ID   NEOR_STRCY              Reviewed;         437 AA.
AC   P14501;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-JAN-1990, sequence version 1.
DT   25-MAY-2022, entry version 45.
DE   RecName: Full=Neomycin resistance protein;
OS   Streptomyces cyanogenus.
OG   Plasmid pSB24.2.
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces.
OX   NCBI_TaxID=80860;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bolotin A.P., Sorokin A.V., Aleksandrov N.N., Danilenko V.N., Kozlov Y.I.;
RT   "Nucleotide sequence of DNA of the actinomycete plasmid pSB24.2.";
RL   Dokl. Biochem. 283:1014-1017(1985).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA   Bolotin A.P., Sorokin A.V., Aleksandrov N.N., Danilenko V.N., Kozlov Y.I.;
RT   "Nucleotide sequence of DNA of the actinomycete plasmid pSB24.2.";
RL   Dokl. Biochem. 283:260-263(1985).
CC   -!- SIMILARITY: Belongs to the Gram-positive plasmids replication protein
CC       type 1 family. {ECO:0000305}.
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DR   EMBL; X03756; CAA27389.1; -; Genomic_DNA.
DR   EMBL; M32513; AAA98338.1; -; Genomic_DNA.
DR   AlphaFoldDB; P14501; -.
DR   GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Antibiotic resistance; Plasmid.
FT   CHAIN           1..437
FT                   /note="Neomycin resistance protein"
FT                   /id="PRO_0000068503"
FT   REGION          161..285
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          305..338
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        215..231
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        324..338
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        111
FT                   /note="G -> R (in Ref. 2; AAA98338)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        220
FT                   /note="A -> P (in Ref. 2; AAA98338)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        356
FT                   /note="K -> N (in Ref. 2; AAA98338)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        412
FT                   /note="R -> G (in Ref. 2; AAA98338)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   437 AA;  47409 MW;  2AF729BAD04EB01B CRC64;
     MDPDAGVIFA RTAAGAAVAL GLLKCGRIWL CPVCSGQDPA RPSEEITEAV VSWLQQGGWA
     YLVTFTARHT AADRLSDLMD ALQGTRADAE TGTKRRPGAY QRLITGAAWA GDKRRKSNQE
     GIRGRIGYIG MIRATEVTVG EGAGWHPHIH AIVLVGGRTE GQRGDKRITG TFTPSEDALT
     EWEDRWRRSG PATLARSTPG FRPPTGARSP GATAGARATA STSSSSVRSG RQRPGRVHRQ
     DAGRQEPGPG AGTRRPQGRP PGQHDVLRTP SRIGDLMGGV PEEEAAGHGS LAWGLDRWAE
     YETAVSGAGH RVDPLPAPAP GPDRRRHRGR RHGRPVPDRR RRRFRDGVQI WDRAWKGLVG
     RSLDLAVVEA VEGREISMDA LGELVQSAGQ SRAFLRVLTP QEVTELYDEL LRTLARRREQ
     AAERRAAEAA EAEPTTR