NCOA7_MOUSE
ID NCOA7_MOUSE Reviewed; 943 AA.
AC Q6DFV7; Q3TAR1; Q3UNB3; Q66K05; Q6ZQM4; Q8BJ15; Q8BJ39;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 135.
DE RecName: Full=Nuclear receptor coactivator 7;
GN Name=Ncoa7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Ninomiya K., Wagatsuma M., Kanda K., Kondo H., Yokoi T., Kodaira H.,
RA Furuya T., Takahashi M., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Sugiyama T., Irie R.,
RA Otsuki T., Sato H., Ota T., Wakamatsu A., Ishii S., Yamamoto J., Isono Y.,
RA Kawai-Hio Y., Saito K., Nishikawa T., Kimura K., Yamashita H., Matsuo K.,
RA Nakamura Y., Sekine M., Kikuchi H., Murakawa K., Kanehori K.,
RA Takahashi-Fujii A., Oshima A., Sugiyama A., Kawakami B., Suzuki Y.,
RA Sugano S., Nagahari K., Masuho Y., Nagai K., Isogai T.;
RT "NEDO cDNA sequencing project.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5).
RC STRAIN=C57BL/6J; TISSUE=Colon, Lung, Spleen, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 6), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 19-943.
RC STRAIN=C57BL/6J; TISSUE=Head, Kidney, and Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=11971969; DOI=10.1128/mcb.22.10.3358-3372.2002;
RA Shao W., Halachmi S., Brown M.;
RT "ERAP140, a conserved tissue-specific nuclear receptor coactivator.";
RL Mol. Cell. Biol. 22:3358-3372(2002).
RN [5]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-92; SER-211; SER-212;
RP SER-214; SER-498 AND SER-500, AND IDENTIFICATION BY MASS SPECTROMETRY
RP [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Brown adipose tissue, Kidney, Lung, Spleen, and Testis;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Enhances the transcriptional activities of several nuclear
CC receptors. Involved in the coactivation of different nuclear receptors,
CC such as ESR1, THRB, PPARG and RARA (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Interacts with ESR1, ESR2A, ESR2B, THRB, PPARG and RARA in a
CC ligand-inducible manner. Interacts with the heterodimer AHR-ARNT (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=6;
CC Name=1;
CC IsoId=Q6DFV7-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6DFV7-2; Sequence=VSP_019641, VSP_019642;
CC Name=3;
CC IsoId=Q6DFV7-3; Sequence=VSP_019640, VSP_019643;
CC Name=4;
CC IsoId=Q6DFV7-4; Sequence=VSP_019640, VSP_019643, VSP_019648;
CC Name=5;
CC IsoId=Q6DFV7-5; Sequence=VSP_019640, VSP_019643, VSP_019644,
CC VSP_019647;
CC Name=6;
CC IsoId=Q6DFV7-6; Sequence=VSP_019640, VSP_019643, VSP_019645,
CC VSP_019646;
CC -!- TISSUE SPECIFICITY: Highly expressed in brain and kidney. Weakly
CC expressed in mammary gland, lung and testis. In brain, expression is
CC found in neurons of cerebral cortex, thalamus, hypothalamus,
CC hippocampus, cerebellum, striatum and choroid plexus.
CC {ECO:0000269|PubMed:11971969}.
CC -!- SIMILARITY: Belongs to the OXR1 family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC87660.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK128935; BAC87660.1; ALT_FRAME; mRNA.
DR EMBL; AK033503; BAC28325.1; -; mRNA.
DR EMBL; AK042369; BAC31241.1; -; mRNA.
DR EMBL; AK144324; BAE25834.1; -; mRNA.
DR EMBL; AK171679; BAE42607.1; -; mRNA.
DR EMBL; BC049997; AAH49997.1; -; mRNA.
DR EMBL; BC058572; AAH58572.1; -; mRNA.
DR EMBL; BC076623; AAH76623.1; -; mRNA.
DR EMBL; BC080670; AAH80670.1; -; mRNA.
DR CCDS; CCDS23765.1; -. [Q6DFV7-1]
DR CCDS; CCDS48530.1; -. [Q6DFV7-3]
DR RefSeq; NP_001104737.1; NM_001111267.2. [Q6DFV7-3]
DR RefSeq; NP_766083.3; NM_172495.5. [Q6DFV7-1]
DR AlphaFoldDB; Q6DFV7; -.
DR SMR; Q6DFV7; -.
DR BioGRID; 229223; 9.
DR STRING; 10090.ENSMUSP00000066741; -.
DR iPTMnet; Q6DFV7; -.
DR PhosphoSitePlus; Q6DFV7; -.
DR EPD; Q6DFV7; -.
DR jPOST; Q6DFV7; -.
DR MaxQB; Q6DFV7; -.
DR PaxDb; Q6DFV7; -.
DR PeptideAtlas; Q6DFV7; -.
DR PRIDE; Q6DFV7; -.
DR ProteomicsDB; 252653; -. [Q6DFV7-1]
DR ProteomicsDB; 252654; -. [Q6DFV7-2]
DR ProteomicsDB; 252655; -. [Q6DFV7-3]
DR ProteomicsDB; 252656; -. [Q6DFV7-4]
DR ProteomicsDB; 252657; -. [Q6DFV7-5]
DR ProteomicsDB; 252658; -. [Q6DFV7-6]
DR Antibodypedia; 32708; 212 antibodies from 30 providers.
DR DNASU; 211329; -.
DR Ensembl; ENSMUST00000068567; ENSMUSP00000066741; ENSMUSG00000039697. [Q6DFV7-1]
DR Ensembl; ENSMUST00000092610; ENSMUSP00000090273; ENSMUSG00000039697. [Q6DFV7-5]
DR Ensembl; ENSMUST00000213897; ENSMUSP00000148944; ENSMUSG00000039697. [Q6DFV7-6]
DR Ensembl; ENSMUST00000215725; ENSMUSP00000150800; ENSMUSG00000039697. [Q6DFV7-2]
DR Ensembl; ENSMUST00000215740; ENSMUSP00000149335; ENSMUSG00000039697. [Q6DFV7-1]
DR Ensembl; ENSMUST00000216172; ENSMUSP00000150981; ENSMUSG00000039697. [Q6DFV7-3]
DR Ensembl; ENSMUST00000217644; ENSMUSP00000150671; ENSMUSG00000039697. [Q6DFV7-4]
DR GeneID; 211329; -.
DR KEGG; mmu:211329; -.
DR UCSC; uc007etj.2; mouse. [Q6DFV7-5]
DR UCSC; uc007etk.2; mouse. [Q6DFV7-1]
DR UCSC; uc007etm.2; mouse. [Q6DFV7-4]
DR UCSC; uc007eto.2; mouse. [Q6DFV7-2]
DR CTD; 135112; -.
DR MGI; MGI:2444847; Ncoa7.
DR VEuPathDB; HostDB:ENSMUSG00000039697; -.
DR eggNOG; KOG2372; Eukaryota.
DR GeneTree; ENSGT00940000155141; -.
DR HOGENOM; CLU_029204_4_1_1; -.
DR InParanoid; Q6DFV7; -.
DR OMA; SEDNCKF; -.
DR OrthoDB; 767847at2759; -.
DR PhylomeDB; Q6DFV7; -.
DR TreeFam; TF313530; -.
DR BioGRID-ORCS; 211329; 2 hits in 69 CRISPR screens.
DR ChiTaRS; Ncoa7; mouse.
DR PRO; PR:Q6DFV7; -.
DR Proteomes; UP000000589; Chromosome 10.
DR RNAct; Q6DFV7; protein.
DR Bgee; ENSMUSG00000039697; Expressed in uterine cervix and 215 other tissues.
DR ExpressionAtlas; Q6DFV7; baseline and differential.
DR Genevisible; Q6DFV7; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0016922; F:nuclear receptor binding; ISS:UniProtKB.
DR GO; GO:0030374; F:nuclear receptor coactivator activity; ISS:UniProtKB.
DR GO; GO:1900408; P:negative regulation of cellular response to oxidative stress; IDA:MGI.
DR GO; GO:1903204; P:negative regulation of oxidative stress-induced neuron death; IDA:MGI.
DR GO; GO:1902083; P:negative regulation of peptidyl-cysteine S-nitrosylation; IDA:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISS:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006979; P:response to oxidative stress; IBA:GO_Central.
DR CDD; cd00118; LysM; 1.
DR Gene3D; 3.10.350.10; -; 1.
DR InterPro; IPR018392; LysM_dom.
DR InterPro; IPR036779; LysM_dom_sf.
DR InterPro; IPR006571; TLDc_dom.
DR Pfam; PF01476; LysM; 1.
DR Pfam; PF07534; TLD; 1.
DR SMART; SM00257; LysM; 1.
DR SMART; SM00584; TLDc; 1.
DR SUPFAM; SSF54106; SSF54106; 1.
DR PROSITE; PS51782; LYSM; 1.
DR PROSITE; PS51886; TLDC; 1.
PE 1: Evidence at protein level;
KW Acetylation; Activator; Alternative splicing; Coiled coil; Nucleus;
KW Phosphoprotein; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..943
FT /note="Nuclear receptor coactivator 7"
FT /id="PRO_0000245230"
FT DOMAIN 117..160
FT /note="LysM"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01118"
FT DOMAIN 782..943
FT /note="TLDc"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU01234"
FT REGION 1..83
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 169..189
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 334..369
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 486..507
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 543..576
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1..32
FT /evidence="ECO:0000255"
FT COMPBIAS 1..16
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 44..83
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..187
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 334..366
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 486..500
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 1
FT /note="N-acetylmethionine"
FT /evidence="ECO:0000250|UniProtKB:Q8NI08"
FT MOD_RES 92
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 137
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q8NI08"
FT MOD_RES 182
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NI08"
FT MOD_RES 186
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NI08"
FT MOD_RES 211
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 212
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 214
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 442
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NI08"
FT MOD_RES 498
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 500
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT VAR_SEQ 1..722
FT /note="Missing (in isoform 3, isoform 4, isoform 5 and
FT isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_019640"
FT VAR_SEQ 237..271
FT /note="GVVGGVMIVTPNNIMFDPHKSDPLVIENGCEEYGL -> VSATVIAYWSGNL
FT QKLNKKTHCWMGVFYPQLKCMI (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019641"
FT VAR_SEQ 272..943
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019642"
FT VAR_SEQ 723..747
FT /note="FVVVEKEELNMIDNFFSEPTTKSWE -> MRGRGLPLDIQIFYCARPDQEPF
FT VK (in isoform 3, isoform 4, isoform 5 and isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334,
FT ECO:0000303|PubMed:16141072"
FT /id="VSP_019643"
FT VAR_SEQ 875..883
FT /note="VFKWSGENS -> GTIWSVARC (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019644"
FT VAR_SEQ 875..881
FT /note="VFKWSGE -> PISHLGH (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019645"
FT VAR_SEQ 882..943
FT /note="Missing (in isoform 6)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_019646"
FT VAR_SEQ 884..943
FT /note="Missing (in isoform 5)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019647"
FT VAR_SEQ 900..943
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:16141072"
FT /id="VSP_019648"
SQ SEQUENCE 943 AA; 106357 MW; 872D551ACEEE5109 CRC64;
MDTKEEKKEQ KERKQSYFAR LKKKKQAKQN AEIVSAASSK SRSGKDDANS DILEQDKFNV
TAEGDHSTDD KKKRKSNQLK EIRRTELKRY YSVDDNQNKT HDKKEKKMMV QKPQGTMEYT
AGSQDTLNSV ALKFNVTPNK LVELNKLFTH TIVPGQVLFV PDANISSSTI QLSSSTPGAT
VSPSSSDAEY DKLPDADLAR KALKPIERVL SSTSEEDEPG VVKFLKMNCR YFTDGKGVVG
GVMIVTPNNI MFDPHKSDPL VIENGCEEYG LICPMEEVVS IALYSDISHM KIKDALPSDL
PRDLCPLYRP GEWEDLASEK DINPFSKFKS INKEKRQQNG ERTLALDAKS VRSPEESTER
TCTRIEPPDN SELWKLKNLQ SSRGTTSESP SVTQLSMRAA LEPTAKENCL LKGDEDFVDL
EELSSQPESG INKGDATKEC LSYDQKKDGP HTVMSAKKGH VQSAQEVMGP ESDTELKGAL
DLETAEKQDE APEVDKHSGS PENLGESTLN IHEDLDKIKL IEFYLNKNKE GSQLLENVQK
SELSDRKSIE PGGIDITLSS SLPQAGDSPP EDNKEPGTLW VKGGETLPLK LDPSAEETVI
NNKEVLDSLG SSLDKMCHSA QMDNKSEIQL WLLKRIQVPI EDILPSKEEK SKTPPMFLCI
KVGKPMRKSF ASHTATMVQQ YSKRRKQPEY WFAVPRERVD HLYTFFVQWS PDVYGKDAKE
QGFVVVEKEE LNMIDNFFSE PTTKSWEIIT VEEAKRRKST CSYYEEEEEE EEGLPILQPH
SALLENMHIE QLARRLPARV QGYPWRLAYS TLEHGTSLKT LYRKSASLDS PVLLVIKDMD
NQIFGAYATH PFKFSDHYYG TGETFLYTFS PNFKVFKWSG ENSYFINGDI SSLELGGGGG
RFGLWLDADL YHGRSNSCST FNNDILSKKE DFIVQDLEVW TFE
