ID   A11_VAR67               Reviewed;         319 AA.
AC   P0DOQ7; P33836;
DT   16-OCT-2019, integrated into UniProtKB/Swiss-Prot.
DT   16-OCT-2019, sequence version 1.
DT   23-FEB-2022, entry version 6.
DE   RecName: Full=Protein A11;
GN   ORFNames=A11R;
OS   Variola virus (isolate Human/India/Ind3/1967) (VARV) (Smallpox virus).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus.
OX   NCBI_TaxID=587200;
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=8384129; DOI=10.1016/0014-5793(93)80041-r;
RA   Shchelkunov S.N., Blinov V.M., Sandakhchiev L.S.;
RT   "Genes of variola and vaccinia viruses necessary to overcome the host
RT   protective mechanisms.";
RL   FEBS Lett. 319:80-83(1993).
CC   -!- FUNCTION: Required for viral crescent formation early during virus
CC       morphogenesis. {ECO:0000250}.
CC   -!- SUBUNIT: Homomultimer. Interacts with A32. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm {ECO:0000250}. Note=Localizes to
CC       the cytoplasmic viral factory. Not incorporated into virus particles.
CC       Does not seem to be a transmembrane protein (By similarity).
CC       {ECO:0000250}.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC   -!- PTM: Phosphorylated by a F10-independent mechanism. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the poxviridae A11 family. {ECO:0000305}.
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DR   EMBL; X69198; CAA49056.1; -; Genomic_DNA.
DR   PIR; C36849; C36849.
DR   RefSeq; NP_042159.1; NC_001611.1.
DR   GeneID; 1486486; -.
DR   KEGG; vg:1486486; -.
DR   Proteomes; UP000002060; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007755; Poxvirus_A11.
DR   Pfam; PF05061; Pox_A11; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Host cytoplasm; Late protein; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..319
FT                   /note="Protein A11"
FT                   /id="PRO_0000099233"
FT   COILED          146..173
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   319 AA;  36234 MW;  E36F5BC0498C00D1 CRC64;
     MTTVPVTDIQ NDLITEFSED NYPSNKNYEI TLRQMSILTH VNNVVDREHN AAVVSSPEEI
     SSQLNEDLFP DDDSPATIIE RVQQPHTTII DDTPPPTFRR ELLISEQRQQ REKRFNITVS
     KNAEAIMESR SMITSMPTQT PSLGVVYDKD KRIQMLEDEV VNLRNQQSNT KSSNNLDNFT
     RILFGKTPYK STEVNKRIAI VNYANLNGSP LSVEDLDVCS EDEIDRIYKT IKQYHESRKR
     KIIVTNVIII VINIIEQALL KLGFDEIKGL STDITSEIID VEIGDDCDAV ASKLGIGNSP
     VLNIVLFILK IFVKRIKII