ID   A11_VACCW               Reviewed;         318 AA.
AC   Q80HV8;
DT   07-DEC-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   02-JUN-2021, entry version 36.
DE   RecName: Full=Protein A11;
GN   OrderedLocusNames=VACWR130; ORFNames=A11R;
OS   Vaccinia virus (strain Western Reserve) (VACV) (Vaccinia virus (strain
OS   WR)).
OC   Viruses; Varidnaviria; Bamfordvirae; Nucleocytoviricota; Pokkesviricetes;
OC   Chitovirales; Poxviridae; Chordopoxvirinae; Orthopoxvirus; Vaccinia virus.
OX   NCBI_TaxID=10254;
OH   NCBI_TaxID=9913; Bos taurus (Bovine).
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Esposito J.J., Frace A.M., Sammons S.A., Olsen-Rasmussen M., Osborne J.,
RA   Wohlhueter R.;
RT   "Sequencing of the coding region of Vaccinia-WR to an average 9-fold
RT   redundancy and an error rate of 0.16/10kb.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   FUNCTION, INDUCTION, PHOSPHORYLATION, INTERACTION WITH A32, AND SUBUNIT.
RX   PubMed=15890898; DOI=10.1128/jvi.79.11.6598-6609.2005;
RA   Resch W., Weisberg A.S., Moss B.;
RT   "Vaccinia virus nonstructural protein encoded by the A11R gene is required
RT   for formation of the virion membrane.";
RL   J. Virol. 79:6598-6609(2005).
CC   -!- FUNCTION: Required for viral crescent formation early during virus
CC       morphogenesis. {ECO:0000269|PubMed:15890898}.
CC   -!- SUBUNIT: Homomultimer (Probable). Interacts with A32.
CC       {ECO:0000269|PubMed:15890898, ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Host cytoplasm. Note=Localizes to the cytoplasmic
CC       viral factory. Not incorporated into virus particles. Does not seem to
CC       be a transmembrane protein.
CC   -!- INDUCTION: Expressed in the late phase of the viral replicative cycle.
CC       {ECO:0000269|PubMed:15890898}.
CC   -!- PTM: Phosphorylated by a F10-independent mechanism.
CC       {ECO:0000269|PubMed:15890898}.
CC   -!- SIMILARITY: Belongs to the poxviridae A11 family. {ECO:0000305}.
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DR   EMBL; AY243312; AAO89409.1; -; Genomic_DNA.
DR   RefSeq; YP_233012.1; NC_006998.1.
DR   SMR; Q80HV8; -.
DR   DNASU; 3707528; -.
DR   GeneID; 3707528; -.
DR   KEGG; vg:3707528; -.
DR   Proteomes; UP000000344; Genome.
DR   GO; GO:0030430; C:host cell cytoplasm; IEA:UniProtKB-SubCell.
DR   InterPro; IPR007755; Poxvirus_A11.
DR   Pfam; PF05061; Pox_A11; 1.
PE   1: Evidence at protein level;
KW   Coiled coil; Host cytoplasm; Late protein; Phosphoprotein;
KW   Reference proteome.
FT   CHAIN           1..318
FT                   /note="Protein A11"
FT                   /id="PRO_0000099232"
FT   COILED          145..172
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   318 AA;  36093 MW;  3FFF1B23A4F96867 CRC64;
     MTTVPVTDIQ NDLITEFSED NYPSNKNYEI TLRQMSILTH VNNVVDREHN AAVVSSPEEI
     SSQLNEDLFP DDDSPATIIE RVQPHTTIID DTPPPTFRRE LLISEQRQQR EKRFNITVSK
     NAEAIMESRS MITSMPTQTP SLGVVYDKDK RIQMLEDEVV NLRNQRSNTK SSDNLDNFTK
     ILFGKTPYKS TEVNKRIAIV NYANLNGSPL SVEDLDVCSE DEIDRIYKTI KQYHESRKQK
     IIVTNVIIIV INIIEQALLK LGFEEIKGLS TDITSEIIDV EIGDDCDAVA SKLGIGNSPV
     LNIVLFILKI FVKRIKII