ID   MTO1_PONAB              Reviewed;         692 AA.
AC   Q5RB71;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 75.
DE   RecName: Full=Protein MTO1 homolog, mitochondrial;
DE   Flags: Precursor;
GN   Name=MTO1;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Heart;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in the 5-carboxymethylaminomethyl modification
CC       (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs.
CC       {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692; Evidence={ECO:0000250};
CC   -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the MnmG family. {ECO:0000305}.
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DR   EMBL; CR858783; CAH90989.1; -; mRNA.
DR   RefSeq; NP_001128989.1; NM_001135517.1.
DR   AlphaFoldDB; Q5RB71; -.
DR   SMR; Q5RB71; -.
DR   STRING; 9601.ENSPPYP00000018776; -.
DR   GeneID; 100190829; -.
DR   KEGG; pon:100190829; -.
DR   CTD; 25821; -.
DR   eggNOG; KOG2311; Eukaryota.
DR   InParanoid; Q5RB71; -.
DR   Proteomes; UP000001595; Unplaced.
DR   GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR   GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR   GO; GO:0002098; P:tRNA wobble uridine modification; IEA:InterPro.
DR   Gene3D; 1.10.150.570; -; 1.
DR   Gene3D; 3.50.50.60; -; 2.
DR   HAMAP; MF_00129; MnmG_GidA; 1.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR004416; MnmG.
DR   InterPro; IPR002218; MnmG-rel.
DR   InterPro; IPR020595; MnmG-rel_CS.
DR   InterPro; IPR026904; MnmG_C.
DR   InterPro; IPR044920; MnmG_C_subdom.
DR   InterPro; IPR040131; MnmG_N.
DR   PANTHER; PTHR11806; PTHR11806; 1.
DR   PANTHER; PTHR11806:SF0; PTHR11806:SF0; 1.
DR   Pfam; PF01134; GIDA; 1.
DR   Pfam; PF13932; GIDA_C; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR00136; gidA; 1.
DR   PROSITE; PS01280; GIDA_1; 1.
DR   PROSITE; PS01281; GIDA_2; 1.
PE   2: Evidence at transcript level;
KW   FAD; Flavoprotein; Methylation; Mitochondrion; Reference proteome;
KW   Transit peptide; tRNA processing.
FT   TRANSIT         1..25
FT                   /note="Mitochondrion"
FT                   /evidence="ECO:0000255"
FT   CHAIN           26..692
FT                   /note="Protein MTO1 homolog, mitochondrial"
FT                   /id="PRO_0000042691"
FT   BINDING         43..48
FT                   /ligand="FAD"
FT                   /ligand_id="ChEBI:CHEBI:57692"
FT                   /evidence="ECO:0000250"
FT   MOD_RES         508
FT                   /note="N6-methyllysine"
FT                   /evidence="ECO:0000250|UniProtKB:Q9Y2Z2"
SQ   SEQUENCE   692 AA;  77244 MW;  35595CC6B2FA2D6B CRC64;
     MFYFRGCGRW VAASFTKLQF PLARLSSDST APRTPHFDVI VIGGGHAGTE AATAAARCGS
     RTLLLTHRVD TIGQMSCNPS FGGIGKGHLM REVDALDGLC SRICDQSGVH YKVLNRRKGP
     AVWGLRAQID RKLYKQNMQK EILNTPLLTV QEGAVEDLIL TEPEPEHTGK CRVSGVVLVD
     GSTVYAESVI LTTGTFLRGI IVIGLETHPA GRLGDQPSIG LAQTLEKLGF VVGRLKTGTP
     PRIAKESINF SILNKHTPDN PSIPFSFTNE TVWIKPEDQL PCYLTHTNPR VDEIVLKNLH
     LNSHVKETTR GPRYCPSIES KVLRFPNRLH QVWLEPEGMD SDLIYPQGLS MTLPAELQEK
     MITCIRGLEK AKVIQPGYGV QYDYLDPRQI TPSLETHLVQ RLFFAGQING TTGYEEAAAQ
     GVIAGINASL RVSRKPPFVV SRTEGYIGVL IDDLTTLGTS EPYRMFTSRV EFRLSLRPDN
     ADSRLTLRGY KDAGCVSQQR YERACWMKSS LEEGISVLKS IEFSSSKWKK LIPEASISTS
     RSLPVRALDV LKYEEVDMDS LAKAVPEPLK KYTKCRELAE RLKIEATYES VLFHQLQEIK
     GVQQDEALQL PKDLDYLTIR DVSLSHEVRE KLHFSRPQTI GAASRIPGVT PAAIINLLRF
     VKTTQRRQAA MNESSKTDQY LCDADRLRER EL