NCMAP_HUMAN
ID NCMAP_HUMAN Reviewed; 102 AA.
AC Q5T1S8; A0PK04; B2RV34;
DT 12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT 21-DEC-2004, sequence version 1.
DT 03-AUG-2022, entry version 97.
DE RecName: Full=Noncompact myelin-associated protein;
DE AltName: Full=Myelin protein of 11 kDa;
DE Short=MP11;
GN Name=NCMAP; Synonyms=C1orf130;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16710414; DOI=10.1038/nature04727;
RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A.,
RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C.,
RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.,
RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C.,
RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W.,
RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J.,
RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J.,
RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y.,
RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J.,
RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H.,
RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L.,
RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J.,
RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S.,
RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K.,
RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R.,
RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M.,
RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S.,
RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J.,
RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W.,
RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N.,
RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V.,
RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J.,
RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E.,
RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S.,
RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M.,
RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H.,
RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E.,
RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G.,
RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.;
RT "The DNA sequence and biological annotation of human chromosome 1.";
RL Nature 441:315-321(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Plays a role in myelin formation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type I
CC membrane protein {ECO:0000250}. Note=Localized mainly in the Schmidt-
CC Lanterman incisures and paranodes of noncompact peripheral nerve
CC myelin. {ECO:0000250}.
CC -!- PTM: Glycosylated. {ECO:0000250}.
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DR EMBL; AL445686; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC127785; AAI27786.1; -; mRNA.
DR EMBL; BC147014; AAI47015.1; -; mRNA.
DR EMBL; BC147015; AAI47016.1; -; mRNA.
DR CCDS; CCDS30632.1; -.
DR RefSeq; NP_001010980.1; NM_001010980.4.
DR RefSeq; XP_005245929.1; XM_005245872.3.
DR RefSeq; XP_011539765.1; XM_011541463.2.
DR AlphaFoldDB; Q5T1S8; -.
DR SMR; Q5T1S8; -.
DR STRING; 9606.ENSP00000363513; -.
DR BioMuta; NCMAP; -.
DR DMDM; 74744510; -.
DR MassIVE; Q5T1S8; -.
DR PaxDb; Q5T1S8; -.
DR PeptideAtlas; Q5T1S8; -.
DR PRIDE; Q5T1S8; -.
DR Antibodypedia; 2689; 69 antibodies from 12 providers.
DR DNASU; 400746; -.
DR Ensembl; ENST00000374392.3; ENSP00000363513.2; ENSG00000184454.7.
DR GeneID; 400746; -.
DR KEGG; hsa:400746; -.
DR MANE-Select; ENST00000374392.3; ENSP00000363513.2; NM_001010980.5; NP_001010980.1.
DR UCSC; uc001bjk.3; human.
DR CTD; 400746; -.
DR GeneCards; NCMAP; -.
DR HGNC; HGNC:29332; NCMAP.
DR HPA; ENSG00000184454; Tissue enhanced (gallbladder, pancreas, salivary gland).
DR neXtProt; NX_Q5T1S8; -.
DR OpenTargets; ENSG00000184454; -.
DR PharmGKB; PA142672448; -.
DR VEuPathDB; HostDB:ENSG00000184454; -.
DR eggNOG; ENOG502S4WJ; Eukaryota.
DR GeneTree; ENSGT00390000004116; -.
DR HOGENOM; CLU_176667_0_0_1; -.
DR InParanoid; Q5T1S8; -.
DR OMA; PVDVHME; -.
DR OrthoDB; 1609304at2759; -.
DR PhylomeDB; Q5T1S8; -.
DR TreeFam; TF336902; -.
DR PathwayCommons; Q5T1S8; -.
DR BioGRID-ORCS; 400746; 12 hits in 1067 CRISPR screens.
DR ChiTaRS; NCMAP; human.
DR GenomeRNAi; 400746; -.
DR Pharos; Q5T1S8; Tbio.
DR PRO; PR:Q5T1S8; -.
DR Proteomes; UP000005640; Chromosome 1.
DR RNAct; Q5T1S8; protein.
DR Bgee; ENSG00000184454; Expressed in tibial nerve and 80 other tissues.
DR GO; GO:0005887; C:integral component of plasma membrane; ISS:UniProtKB.
DR GO; GO:0033270; C:paranode region of axon; ISS:UniProtKB.
DR GO; GO:0043220; C:Schmidt-Lanterman incisure; ISS:UniProtKB.
DR GO; GO:0019911; F:structural constituent of myelin sheath; ISS:UniProtKB.
DR GO; GO:0032290; P:peripheral nervous system myelin formation; ISS:UniProtKB.
DR GO; GO:0031643; P:positive regulation of myelination; ISS:UniProtKB.
DR InterPro; IPR038940; NCMAP.
DR PANTHER; PTHR35974; PTHR35974; 1.
PE 3: Inferred from homology;
KW Cell membrane; Glycoprotein; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..102
FT /note="Noncompact myelin-associated protein"
FT /id="PRO_0000265078"
FT TOPO_DOM 1..30
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 31..51
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 52..102
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 60..102
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 75..102
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 102 AA; 11082 MW; 2600885D1B148BE9 CRC64;
MTTATPLGDT TFFSLNMTTR GEDFLYKSSG AIVAAVVVVV IIIFTVVLIL LKMYNRKMRT
RRELEPKGPK PTAPSAVGPN SNGSQHPATV TFSPVDVQVE TR
