ID   A1131_ARTBC             Reviewed;         499 AA.
AC   D4AY62;
DT   14-OCT-2015, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 1.
DT   03-AUG-2022, entry version 49.
DE   RecName: Full=Cytochrome P450 ARB_01131 {ECO:0000305};
DE            EC=1.14.14.- {ECO:0000250|UniProtKB:P16141};
DE   Flags: Precursor;
GN   ORFNames=ARB_01131;
OS   Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371) (Trichophyton
OS   mentagrophytes).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Onygenales; Arthrodermataceae; Trichophyton.
OX   NCBI_TaxID=663331;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC MYA-4681 / CBS 112371;
RX   PubMed=21247460; DOI=10.1186/gb-2011-12-1-r7;
RA   Burmester A., Shelest E., Gloeckner G., Heddergott C., Schindler S.,
RA   Staib P., Heidel A., Felder M., Petzold A., Szafranski K., Feuermann M.,
RA   Pedruzzi I., Priebe S., Groth M., Winkler R., Li W., Kniemeyer O.,
RA   Schroeckh V., Hertweck C., Hube B., White T.C., Platzer M., Guthke R.,
RA   Heitman J., Woestemeyer J., Zipfel P.F., Monod M., Brakhage A.A.;
RT   "Comparative and functional genomics provide insights into the
RT   pathogenicity of dermatophytic fungi.";
RL   Genome Biol. 12:R7.1-R7.16(2011).
CC   -!- FUNCTION: Together with an NADPH cytochrome P450 the enzyme system
CC       catalyzes the terminal hydroxylation as the first step in the
CC       assimilation of alkanes and fatty acids.
CC       {ECO:0000250|UniProtKB:P16141}.
CC   -!- COFACTOR:
CC       Name=heme; Xref=ChEBI:CHEBI:30413;
CC         Evidence={ECO:0000250|UniProtKB:P04798};
CC   -!- SIMILARITY: Belongs to the cytochrome P450 family. {ECO:0000305}.
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DR   EMBL; ABSU01000018; EFE31878.1; -; Genomic_DNA.
DR   RefSeq; XP_003012518.1; XM_003012472.1.
DR   AlphaFoldDB; D4AY62; -.
DR   SMR; D4AY62; -.
DR   STRING; 63400.XP_003012518.1; -.
DR   EnsemblFungi; EFE31878; EFE31878; ARB_01131.
DR   GeneID; 9526589; -.
DR   KEGG; abe:ARB_01131; -.
DR   eggNOG; KOG0157; Eukaryota.
DR   HOGENOM; CLU_001570_27_0_1; -.
DR   OMA; VNNCVLD; -.
DR   Proteomes; UP000008866; Unassembled WGS sequence.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0005506; F:iron ion binding; IEA:InterPro.
DR   GO; GO:0004497; F:monooxygenase activity; IEA:UniProtKB-KW.
DR   GO; GO:0016705; F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; IEA:InterPro.
DR   Gene3D; 1.10.630.10; -; 1.
DR   InterPro; IPR001128; Cyt_P450.
DR   InterPro; IPR017972; Cyt_P450_CS.
DR   InterPro; IPR002401; Cyt_P450_E_grp-I.
DR   InterPro; IPR036396; Cyt_P450_sf.
DR   Pfam; PF00067; p450; 1.
DR   PRINTS; PR00463; EP450I.
DR   PRINTS; PR00385; P450.
DR   SUPFAM; SSF48264; SSF48264; 1.
DR   PROSITE; PS00086; CYTOCHROME_P450; 1.
PE   3: Inferred from homology;
KW   Glycoprotein; Heme; Iron; Metal-binding; Monooxygenase; Oxidoreductase;
KW   Reference proteome; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000255"
FT   CHAIN           22..499
FT                   /note="Cytochrome P450 ARB_01131"
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000434501"
FT   BINDING         437
FT                   /ligand="heme"
FT                   /ligand_id="ChEBI:CHEBI:30413"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="axial binding residue"
FT                   /evidence="ECO:0000250|UniProtKB:P04798"
FT   CARBOHYD        23
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ   SEQUENCE   499 AA;  56092 MW;  64D7D61C150E87FE CRC64;
     MLSLIVACLV LPLICYKLVR SYNQSREDEQ FAASKGCQPP RKWSAKWPLG LDMLVKAVRY
     EKRQQILQLF LEEVAASGST FEQNLLFARG IDTVEPRNIE AILSTQFTGS GIFTQDGPQW
     KHSRELLRPQ FMTNRFRNFE QIRHAVNNLI SSVPDSGVVD LQPLFFRLTF ETTLFLLFGH
     YLPSLKSEGI TGHESQFANA FNLGQDYLAQ RGRLGDLYWL LGGREFKDAC KVCHDFIDNA
     VQKALKHSSR EKKVSDEEKE TYVFIDALVQ ETREPSVLRD QCLNILLAGR DTTACCLTWT
     LRLLVQHPDV LSKLRDEVRD TIGMGPDAPD PTISQVKKLS YLSLVIKEVL RLYPSVPVNS
     RAAVKTTTLP TGGGPDGSAP LLVRRGEAVG YCVYAMHRRK DIYGPDADCF RPERWENDAL
     KDVGYGYLPF NGGPRICLGQ EFALLEVGYT VVRLLQTFET IEEAETKVPG APLGEEKQTL
     TLVVSSGEGC WVSMKKGTK