ID   NEMS_AGRIP              Reviewed;          96 AA.
AC   C0HKU2;
DT   23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT   23-MAY-2018, sequence version 1.
DT   25-MAY-2022, entry version 6.
DE   RecName: Full=Myosuppressin {ECO:0000303|PubMed:29466015};
DE   Flags: Precursor;
OS   Agrotis ipsilon (Black cutworm moth).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Lepidoptera; Glossata; Ditrysia; Noctuoidea;
OC   Noctuidae; Noctuinae; Noctuini; Agrotis.
OX   NCBI_TaxID=56364;
RN   [1] {ECO:0000305}
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 83-92, TISSUE SPECIFICITY,
RP   MASS SPECTROMETRY, IDENTIFICATION BY MASS SPECTROMETRY, AMIDATION AT
RP   PHE-92, AND PYROGLUTAMATE FORMATION AT GLN-83.
RX   PubMed=29466015; DOI=10.1021/acs.jproteome.7b00779;
RA   Diesner M., Gallot A., Binz H., Gaertner C., Vitecek S., Kahnt J.,
RA   Schachtner J., Jacquin-Joly E., Gadenne C.;
RT   "Mating-induced differential peptidomics of neuropeptides and protein
RT   hormones in Agrotis ipsilon moths.";
RL   J. Proteome Res. 17:1397-1414(2018).
CC   -!- FUNCTION: Myoinhibiting neuropeptide. {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000305}.
CC   -!- TISSUE SPECIFICITY: Expressed in corpora cardiaca (CC), corpora allata
CC       (CA), antennal lobe (AL) and gnathal ganglion (GNG) (at protein level).
CC       In its non-pyroglutamate form, expression in GNG detected in all
CC       animals, in AL, CC and in CA in most animals (at protein level). In its
CC       pyroglutamate form, expression in CC, CA and GNG detected in all
CC       animals, in AL in some animals (at protein level).
CC       {ECO:0000269|PubMed:29466015}.
CC   -!- MASS SPECTROMETRY: Mass=1246.66; Method=MALDI; Note=Non-pyroglutamate
CC       form.; Evidence={ECO:0000269|PubMed:29466015};
CC   -!- MASS SPECTROMETRY: Mass=1229.65; Method=MALDI; Note=Pyroglutamate
CC       form.; Evidence={ECO:0000269|PubMed:29466015};
CC   -!- SIMILARITY: Belongs to the myosuppressin family. {ECO:0000305}.
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DR   AlphaFoldDB; C0HKU2; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0007218; P:neuropeptide signaling pathway; IEA:UniProtKB-KW.
PE   1: Evidence at protein level;
KW   Amidation; Cleavage on pair of basic residues; Direct protein sequencing;
KW   Neuropeptide; Pyrrolidone carboxylic acid; Secreted; Signal.
FT   SIGNAL          1..24
FT                   /evidence="ECO:0000255"
FT   PROPEP          25..80
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444239"
FT   PEPTIDE         83..92
FT                   /note="Myosuppressin"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT                   /id="PRO_0000444240"
FT   PROPEP          96
FT                   /evidence="ECO:0000305"
FT                   /id="PRO_0000444241"
FT   MOD_RES         83
FT                   /note="Pyrrolidone carboxylic acid; partial"
FT                   /evidence="ECO:0000269|PubMed:29466015"
FT   MOD_RES         92
FT                   /note="Phenylalanine amide"
FT                   /evidence="ECO:0000269|PubMed:29466015"
SQ   SEQUENCE   96 AA;  10503 MW;  FC0F68E4F927F48A CRC64;
     MALGNGYYCA VVCVVLACAS VVLCAPAQLC AGAADDDPRA ARFCQALNTF LELYAEAAGE
     QVPEYQALVR DYPQLLDTGM KRQDVVHSFL RFGRRR