ID   NEMS_APIME              Reviewed;          86 AA.
AC   P85527;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 47.
DE   RecName: Full=Myosuppressin;
DE   Flags: Precursor;
OS   Apis mellifera (Honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea; Apidae;
OC   Apis.
OX   NCBI_TaxID=7460;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DH4;
RG   Honey bee genome project;
RA   Zhang L., Deng J., Wu Y.-Q., Kovar C., Aqrawi P., Bandaranaike D.,
RA   Blankenburg K., Chen D., Denson S., Dinh H., Firestine M., Gross S.,
RA   Han Y., Hernandez B., Holder M., Jackson L., Javaid M., Jing C., Jones J.,
RA   Joshi V., Kamau G., Korchina V., Lee S., Lorensuhewa L., Mata R.,
RA   Mathew T., Mims S., Ngo R., Nguyen L., Okwuonu G., Ongeri F., Osuji N.,
RA   Pham C., Puazo M., Qu C., Quiroz J., Raj R., Rio Deiros D., Santibanez J.,
RA   Scheel M., Scherer S., Vee V., Wang M., Xin Y., Richards S., Reid J.G.,
RA   Newsham I., Worley K.C., Muzny D.M., Gibbs R.;
RL   Submitted (NOV-2010) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 73-82, MASS SPECTROMETRY, PYROGLUTAMATE FORMATION AT
RP   GLN-73, AND AMIDATION AT PHE-82.
RC   TISSUE=Brain {ECO:0000269|PubMed:17068263};
RX   PubMed=17068263; DOI=10.1126/science.1124128;
RA   Hummon A.B., Richmond T.A., Verleyen P., Baggerman G., Huybrechts J.,
RA   Ewing M.A., Vierstraete E., Rodriguez-Zas S.L., Schoofs L., Robinson G.E.,
RA   Sweedler J.V.;
RT   "From the genome to the proteome: uncovering peptides in the Apis brain.";
RL   Science 314:647-649(2006).
CC   -!- FUNCTION: Myoinhibiting neuropeptide. {ECO:0000250|UniProtKB:P61849}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250|UniProtKB:P61849}.
CC   -!- MASS SPECTROMETRY: Mass=1257.5; Method=Electrospray;
CC       Evidence={ECO:0000269|PubMed:17068263};
CC   -!- SIMILARITY: Belongs to the myosuppressin family. {ECO:0000305}.
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DR   EMBL; AADG06001837; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; P85527; -.
DR   STRING; 7460.GB44942-PA; -.
DR   PaxDb; P85527; -.
DR   eggNOG; ENOG502SDA3; Eukaryota.
DR   HOGENOM; CLU_177213_0_0_1; -.
DR   InParanoid; P85527; -.
DR   OMA; HIKKVCM; -.
DR   PhylomeDB; P85527; -.
DR   Proteomes; UP000005203; Linkage group 11.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Pyrrolidone carboxylic acid; Reference proteome; Secreted;
KW   Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..70
FT                   /evidence="ECO:0000255, ECO:0000269|PubMed:17068263"
FT                   /id="PRO_0000341449"
FT   PEPTIDE         73..82
FT                   /note="Myosuppressin"
FT                   /evidence="ECO:0000269|PubMed:17068263"
FT                   /id="PRO_0000341450"
FT   MOD_RES         73
FT                   /note="Pyrrolidone carboxylic acid"
FT                   /evidence="ECO:0000269|PubMed:17068263"
FT   MOD_RES         82
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:17068263"
SQ   SEQUENCE   86 AA;  9788 MW;  A80BC13408161AF3 CRC64;
     MAIFCNNVLA ALPTQCNPGF LDDLPPRIRK VCVALSRIYE LGSEMESYIG DKENHITGFH
     ESIPLLDSGV KRQDVDHVFL RFGRRR