NCAP_MEASW
ID NCAP_MEASW Reviewed; 525 AA.
AC B8PZP3;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 23-FEB-2022, entry version 39.
DE RecName: Full=Nucleoprotein;
DE AltName: Full=Nucleocapsid protein;
DE Short=NP;
DE Short=Protein N;
GN Name=N; Synonyms=NP;
OS Measles virus (strain Edmonston-Schwarz vaccine) (MeV) (Subacute sclerose
OS panencephalitis virus).
OC Viruses; Riboviria; Orthornavirae; Negarnaviricota; Haploviricotina;
OC Monjiviricetes; Mononegavirales; Paramyxoviridae; Orthoparamyxovirinae;
OC Morbillivirus.
OX NCBI_TaxID=132487;
OH NCBI_TaxID=9606; Homo sapiens (Human).
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RX PubMed=8191786; DOI=10.1016/0168-1702(94)90025-6;
RA Rota J.S., Wang Z.D., Rota P.A., Bellini W.J.;
RT "Comparison of sequences of the H, F, and N coding genes of measles virus
RT vaccine strains.";
RL Virus Res. 31:317-330(1994).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Rouvax-Schwarz;
RA Herschke F., Azocar O., Druelle J., Waku-Kouomou D., Duhen T., Plumet S.,
RA Delprat C., Wild F., Rabourdin-Combe C., Gerlier D., Valentin H.;
RT "Heterogeneity of the interferon a/b response to measles infection governed
RT by genome sequence, host cell type, dendritic cell maturation state and
RT donors.";
RL Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [GENOMIC RNA].
RC STRAIN=Attenuated Edmonston Enders (Morten), and Edmonston-Schwarz vaccine;
RX PubMed=19428841; DOI=10.1016/j.vaccine.2009.01.112;
RA Tillieux S.L., Halsey W.S., Sathe G.M., Vassilev V.;
RT "Comparative analysis of the complete nucleotide sequences of measles,
RT mumps, and rubella strain genomes contained in Priorix-Tetra and ProQuad
RT live attenuated combined vaccines.";
RL Vaccine 27:2265-2273(2009).
CC -!- FUNCTION: Encapsidates the genome in a ratio of 1 N per 6
CC ribonucleotides, protecting it from nucleases. The nucleocapsid (NC)
CC has a helical structure with either 12.35 or 11.64 N per turn,
CC approximately 20 nm in diameter, with a hollow central cavity
CC approximately 5 nm in diameter. The encapsidated genomic RNA is termed
CC the NC and serves as template for transcription and replication. During
CC replication, encapsidation by N is coupled to RNA synthesis and all
CC replicative products are resistant to nucleases. N is released in the
CC blood following lysis of measles infected cells, it interacts then with
CC human FCGR2B on immune cells, inducing apoptosis and blocking
CC inflammatory immune response. Ntail binds to a protein on human thymic
CC epithelial cells, termed Nucleoprotein Receptor (NR), inducing growth
CC arrest (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homomultimerizes to form the nucleocapsid. Binds to viral
CC genomic RNA. In nucleocapsid, binds the P protein and thereby positions
CC the polymerase on the template. Interacts with human FCGR2B protein (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Virion {ECO:0000305}. Host cytoplasm
CC {ECO:0000250}.
CC -!- DOMAIN: Ncore is globular and carries regions required for N self-
CC assembly and RNA-binding. Ntail is an intrinsically disordered
CC monomeric domain (By similarity). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the paramyxoviruses nucleocapsid family.
CC {ECO:0000305}.
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DR EMBL; U03668; AAA56658.1; -; Genomic_RNA.
DR EMBL; EU332918; ACC86073.1; -; mRNA.
DR EMBL; FJ211583; ACN50008.1; -; Viral_cRNA.
DR EMBL; FJ211589; ACN50047.1; -; Viral_cRNA.
DR EMBL; FJ211590; ACN50055.1; -; Viral_cRNA.
DR BMRB; B8PZP3; -.
DR SMR; B8PZP3; -.
DR IntAct; B8PZP3; 8.
DR Proteomes; UP000135893; Genome.
DR Proteomes; UP000152604; Genome.
DR Proteomes; UP000180902; Genome.
DR GO; GO:0019029; C:helical viral capsid; IEA:UniProtKB-KW.
DR GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019013; C:viral nucleocapsid; IEA:UniProtKB-KW.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR InterPro; IPR002021; Paramyx_ncap.
DR Pfam; PF00973; Paramyxo_ncap; 1.
PE 2: Evidence at transcript level;
KW Capsid protein; Helical capsid protein; Host cytoplasm;
KW Host-virus interaction; Ribonucleoprotein; RNA-binding;
KW Viral nucleoprotein; Virion.
FT CHAIN 1..525
FT /note="Nucleoprotein"
FT /id="PRO_0000387981"
FT REGION 1..400
FT /note="Ncore"
FT /evidence="ECO:0000250"
FT REGION 1..375
FT /note="Homomultimerization"
FT /evidence="ECO:0000250"
FT REGION 401..525
FT /note="Ntail"
FT /evidence="ECO:0000250"
FT REGION 418..525
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..505
FT /note="P protein-binding"
FT /evidence="ECO:0000250"
FT COMPBIAS 428..456
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 525 AA; 58073 MW; 10D0D3A538761717 CRC64;
MATLLRSLAL FKRNKDKPPI TSGSGGAIRG IKHIIIVPIP GDSSITTRSR LLDRLVRLIG
NPDVSGPKLT GALIGILSLF VESPGQLIQR ITDDPDVSIR LLEVVQSDQS QSGLTFASRG
TNMEDEADQY FSHDDPISSD QSRFGWFGNK EISDIEVQDP EGFNMILGTI LAQIWVLLAK
AVTAPDTAAD SELRRWIKYT QQRRVVGEFR LERKWLDVVR NRIAEDLSLR RFMVALILDI
KRTPGNKPRI AEMICDIDTY IVEAGLASFI LTIKFGIETM YPALGLHEFA GELSTLESLM
NLYQQMGETA PYMVILENSI QNKFSAGSYP LLWSYAMGVG VELENSMGGL NFGRSYFDPA
YFRLGQEMVR RSAGKVSSTL ASELGITAED ARLVSEIAMH TTEDKISRAV GPRQAQVSFL
HGDQSENELP RLGGKEDRRV KQSRGEARES YRETGPSRAS DARAAHLPTG TPLDIDTATE
SSQDPQDSRR SADALLRLQA MAGISEEQGS DTDTPIVYND RNLLD
