NKAI4_HUMAN
ID NKAI4_HUMAN Reviewed; 208 AA.
AC Q8IVV8; Q4VXQ6; Q9BQU8; Q9BQU9;
DT 26-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 26-APR-2004, sequence version 2.
DT 03-AUG-2022, entry version 132.
DE RecName: Full=Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 4;
DE Short=Na(+)/K(+)-transporting ATPase subunit beta-1-interacting protein 4;
DE AltName: Full=Protein FAM77A;
GN Name=NKAIN4; Synonyms=C20orf58, FAM77A;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=11780052; DOI=10.1038/414865a;
RA Deloukas P., Matthews L.H., Ashurst J.L., Burton J., Gilbert J.G.R.,
RA Jones M., Stavrides G., Almeida J.P., Babbage A.K., Bagguley C.L.,
RA Bailey J., Barlow K.F., Bates K.N., Beard L.M., Beare D.M., Beasley O.P.,
RA Bird C.P., Blakey S.E., Bridgeman A.M., Brown A.J., Buck D., Burrill W.D.,
RA Butler A.P., Carder C., Carter N.P., Chapman J.C., Clamp M., Clark G.,
RA Clark L.N., Clark S.Y., Clee C.M., Clegg S., Cobley V.E., Collier R.E.,
RA Connor R.E., Corby N.R., Coulson A., Coville G.J., Deadman R., Dhami P.D.,
RA Dunn M., Ellington A.G., Frankland J.A., Fraser A., French L., Garner P.,
RA Grafham D.V., Griffiths C., Griffiths M.N.D., Gwilliam R., Hall R.E.,
RA Hammond S., Harley J.L., Heath P.D., Ho S., Holden J.L., Howden P.J.,
RA Huckle E., Hunt A.R., Hunt S.E., Jekosch K., Johnson C.M., Johnson D.,
RA Kay M.P., Kimberley A.M., King A., Knights A., Laird G.K., Lawlor S.,
RA Lehvaeslaiho M.H., Leversha M.A., Lloyd C., Lloyd D.M., Lovell J.D.,
RA Marsh V.L., Martin S.L., McConnachie L.J., McLay K., McMurray A.A.,
RA Milne S.A., Mistry D., Moore M.J.F., Mullikin J.C., Nickerson T.,
RA Oliver K., Parker A., Patel R., Pearce T.A.V., Peck A.I.,
RA Phillimore B.J.C.T., Prathalingam S.R., Plumb R.W., Ramsay H., Rice C.M.,
RA Ross M.T., Scott C.E., Sehra H.K., Shownkeen R., Sims S., Skuce C.D.,
RA Smith M.L., Soderlund C., Steward C.A., Sulston J.E., Swann R.M.,
RA Sycamore N., Taylor R., Tee L., Thomas D.W., Thorpe A., Tracey A.,
RA Tromans A.C., Vaudin M., Wall M., Wallis J.M., Whitehead S.L.,
RA Whittaker P., Willey D.L., Williams L., Williams S.A., Wilming L.,
RA Wray P.W., Hubbard T., Durbin R.M., Bentley D.R., Beck S., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 20.";
RL Nature 414:865-871(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ASP-173.
RC TISSUE=Brain, and Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- SUBUNIT: Interacts with ATP1B1. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8IVV8; P21145: MAL; NbExp=3; IntAct=EBI-17791123, EBI-3932027;
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the NKAIN family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AL121827; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC041812; AAH41812.1; -; mRNA.
DR CCDS; CCDS13514.1; -.
DR RefSeq; NP_690603.3; NM_152864.3.
DR AlphaFoldDB; Q8IVV8; -.
DR BioGRID; 126120; 4.
DR IntAct; Q8IVV8; 1.
DR STRING; 9606.ENSP00000359340; -.
DR TCDB; 8.A.118.1.5; the na+k+-atpase beta-subunit interacting nkain (nkain) family.
DR PhosphoSitePlus; Q8IVV8; -.
DR BioMuta; NKAIN4; -.
DR DMDM; 46576604; -.
DR PaxDb; Q8IVV8; -.
DR PRIDE; Q8IVV8; -.
DR Antibodypedia; 29667; 123 antibodies from 19 providers.
DR DNASU; 128414; -.
DR Ensembl; ENST00000370316.8; ENSP00000359340.3; ENSG00000101198.15.
DR GeneID; 128414; -.
DR KEGG; hsa:128414; -.
DR MANE-Select; ENST00000370316.8; ENSP00000359340.3; NM_152864.4; NP_690603.3.
DR UCSC; uc002yek.3; human.
DR CTD; 128414; -.
DR DisGeNET; 128414; -.
DR GeneCards; NKAIN4; -.
DR HGNC; HGNC:16191; NKAIN4.
DR HPA; ENSG00000101198; Group enriched (brain, kidney).
DR MIM; 612873; gene.
DR neXtProt; NX_Q8IVV8; -.
DR OpenTargets; ENSG00000101198; -.
DR PharmGKB; PA162397583; -.
DR VEuPathDB; HostDB:ENSG00000101198; -.
DR eggNOG; KOG4556; Eukaryota.
DR GeneTree; ENSGT00940000157989; -.
DR HOGENOM; CLU_090781_0_0_1; -.
DR InParanoid; Q8IVV8; -.
DR OMA; FMDYQYI; -.
DR OrthoDB; 1281511at2759; -.
DR PhylomeDB; Q8IVV8; -.
DR TreeFam; TF321348; -.
DR PathwayCommons; Q8IVV8; -.
DR SignaLink; Q8IVV8; -.
DR BioGRID-ORCS; 128414; 10 hits in 1063 CRISPR screens.
DR ChiTaRS; NKAIN4; human.
DR GenomeRNAi; 128414; -.
DR Pharos; Q8IVV8; Tdark.
DR PRO; PR:Q8IVV8; -.
DR Proteomes; UP000005640; Chromosome 20.
DR RNAct; Q8IVV8; protein.
DR Bgee; ENSG00000101198; Expressed in nucleus accumbens and 140 other tissues.
DR ExpressionAtlas; Q8IVV8; baseline and differential.
DR Genevisible; Q8IVV8; HS.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0002028; P:regulation of sodium ion transport; IBA:GO_Central.
DR InterPro; IPR008516; Na/K-Atpase_Interacting.
DR PANTHER; PTHR13084; PTHR13084; 1.
DR Pfam; PF05640; NKAIN; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..208
FT /note="Sodium/potassium-transporting ATPase subunit beta-1-
FT interacting protein 4"
FT /id="PRO_0000079437"
FT TRANSMEM 35..55
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 62..82
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical"
FT /evidence="ECO:0000255"
FT VARIANT 91
FT /note="K -> Q (in dbSNP:rs1129659)"
FT /id="VAR_037051"
FT VARIANT 131
FT /note="A -> D (in dbSNP:rs2236194)"
FT /id="VAR_037052"
FT VARIANT 151
FT /note="C -> G (in dbSNP:rs872808)"
FT /id="VAR_037053"
FT VARIANT 173
FT /note="E -> D (in dbSNP:rs11556207)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_037054"
SQ SEQUENCE 208 AA; 23240 MW; FE55FE54F1863CC3 CRC64;
MGSCSGRCAL VVLCAFQLVA ALERQVFDFL GYQWAPILAN FVHIIIVILG LFGTIQYRLR
YVMVYTLWAA VWVTWNVFII CFYLEVGGLL KDSELLTFSL SRHRSWWRER WPGCLHEEVP
AVGLGAPHGQ ALVSGAGCAL EPSYVEALHS CLQILIALLG FVCGCQVVSV FTEEEDSFDF
IGGFDPFPLY HVNEKPSSLL SKQVYLPA
