nitrogen permease regulator 3;
DE   AltName: Full=Required for meiotic nuclear division protein 11;
DE   Flags: Precursor;
GN   Name=NPR3; Synonyms=RMD11; OrderedLocusNames=AGL039W;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION, AND SEQUENCE REVISION TO 589.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Mediates inactivation of the TORC1 complex in response to
CC       amino acid starvation. Required for meiotic nuclear division (By
CC       similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NPR3 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAS54451.2; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE016820; AAS54451.2; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_986627.2; NM_211689.2.
DR   AlphaFoldDB; Q750J0; -.
DR   STRING; 33169.AAS54451; -.
DR   GeneID; 4622926; -.
DR   KEGG; ago:AGOS_AGL039W; -.
DR   eggNOG; ENOG502QW35; Eukaryota.
DR   InParanoid; Q750J0; -.
DR   Proteomes; UP000000591; Chromosome VII.
DR   GO; GO:0097042; C:extrinsic component of fungal-type vacuolar membrane; IBA:GO_Central.
DR   GO; GO:1990130; C:GATOR1 complex; IBA:GO_Central.
DR   GO; GO:0034198; P:cellular response to amino acid starvation; IBA:GO_Central.
DR   GO; GO:0051321; P:meiotic cell cycle; IEA:UniProtKB-KW.
DR   GO; GO:1904262; P:negative regulation of TORC1 signaling; IBA:GO_Central.
DR   GO; GO:0010508; P:positive regulation of autophagy; IBA:GO_Central.
DR   GO; GO:0038202; P:TORC1 signaling; IBA:GO_Central.
DR   InterPro; IPR005365; Npr3.
DR   PANTHER; PTHR13153; PTHR13153; 1.
DR   Pfam; PF03666; NPR3; 1.
PE   3: Inferred from homology;
KW   Meiosis; Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..940
FT                   /note="Nitrogen permease regulator 3"
FT                   /id="PRO_0000301790"
FT   REGION          37..155
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          317..387
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          812..848
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        37..52
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..109
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        328..380
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        831..847
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   940 AA;  104770 MW;  B684B45EE2D28587 CRC64;
     MYTNLPKACL TGIVLTISTH SGPQVVYHYP PVKQPVEARR GRKVDSRNER VRSWQAGRMP
     SAASGAVDAV GEGVDGLEEE SSESELDRSS GLSESEVSTD WADYSMSSSD SESEMREDGG
     GESSAVGGSS AAEGGEESLA EGADSSIAWP GPSESYNQLL ESQSMVGSSA NVAAASTKPK
     SIKSRHSQIS ANKLFQYLTN TSDADSRRQS VFSKLTGNED SETIRLTDSV NLLDLESLLE
     DLEPGLADVD ISELLDVEVF QPGRFQDVSK IFNFDAEFVA ELCSPPKEMC NTRFELTVDD
     LCFLGLPIHV DESGRWRKQK VKRQQTNTRS KRSSSGGKPD AGSRTSVGLP HGTQERQPST
     DQSGSGAPYL AQSSSESGQL RDPEQSDDVE DLQKAVHMFH VCFIMNPQLV EYNERIDDMY
     HYIVTRLSLI LRYIQDKKGY VVRECAKILK TRDRILKKSL KLKKSHGQAL QGRYLYECIL
     KSSSLARALT KCFNSIINNE IVTLDIDNHK VISLQIPIKN EFSSLPDLKI NPVLRGSYLT
     SLLNDSFLKQ PVDFAAGSMM PGGDVMHDDN DVLDYALLLL DDTPKIIKDL EFSSFGSDLA
     NVIMINLVKN LKPTVSLRSY LPLVSNLLEA NLSLSARAAG SRHAASNAAD SHSTPLQHSM
     IRSIVLHLVY WRYARIILPL SSKNTYIVSP LAPIRGTAAD DFENTDMVKQ GCKALIYQHQ
     DLFHEKFPTL PTLPSFLSSI STCKPRSFGH LIPSKDHNLL YLSVLAWLIR YGYLTQLLTF
     VWLRVDRRIK IAVDEDLERE GVRTWNSIVK KEHRQNPHDN VAAPTREPAS SAIDETASSS
     EHGDANISDG QESLDDYLFK ESDYTIILEP KTATALEKRW LFKCIENQPT EMQLLFRKVI
     KYFNGKTPLE LVEIKENIPK QELKKLIACL DKYVVELKHW