NFUA_KLEPN
ID NFUA_KLEPN Reviewed; 100 AA.
AC Q9EXI9;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 66.
DE RecName: Full=Fe/S biogenesis protein NfuA;
DE Flags: Fragment;
GN Name=nfuA; Synonyms=yhgI;
OS Klebsiella pneumoniae.
OC Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Klebsiella/Raoultella group; Klebsiella.
OX NCBI_TaxID=573;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=CG43;
RX PubMed=11598090; DOI=10.1128/iai.69.11.7140-7145.2001;
RA Lai Y.-C., Peng H.-L., Chang H.-Y.;
RT "Identification of genes induced in vivo during Klebsiella pneumoniae CG43
RT infection.";
RL Infect. Immun. 69:7140-7145(2001).
CC -!- FUNCTION: Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S
CC cluster, can transfer this cluster to apoproteins, and thereby
CC intervenes in the maturation of Fe/S proteins. Could also act as a
CC scaffold/chaperone for damaged Fe/S proteins (By similarity).
CC {ECO:0000250}.
CC -!- COFACTOR:
CC Name=[4Fe-4S] cluster; Xref=ChEBI:CHEBI:49883; Evidence={ECO:0000250};
CC Note=Binds 1 [4Fe-4S] cluster per subunit. The cluster is presumably
CC bound at the interface of two monomers. {ECO:0000250};
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NfuA family. {ECO:0000305}.
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DR EMBL; AJ292303; CAC19417.1; -; Genomic_DNA.
DR AlphaFoldDB; Q9EXI9; -.
DR SMR; Q9EXI9; -.
DR GO; GO:0051539; F:4 iron, 4 sulfur cluster binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR Gene3D; 2.60.300.12; -; 1.
DR InterPro; IPR000361; FeS_biogenesis.
DR InterPro; IPR035903; HesB-like_dom_sf.
DR Pfam; PF01521; Fe-S_biosyn; 1.
DR SUPFAM; SSF89360; SSF89360; 1.
PE 3: Inferred from homology;
KW 4Fe-4S; Iron; Iron-sulfur; Metal-binding.
FT CHAIN 1..>100
FT /note="Fe/S biogenesis protein NfuA"
FT /id="PRO_0000209477"
FT NON_TER 100
SQ SEQUENCE 100 AA; 10919 MW; CA618E9EB4EC3527 CRC64;
MIRISDAAQA HFAKLLANQE EGTQIRVFVI NPGTPNAECG VSYCPPDAVE DTDTALKFEQ
LTAYVDELSA PYLEDAEIDF VTDQLGSQLT LKARTPKCAK