ID   NDBP_LYCMC              Reviewed;          87 AA.
AC   D9U2B7;
DT   11-JAN-2011, integrated into UniProtKB/Swiss-Prot.
DT   05-OCT-2010, sequence version 1.
DT   03-AUG-2022, entry version 21.
DE   RecName: Full=Bradykinin-potentiating peptide NDBP12 {ECO:0000303|PubMed:20663230};
DE            Short=BPP-12 {ECO:0000303|PubMed:20663230};
DE   Flags: Precursor;
OS   Lychas mucronatus (Chinese swimming scorpion).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Chelicerata; Arachnida;
OC   Scorpiones; Buthida; Buthoidea; Buthidae; Lychas.
OX   NCBI_TaxID=172552;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Hainan; TISSUE=Venom gland;
RX   PubMed=20663230; DOI=10.1186/1471-2164-11-452;
RA   Zhao R., Ma Y., He Y., Di Z., Wu Y.-L., Cao Z.-J., Li W.-X.;
RT   "Comparative venom gland transcriptome analysis of the scorpion Lychas
RT   mucronatus reveals intraspecific toxic gene diversity and new venomous
RT   components.";
RL   BMC Genomics 11:452-452(2010).
CC   -!- FUNCTION: Inhibits angiotensin-converting enzyme (ACE), but does not
CC       serve as substrate for the enzyme. Potentiates bradykinin (BK) on the
CC       isolated guinea pig ileum as well as the isolated rat uterus for
CC       contraction. Also potentiates in vivo the depressor effect of BK on
CC       arterial blood pressure in the normotensive anesthetized rat.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland. {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the non-disulfide-bridged peptide (NDBP)
CC       superfamily. Long chain multifunctional peptide (group 2) family.
CC       {ECO:0000305}.
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DR   EMBL; EU163895; ABY26704.1; -; mRNA.
DR   AlphaFoldDB; D9U2B7; -.
DR   SMR; D9U2B7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR   GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR   GO; GO:0008217; P:regulation of blood pressure; IEA:UniProtKB-KW.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Hypotensive agent;
KW   Metalloenzyme inhibitor; Metalloprotease inhibitor; Protease inhibitor;
KW   Secreted; Signal; Toxin.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000305"
FT   CHAIN           23..82
FT                   /note="Bradykinin-potentiating peptide NDBP12"
FT                   /id="PRO_0000403873"
FT   REGION          64..87
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   87 AA;  9968 MW;  FD74E475203E85A0 CRC64;
     MNKRVLLVIF FVTLLVADEV NSFSFFRKAK GFLKKIWKSK IARRLREKGM KALKNYANDV
     LNGPAEAPAP AAAAPEEPPV EQRRRRR